Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: A two‐sample Mendelian randomization analysis of European and East Asian populations
Abstract Background Both inflammatory bowel disease (IBD) and hepato‐pancreato‐biliary cancers (HPBC) have been established to cause a huge socioeconomic burden. Epidemiological studies have revealed a close association between IBD and HPBC. Methods Herein, we utilized inverse‐variance weighting to...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6057 |
| _version_ | 1797775575166746624 |
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| author | Jinsheng Huang Xujia Li Jicheng Hong Lingli Huang Qi Jiang Shunqi Guo Yuming Rong Guifang Guo |
| author_facet | Jinsheng Huang Xujia Li Jicheng Hong Lingli Huang Qi Jiang Shunqi Guo Yuming Rong Guifang Guo |
| author_sort | Jinsheng Huang |
| collection | DOAJ |
| description | Abstract Background Both inflammatory bowel disease (IBD) and hepato‐pancreato‐biliary cancers (HPBC) have been established to cause a huge socioeconomic burden. Epidemiological studies have revealed a close association between IBD and HPBC. Methods Herein, we utilized inverse‐variance weighting to conduct a two‐sample Mendelian randomization analysis. We sought to investigate the link between various subtypes of IBD and HPBC. To ensure the accuracy and consistency of our findings, we conducted heterogeneity tests, gene pleiotropy tests, and sensitivity analyses. Results Compared to the general population, IBD patients in Europe exhibited a 1.22‐fold increased incidence of pancreatic cancer (PC) with a 95% confidence interval (CI) of 1.0022–1.4888 (p = 0.0475). We also found a 1.14‐fold increased incidence of PC in Crohn's disease (CD) patients with (95% CI: 1.0017–1.3073, p = 0.0472). In the East Asian population, the incidence of hepatocellular carcinoma (HCC) was 1.28‐fold higher (95% CI = 1.0709–1.5244, p = 0.0065) in IBD patients than in the general population. Additionally, ulcerative colitis (UC) patients displayed 1.12‐fold (95% CI: 1.1466–1.3334, p < 0.0001) and 1.31‐fold (95% CI: 1.0983–1.5641, p = 0.0027) increased incidences of HCC and cholangiocarcinoma (CCA), respectively. Finally, the incidence of PC was 1.19‐fold higher in CD patients than in the general population (95% CI = 1.0741–1.3132, p = 0.0008). Conclusion Our study validated that IBD is a risk factor for HPBC. This causal relationship exhibited significant heterogeneity in different European and East Asian populations. |
| first_indexed | 2024-03-12T22:37:37Z |
| format | Article |
| id | doaj.art-af4a257f8d63455e84259ee98edb6305 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-12T22:37:37Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-af4a257f8d63455e84259ee98edb63052023-07-21T11:20:58ZengWileyCancer Medicine2045-76342023-06-011212135991360910.1002/cam4.6057Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: A two‐sample Mendelian randomization analysis of European and East Asian populationsJinsheng Huang0Xujia Li1Jicheng Hong2Lingli Huang3Qi Jiang4Shunqi Guo5Yuming Rong6Guifang Guo7VIP Department Sun Yat‐sen University Cancer Center Guangzhou ChinaVIP Department Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Emergency Shantou Central Hospital Shantou ChinaVIP Department Sun Yat‐sen University Cancer Center Guangzhou ChinaVIP Department Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Emergency Shantou Central Hospital Shantou ChinaVIP Department Sun Yat‐sen University Cancer Center Guangzhou ChinaVIP Department Sun Yat‐sen University Cancer Center Guangzhou ChinaAbstract Background Both inflammatory bowel disease (IBD) and hepato‐pancreato‐biliary cancers (HPBC) have been established to cause a huge socioeconomic burden. Epidemiological studies have revealed a close association between IBD and HPBC. Methods Herein, we utilized inverse‐variance weighting to conduct a two‐sample Mendelian randomization analysis. We sought to investigate the link between various subtypes of IBD and HPBC. To ensure the accuracy and consistency of our findings, we conducted heterogeneity tests, gene pleiotropy tests, and sensitivity analyses. Results Compared to the general population, IBD patients in Europe exhibited a 1.22‐fold increased incidence of pancreatic cancer (PC) with a 95% confidence interval (CI) of 1.0022–1.4888 (p = 0.0475). We also found a 1.14‐fold increased incidence of PC in Crohn's disease (CD) patients with (95% CI: 1.0017–1.3073, p = 0.0472). In the East Asian population, the incidence of hepatocellular carcinoma (HCC) was 1.28‐fold higher (95% CI = 1.0709–1.5244, p = 0.0065) in IBD patients than in the general population. Additionally, ulcerative colitis (UC) patients displayed 1.12‐fold (95% CI: 1.1466–1.3334, p < 0.0001) and 1.31‐fold (95% CI: 1.0983–1.5641, p = 0.0027) increased incidences of HCC and cholangiocarcinoma (CCA), respectively. Finally, the incidence of PC was 1.19‐fold higher in CD patients than in the general population (95% CI = 1.0741–1.3132, p = 0.0008). Conclusion Our study validated that IBD is a risk factor for HPBC. This causal relationship exhibited significant heterogeneity in different European and East Asian populations.https://doi.org/10.1002/cam4.6057Crohn's diseasehepatobiliary pancreatic cancerinflammatory bowel diseaseMendelian randomizationulcerative colitis |
| spellingShingle | Jinsheng Huang Xujia Li Jicheng Hong Lingli Huang Qi Jiang Shunqi Guo Yuming Rong Guifang Guo Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: A two‐sample Mendelian randomization analysis of European and East Asian populations Cancer Medicine Crohn's disease hepatobiliary pancreatic cancer inflammatory bowel disease Mendelian randomization ulcerative colitis |
| title | Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: A two‐sample Mendelian randomization analysis of European and East Asian populations |
| title_full | Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: A two‐sample Mendelian randomization analysis of European and East Asian populations |
| title_fullStr | Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: A two‐sample Mendelian randomization analysis of European and East Asian populations |
| title_full_unstemmed | Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: A two‐sample Mendelian randomization analysis of European and East Asian populations |
| title_short | Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: A two‐sample Mendelian randomization analysis of European and East Asian populations |
| title_sort | inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer a two sample mendelian randomization analysis of european and east asian populations |
| topic | Crohn's disease hepatobiliary pancreatic cancer inflammatory bowel disease Mendelian randomization ulcerative colitis |
| url | https://doi.org/10.1002/cam4.6057 |
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