Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease

Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease

The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is a common genetic cause of Parkinson's disease (PD). Although patients with sporadic PD and individuals with LRRK2-linked PD display the classical PD phenotype, it is not known whether or not the same biological pathways are deregulated...

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Bibliographic Details
Main Authors: Eugénie Mutez, Aurore Nkiliza, Karim Belarbi, Amélie de Broucker, Christel Vanbesien-Mailliot, Séverine Bleuse, Aurélie Duflot, Thomas Comptdaer, Pierre Semaille, Renaud Blervaque, David Hot, Frederic Leprêtre, Martin Figeac, Alain Destée, Marie-Christine Chartier-Harlin
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Transcriptome
Peripheral blood mononuclear cell
PBMC
LRRK2 mutation
Immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113003197

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