Perioperative Complications and Safety Evaluation of Robot-Assisted Radical Hysterectomy of Cervical Cancer After Neoadjuvant Chemotherapy
Wei-Fu Chang,1– 3 Ai-Jing Luo,1,3,4 Yi-Feng Yuan,5 Yang Chen,5 Zi-Rui Xin,3,5 Shuai-Shuai Xu1 1Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, People’s Republic of China; 2The Third Xiangya Hospital of Central South University, Changsha 410013,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-06-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/perioperative-complications-and-safety-evaluation-of-robot-assisted-ra-peer-reviewed-article-CMAR |
| _version_ | 1819207384441028608 |
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| author | Chang WF Luo AJ Yuan YF Chen Y Xin ZR Xu SS |
| author_facet | Chang WF Luo AJ Yuan YF Chen Y Xin ZR Xu SS |
| author_sort | Chang WF |
| collection | DOAJ |
| description | Wei-Fu Chang,1– 3 Ai-Jing Luo,1,3,4 Yi-Feng Yuan,5 Yang Chen,5 Zi-Rui Xin,3,5 Shuai-Shuai Xu1 1Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, People’s Republic of China; 2The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan, People’s Republic of China; 3Key Laboratory of Medical Information Research, Central South University, Changsha 410013, Hunan, People’s Republic of China; 4The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, People’s Republic of China; 5School of Life Sciences, Central South University, Changsha 410013, Hunan, People’s Republic of ChinaCorrespondence: Ai-Jing LuoThe Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Furong District, Changsha 410011, Hunan, People’s Republic of ChinaEmail 574224075@qq.comPurpose: To evaluate the perioperative complications of patients with cervical cancer who are treated with robot-assisted radical hysterectomy (RRH) and to further evaluate the safety of patients undergoing NACT.Methods: A total of 805 consecutive cervical cancer patients undergoing RRH were involved in this report. Their clinical characteristics were retrieved from hospital medical records. Perioperative complications were subdivided into intraoperative and postoperative complications, which were graded according to the Clavien–Dindo classification (CDC), and the complications of grade III and above were defined as severe complications. Furthermore, the two-level logistic regression model was used to estimate the risk factors of perioperative and severe complications and to further confirm the relationship between NACT and perioperative and severe complications.Results: The perioperative complication rate and severe complications were 45.09% and 7.83%, respectively. Poorly differentiated tumor and NACT were identified as independent risk factors for perioperative complications by multifactor analysis. Furthermore, we concentrated on the relations between NACT and complications. The risk of perioperative complications of the group with NACT (OR = 11.08, 95% CI: 5.70– 21.54) was significantly higher than the group without NACT, especially in postoperative complications (OR=17.65, 95% CI: 8.63– 36.08), even after adjusting confounding factors. However, there was no statistically significant difference in terms of severe complications (OR=1.68, 95% CI: 0.64– 4.41) and intraoperative complications (OR=0.51, 95% CI: 0.18– 1.41). Moreover, as the times of NACT increase, the impact on perioperative complications is more pronounced. A similar trend was observed in postoperative complications, while this statistical difference was still not observed in intraoperative and severe complications.Conclusion: This result demonstrates the feasibility and safety of RRH of cervical carcinoma after NACT in generally, since it only causes mild complications, not severe complications.Keywords: cervical carcinoma, robot-assisted radical hysterectomy, neoadjuvant chemotherapy, Clavien–Dindo classification, perioperative complications |
| first_indexed | 2024-12-23T05:22:38Z |
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| id | doaj.art-af4b6d476278483890946be881253827 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-23T05:22:38Z |
| publishDate | 2020-06-01 |
| publisher | Dove Medical Press |
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| series | Cancer Management and Research |
| spelling | doaj.art-af4b6d476278483890946be8812538272022-12-21T17:58:39ZengDove Medical PressCancer Management and Research1179-13222020-06-01Volume 124483449254478Perioperative Complications and Safety Evaluation of Robot-Assisted Radical Hysterectomy of Cervical Cancer After Neoadjuvant ChemotherapyChang WFLuo AJYuan YFChen YXin ZRXu SSWei-Fu Chang,1– 3 Ai-Jing Luo,1,3,4 Yi-Feng Yuan,5 Yang Chen,5 Zi-Rui Xin,3,5 Shuai-Shuai Xu1 1Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, People’s Republic of China; 2The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan, People’s Republic of China; 3Key Laboratory of Medical Information Research, Central South University, Changsha 410013, Hunan, People’s Republic of China; 4The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, People’s Republic of China; 5School of Life Sciences, Central South University, Changsha 410013, Hunan, People’s Republic of ChinaCorrespondence: Ai-Jing LuoThe Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Furong District, Changsha 410011, Hunan, People’s Republic of ChinaEmail 574224075@qq.comPurpose: To evaluate the perioperative complications of patients with cervical cancer who are treated with robot-assisted radical hysterectomy (RRH) and to further evaluate the safety of patients undergoing NACT.Methods: A total of 805 consecutive cervical cancer patients undergoing RRH were involved in this report. Their clinical characteristics were retrieved from hospital medical records. Perioperative complications were subdivided into intraoperative and postoperative complications, which were graded according to the Clavien–Dindo classification (CDC), and the complications of grade III and above were defined as severe complications. Furthermore, the two-level logistic regression model was used to estimate the risk factors of perioperative and severe complications and to further confirm the relationship between NACT and perioperative and severe complications.Results: The perioperative complication rate and severe complications were 45.09% and 7.83%, respectively. Poorly differentiated tumor and NACT were identified as independent risk factors for perioperative complications by multifactor analysis. Furthermore, we concentrated on the relations between NACT and complications. The risk of perioperative complications of the group with NACT (OR = 11.08, 95% CI: 5.70– 21.54) was significantly higher than the group without NACT, especially in postoperative complications (OR=17.65, 95% CI: 8.63– 36.08), even after adjusting confounding factors. However, there was no statistically significant difference in terms of severe complications (OR=1.68, 95% CI: 0.64– 4.41) and intraoperative complications (OR=0.51, 95% CI: 0.18– 1.41). Moreover, as the times of NACT increase, the impact on perioperative complications is more pronounced. A similar trend was observed in postoperative complications, while this statistical difference was still not observed in intraoperative and severe complications.Conclusion: This result demonstrates the feasibility and safety of RRH of cervical carcinoma after NACT in generally, since it only causes mild complications, not severe complications.Keywords: cervical carcinoma, robot-assisted radical hysterectomy, neoadjuvant chemotherapy, Clavien–Dindo classification, perioperative complicationshttps://www.dovepress.com/perioperative-complications-and-safety-evaluation-of-robot-assisted-ra-peer-reviewed-article-CMARcervical carcinomarobot-assisted radical hysterectomyneoadjuvant chemotherapyclavien–dindo classificationperioperative complications |
| spellingShingle | Chang WF Luo AJ Yuan YF Chen Y Xin ZR Xu SS Perioperative Complications and Safety Evaluation of Robot-Assisted Radical Hysterectomy of Cervical Cancer After Neoadjuvant Chemotherapy Cancer Management and Research cervical carcinoma robot-assisted radical hysterectomy neoadjuvant chemotherapy clavien–dindo classification perioperative complications |
| title | Perioperative Complications and Safety Evaluation of Robot-Assisted Radical Hysterectomy of Cervical Cancer After Neoadjuvant Chemotherapy |
| title_full | Perioperative Complications and Safety Evaluation of Robot-Assisted Radical Hysterectomy of Cervical Cancer After Neoadjuvant Chemotherapy |
| title_fullStr | Perioperative Complications and Safety Evaluation of Robot-Assisted Radical Hysterectomy of Cervical Cancer After Neoadjuvant Chemotherapy |
| title_full_unstemmed | Perioperative Complications and Safety Evaluation of Robot-Assisted Radical Hysterectomy of Cervical Cancer After Neoadjuvant Chemotherapy |
| title_short | Perioperative Complications and Safety Evaluation of Robot-Assisted Radical Hysterectomy of Cervical Cancer After Neoadjuvant Chemotherapy |
| title_sort | perioperative complications and safety evaluation of robot assisted radical hysterectomy of cervical cancer after neoadjuvant chemotherapy |
| topic | cervical carcinoma robot-assisted radical hysterectomy neoadjuvant chemotherapy clavien–dindo classification perioperative complications |
| url | https://www.dovepress.com/perioperative-complications-and-safety-evaluation-of-robot-assisted-ra-peer-reviewed-article-CMAR |
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