Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules.

Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules.

RIG-I triggers antiviral responses by recognizing viral RNA (vRNA) in the cytoplasm. However, the spatio-temporal dynamics of vRNA sensing and signal transduction remain elusive. We investigated the time course of events in cells infected with Newcastle disease virus (NDV), a non-segmented negative-...

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Bibliographic Details
Main Authors: Seong-Wook Oh, Koji Onomoto, Mai Wakimoto, Kazuhide Onoguchi, Fumiyoshi Ishidate, Takahiro Fujiwara, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4749238?pdf=render

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