Shaking alone induces de novo conversion of recombinant prion proteins to β-sheet rich oligomers and fibrils.

Shaking alone induces de novo conversion of recombinant prion proteins to β-sheet rich oligomers and fibrils.

The formation of β-sheet rich prion oligomers and fibrils from native prion protein (PrP) is thought to be a key step in the development of prion diseases. Many methods are available to convert recombinant prion protein into β-sheet rich fibrils using various chemical denaturants (urea, SDS, GdnHCl)...

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Bibliographic Details
Main Authors: Carol L Ladner-Keay, Bethany J Griffith, David S Wishart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4043794?pdf=render

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