Laparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review
Abstract Background Hepatic epithelioid hemangioendothelioma (HEHE) is an extremely rare borderline tumor of vascular endothelial origin. Laparoscopic resection of HEHE has never been reported. Methods The clinical data of eleven patients with HEHE (4 women and 7 men) who were diagnosed and treated...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | http://link.springer.com/article/10.1186/s12957-020-02034-z |
| _version_ | 1818257341314760704 |
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| author | Jianjun Xu Shaobo Hu Suzhen Li Weimin Wang Xing Zhou Yuzhe Wu Zhe Su Xiang Cheng Yang Gao Qichang Zheng |
| author_facet | Jianjun Xu Shaobo Hu Suzhen Li Weimin Wang Xing Zhou Yuzhe Wu Zhe Su Xiang Cheng Yang Gao Qichang Zheng |
| author_sort | Jianjun Xu |
| collection | DOAJ |
| description | Abstract Background Hepatic epithelioid hemangioendothelioma (HEHE) is an extremely rare borderline tumor of vascular endothelial origin. Laparoscopic resection of HEHE has never been reported. Methods The clinical data of eleven patients with HEHE (4 women and 7 men) who were diagnosed and treated at the Union Hospital (Wuhan, China), and Wuhan Asia General Hospital (Wuhan, China), between March 2012 and July 2020 were analyzed retrospectively. Results The mean age of HEHE patients was 42.4 ± 13.9 years (range 22–67 years). All patients underwent laparoscopic surgery alone or in combination with radiofrequency ablation. Most tumors showed aggressive growth or metastasis. By immunohistochemistry, tumor cells were positive for CD31, CD34, ERG, PCK, FLi-1, TFE-3, and Ki-67 (labeling index range, 5–15%). In one of the patients, the tumor was accompanied by partial necrosis with a local appearance of epithelioid angiosarcoma. Postoperative adjuvant treatment included chemotherapy, sorafenib, and Huaier granule. As of July 2020, the median follow-up duration was 36 months (range, 9–60 months), with 2 (18.2%) patients experiencing tumor recurrence. Conclusions This is the first report of laparoscopic hepatectomy of HEHE. Curative laparoscopic hepatectomy might be an acceptable treatment for appropriate HEHE patients. |
| first_indexed | 2024-12-12T17:42:07Z |
| format | Article |
| id | doaj.art-af4eb059a8564acbb4927ce9d52b180b |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-12T17:42:07Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-af4eb059a8564acbb4927ce9d52b180b2022-12-22T00:17:03ZengBMCWorld Journal of Surgical Oncology1477-78192020-10-011811810.1186/s12957-020-02034-zLaparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature reviewJianjun Xu0Shaobo Hu1Suzhen Li2Weimin Wang3Xing Zhou4Yuzhe Wu5Zhe Su6Xiang Cheng7Yang Gao8Qichang Zheng9Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastroenterology, Wuhan Asia General HospitalDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Hepatic epithelioid hemangioendothelioma (HEHE) is an extremely rare borderline tumor of vascular endothelial origin. Laparoscopic resection of HEHE has never been reported. Methods The clinical data of eleven patients with HEHE (4 women and 7 men) who were diagnosed and treated at the Union Hospital (Wuhan, China), and Wuhan Asia General Hospital (Wuhan, China), between March 2012 and July 2020 were analyzed retrospectively. Results The mean age of HEHE patients was 42.4 ± 13.9 years (range 22–67 years). All patients underwent laparoscopic surgery alone or in combination with radiofrequency ablation. Most tumors showed aggressive growth or metastasis. By immunohistochemistry, tumor cells were positive for CD31, CD34, ERG, PCK, FLi-1, TFE-3, and Ki-67 (labeling index range, 5–15%). In one of the patients, the tumor was accompanied by partial necrosis with a local appearance of epithelioid angiosarcoma. Postoperative adjuvant treatment included chemotherapy, sorafenib, and Huaier granule. As of July 2020, the median follow-up duration was 36 months (range, 9–60 months), with 2 (18.2%) patients experiencing tumor recurrence. Conclusions This is the first report of laparoscopic hepatectomy of HEHE. Curative laparoscopic hepatectomy might be an acceptable treatment for appropriate HEHE patients.http://link.springer.com/article/10.1186/s12957-020-02034-zHepatic epithelioid hemangioendotheliomaLiver neoplasmsLaparoscopic hepatectomyTargeted therapy |
| spellingShingle | Jianjun Xu Shaobo Hu Suzhen Li Weimin Wang Xing Zhou Yuzhe Wu Zhe Su Xiang Cheng Yang Gao Qichang Zheng Laparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review World Journal of Surgical Oncology Hepatic epithelioid hemangioendothelioma Liver neoplasms Laparoscopic hepatectomy Targeted therapy |
| title | Laparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review |
| title_full | Laparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review |
| title_fullStr | Laparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review |
| title_full_unstemmed | Laparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review |
| title_short | Laparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review |
| title_sort | laparoscopic resection of hepatic epithelioid hemangioendothelioma report of eleven rare cases and literature review |
| topic | Hepatic epithelioid hemangioendothelioma Liver neoplasms Laparoscopic hepatectomy Targeted therapy |
| url | http://link.springer.com/article/10.1186/s12957-020-02034-z |
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