RET rearrangements are actionable alterations in breast cancer
Fusions of the gene RET have been described in thyroid and lung cancers. Here, the AUs identify RET gene alterations, including known fusions, novel fusions, and rearrangements in breast cancer (BC) that are involved in the tumorigenic process and show the benefit of RET therapy in a recurrent BC pa...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07341-4 |
| _version_ | 1818990788813520896 |
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| author | Bhavna S. Paratala Jon H. Chung Casey B. Williams Bahar Yilmazel Whitney Petrosky Kirstin Williams Alexa B. Schrock Laurie M. Gay Ellen Lee Sonia C. Dolfi Kien Pham Stephanie Lin Ming Yao Atul Kulkarni Frances DiClemente Chen Liu Lorna Rodriguez-Rodriguez Shridar Ganesan Jeffrey S. Ross Siraj M. Ali Brian Leyland-Jones Kim M. Hirshfield |
| author_facet | Bhavna S. Paratala Jon H. Chung Casey B. Williams Bahar Yilmazel Whitney Petrosky Kirstin Williams Alexa B. Schrock Laurie M. Gay Ellen Lee Sonia C. Dolfi Kien Pham Stephanie Lin Ming Yao Atul Kulkarni Frances DiClemente Chen Liu Lorna Rodriguez-Rodriguez Shridar Ganesan Jeffrey S. Ross Siraj M. Ali Brian Leyland-Jones Kim M. Hirshfield |
| author_sort | Bhavna S. Paratala |
| collection | DOAJ |
| description | Fusions of the gene RET have been described in thyroid and lung cancers. Here, the AUs identify RET gene alterations, including known fusions, novel fusions, and rearrangements in breast cancer (BC) that are involved in the tumorigenic process and show the benefit of RET therapy in a recurrent BC patient carrying the NCOA4-RET fusion. |
| first_indexed | 2024-12-20T19:59:57Z |
| format | Article |
| id | doaj.art-af4ef9c2d18542d6986221a4da000c4e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T19:59:57Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-af4ef9c2d18542d6986221a4da000c4e2022-12-21T19:28:04ZengNature PortfolioNature Communications2041-17232018-11-019111310.1038/s41467-018-07341-4RET rearrangements are actionable alterations in breast cancerBhavna S. Paratala0Jon H. Chung1Casey B. Williams2Bahar Yilmazel3Whitney Petrosky4Kirstin Williams5Alexa B. Schrock6Laurie M. Gay7Ellen Lee8Sonia C. Dolfi9Kien Pham10Stephanie Lin11Ming Yao12Atul Kulkarni13Frances DiClemente14Chen Liu15Lorna Rodriguez-Rodriguez16Shridar Ganesan17Jeffrey S. Ross18Siraj M. Ali19Brian Leyland-Jones20Kim M. Hirshfield21Department of Medicine, Division of Medical Oncology, Rutgers Cancer Institute of New JerseyFoundation MedicineAvera Cancer Institute Center for Precision OncologyFoundation MedicineDepartment of Medicine, Division of Medical Oncology, Rutgers Cancer Institute of New JerseyAvera Cancer Institute Center for Precision OncologyFoundation MedicineFoundation MedicineUniversity Radiology GroupDepartment of Medicine, Division of Medical Oncology, Rutgers Cancer Institute of New JerseyDepartment of Pathology and Laboratory Medicine, Rutgers New Jersey Medical School and Rutgers Robert Wood Johnson Medical SchoolDepartment of Medicine, Division of Medical Oncology, Rutgers Cancer Institute of New JerseyDepartment of Medicine, Division of Medical Oncology, Rutgers Cancer Institute of New JerseyDepartment of Medicine, Division of Medical Oncology, Rutgers Cancer Institute of New JerseyDepartment of Medicine, Division of Medical Oncology, Rutgers Cancer Institute of New JerseyDepartment of Pathology and Laboratory Medicine, Rutgers New Jersey Medical School and Rutgers Robert Wood Johnson Medical SchoolRutgers UniversityDepartment of Medicine, Division of Medical Oncology, Rutgers Cancer Institute of New JerseyFoundation MedicineFoundation MedicineAvera Cancer Institute Center for Precision OncologyDepartment of Medicine, Division of Medical Oncology, Rutgers Cancer Institute of New JerseyFusions of the gene RET have been described in thyroid and lung cancers. Here, the AUs identify RET gene alterations, including known fusions, novel fusions, and rearrangements in breast cancer (BC) that are involved in the tumorigenic process and show the benefit of RET therapy in a recurrent BC patient carrying the NCOA4-RET fusion.https://doi.org/10.1038/s41467-018-07341-4 |
| spellingShingle | Bhavna S. Paratala Jon H. Chung Casey B. Williams Bahar Yilmazel Whitney Petrosky Kirstin Williams Alexa B. Schrock Laurie M. Gay Ellen Lee Sonia C. Dolfi Kien Pham Stephanie Lin Ming Yao Atul Kulkarni Frances DiClemente Chen Liu Lorna Rodriguez-Rodriguez Shridar Ganesan Jeffrey S. Ross Siraj M. Ali Brian Leyland-Jones Kim M. Hirshfield RET rearrangements are actionable alterations in breast cancer Nature Communications |
| title | RET rearrangements are actionable alterations in breast cancer |
| title_full | RET rearrangements are actionable alterations in breast cancer |
| title_fullStr | RET rearrangements are actionable alterations in breast cancer |
| title_full_unstemmed | RET rearrangements are actionable alterations in breast cancer |
| title_short | RET rearrangements are actionable alterations in breast cancer |
| title_sort | ret rearrangements are actionable alterations in breast cancer |
| url | https://doi.org/10.1038/s41467-018-07341-4 |
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