Detecting T-cell clonal expansions and quantifying clone survival using deep profiling of immune repertoires

Detecting T-cell clonal expansions and quantifying clone survival using deep profiling of immune repertoires

An individual’s T-cell repertoire constantly changes under the influence of external and internal factors. Cells that do not receive a stimulatory signal die, while those that encounter and recognize a pathogen or receive a co-stimulatory signal divide, resulting in clonal expansions. T-cell clones...

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Bibliographic Details
Main Authors:	Anastasia V. Pavlova, Ivan V. Zvyagin, Mikhail Shugay
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Series:	Frontiers in Immunology
Subjects:	T cell repertoire analysis adaptive immune receptor repertoire (AIRR) T cell receptor (TCR) clonal tracking hematopoietic (stem) cell transplantation (HCST) immune reconstitution
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1321603/full

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