Neural Transplantation in Huntington's Disease: The NEST-UK Donor Tissue Microbiological Screening Program and Review of the Literature
Neural transplantation of human fetal tissue for Huntington's disease (HD) is now entering the clinical arena. The safety of the procedure has now been demonstrated in a number of studies, although the efficacy of such an approach is still being investigated. Stringent but practicable screening...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2006-04-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/000000006783981927 |
| _version_ | 1818342412308709376 |
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| author | M. Farrington T. G. Wreghitt A. M. L. Lever S. B. Dunnett A. E. Rosser R. A. Barker |
| author_facet | M. Farrington T. G. Wreghitt A. M. L. Lever S. B. Dunnett A. E. Rosser R. A. Barker |
| author_sort | M. Farrington |
| collection | DOAJ |
| description | Neural transplantation of human fetal tissue for Huntington's disease (HD) is now entering the clinical arena. The safety of the procedure has now been demonstrated in a number of studies, although the efficacy of such an approach is still being investigated. Stringent but practicable screening of the donor tissue for potential pathogens is an essential prerequisite for successful implementation of any novel transplant program that uses human fetal tissue. In this article we summarize the UK-NEST protocol for the screening of human fetal tissue being grafted to patients with mild to moderate HD. We describe the results of microbiological screening of 87 potential tissue donors in a pilot study, and of the first four donor–recipient patients included in the UK-NEST series. The rationale for the adoption and interpretation of the various tests is described and our methodology is compared with those previously used by other centers. This article therefore presents a comprehensive, logical yet pragmatic screening program that could be employed in any clinical studies that use human fetal tissue for neurotransplantation. |
| first_indexed | 2024-12-13T16:14:17Z |
| format | Article |
| id | doaj.art-af51b35d6a3c4a848df1e95dd41b6132 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-13T16:14:17Z |
| publishDate | 2006-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-af51b35d6a3c4a848df1e95dd41b61322022-12-21T23:38:52ZengSAGE PublishingCell Transplantation0963-68971555-38922006-04-011510.3727/000000006783981927Neural Transplantation in Huntington's Disease: The NEST-UK Donor Tissue Microbiological Screening Program and Review of the LiteratureM. Farrington0T. G. Wreghitt1A. M. L. Lever2S. B. Dunnett3A. E. Rosser4R. A. Barker5Clinical Microbiology and Public Health Laboratory, Health Protection Agency & Addenbrooke's Hospital, Cambridge, UKClinical Microbiology and Public Health Laboratory, Health Protection Agency & Addenbrooke's Hospital, Cambridge, UKDepartment of Medicine, University of Cambridge, Cambridge, UKSchool of Biosciences, Cardiff University, Cardiff, UKSchool of Biosciences, Cardiff University, Cardiff, UKDepartment of Neurology, University of Cambridge, Cambridge, UKNeural transplantation of human fetal tissue for Huntington's disease (HD) is now entering the clinical arena. The safety of the procedure has now been demonstrated in a number of studies, although the efficacy of such an approach is still being investigated. Stringent but practicable screening of the donor tissue for potential pathogens is an essential prerequisite for successful implementation of any novel transplant program that uses human fetal tissue. In this article we summarize the UK-NEST protocol for the screening of human fetal tissue being grafted to patients with mild to moderate HD. We describe the results of microbiological screening of 87 potential tissue donors in a pilot study, and of the first four donor–recipient patients included in the UK-NEST series. The rationale for the adoption and interpretation of the various tests is described and our methodology is compared with those previously used by other centers. This article therefore presents a comprehensive, logical yet pragmatic screening program that could be employed in any clinical studies that use human fetal tissue for neurotransplantation.https://doi.org/10.3727/000000006783981927 |
| spellingShingle | M. Farrington T. G. Wreghitt A. M. L. Lever S. B. Dunnett A. E. Rosser R. A. Barker Neural Transplantation in Huntington's Disease: The NEST-UK Donor Tissue Microbiological Screening Program and Review of the Literature Cell Transplantation |
| title | Neural Transplantation in Huntington's Disease: The NEST-UK Donor Tissue Microbiological Screening Program and Review of the Literature |
| title_full | Neural Transplantation in Huntington's Disease: The NEST-UK Donor Tissue Microbiological Screening Program and Review of the Literature |
| title_fullStr | Neural Transplantation in Huntington's Disease: The NEST-UK Donor Tissue Microbiological Screening Program and Review of the Literature |
| title_full_unstemmed | Neural Transplantation in Huntington's Disease: The NEST-UK Donor Tissue Microbiological Screening Program and Review of the Literature |
| title_short | Neural Transplantation in Huntington's Disease: The NEST-UK Donor Tissue Microbiological Screening Program and Review of the Literature |
| title_sort | neural transplantation in huntington s disease the nest uk donor tissue microbiological screening program and review of the literature |
| url | https://doi.org/10.3727/000000006783981927 |
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