| Summary: | Objective To observe the effectiveness and safety of nalbuphine combined with propofol in children with painless colonoscopy. Methods A total of 90 children aged 3 to 6 years from the Children's Hospital of Chongqing Medical University who underwent painless colonoscopy from May to October 2020 were recruited, and then randomly divided into nalbuphine group (N group, n=45, 0.3 mg/kg nalbuphine injected intravenously with combination of 3 mg/kg propofol) and sufentanil group (S group, n=45, 0.2 μg/kg sufentanil injected intravenously with combination of 3 mg/kg propofol). According to the procedure of colonoscopy, the changes in vital signs were observed in the 2 groups of children at various time points. Induction time (IT), examination time (total scan time, ST), recovery time (RT), analgesic effect and incidence of adverse reactions were also recorded. Results There were no statistical differences in gender, age, body weight, status of American Society of Anesthesiologists (ASA) classification, operation type and number of polyps between the 2 groups (P>0.05). The vital signs were significantly lower in the 2 groups in 3 min after the analgesic administration (T1) than immediately before the administration (T0) (P < 0.05). The N group had obviously higher respiratory rate (P < 0.05) and oxygen saturation at T1 (P < 0.05), but shorter recovery time when compared with the S group (P < 0.01). However, there was no notable difference in the analgesic effect between the 2 groups. No adverse reactions were observed in the N group, and coughing was seen in 5 cases of the S group. No serious complications occurred in the 2 groups. Conclusion Nalbuphine combined with propofol has good sedative and analgesic effects in painless colonoscopy for children, with little impact on breathing, low incidence of adverse reactions and quick recovery.
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