Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis
Despite extensive research reveal rheumatoid arthritis (RA) is related to atherosclerosis (AS), common pathogenesis between these two diseases still needs to be explored. In current study, we explored the common pathogenesis between rheumatoid arthritis (RA) and atherosclerosis (AS) by identifying 2...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402404060X |
| _version_ | 1797213402357039104 |
|---|---|
| author | Fan Xu Linfeng Xie Jian He Qiuyu Huang Yanming Shen Liangwan Chen Xiaohong Zeng |
| author_facet | Fan Xu Linfeng Xie Jian He Qiuyu Huang Yanming Shen Liangwan Chen Xiaohong Zeng |
| author_sort | Fan Xu |
| collection | DOAJ |
| description | Despite extensive research reveal rheumatoid arthritis (RA) is related to atherosclerosis (AS), common pathogenesis between these two diseases still needs to be explored. In current study, we explored the common pathogenesis between rheumatoid arthritis (RA) and atherosclerosis (AS) by identifying 297 Differentially Expressed Genes (DEGs) associated with both diseases. Through KEGG and GO functional analysis, we highlighted the correlation of these DEGs with crucial biological processes such as the vesicle transport, immune system process, signaling receptor binding, chemokine signaling and many others. Employing Protein-Protein Interaction (PPI) network analysis, we elucidated the associations between DEGs, revealing three gene modules enriched in immune system process, vesicle, signaling receptor binding, Pertussis, and among others. Additionally, through CytoHubba analysis, we pinpointed 11 hub genes integral to intergrin-mediated signaling pathway, plasma membrane, phosphotyrosine binding, chemokine signaling pathway and so on. Further investigation via the TRRUST database identified two key Transcription Factors (TFs), SPI1 and RELA, closely linked with these hub genes, shedding light on their regulatory roles. Finally, leveraging the collective insights from hub genes and TFs, we proposed 10 potential drug candidates targeting the molecular mechanisms underlying RA and AS pathogenesis. Further investigation on xCell revealed that 14 types of cells were all different in both AS and RA. This study underscores the shared pathogenic mechanisms, pivotal genes, and potential therapeutic interventions bridging RA and AS, offering valuable insights for future research and clinical management strategies. |
| first_indexed | 2024-04-24T10:57:42Z |
| format | Article |
| id | doaj.art-af52fa058e2e4dc7802928a458d17abb |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T10:57:42Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-af52fa058e2e4dc7802928a458d17abb2024-04-12T04:45:28ZengElsevierHeliyon2405-84402024-04-01108e28029Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysisFan Xu0Linfeng Xie1Jian He2Qiuyu Huang3Yanming Shen4Liangwan Chen5Xiaohong Zeng6Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian Province, ChinaDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China; Fujian Medical University, Fuzhou, Fujian Province, ChinaDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China; Fujian Medical University, Fuzhou, Fujian Province, ChinaDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian Province, ChinaDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China; Fujian Medical University, Fuzhou, Fujian Province, ChinaDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian Province, China; Corresponding author. Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, XinQuan Road No. 29, Fuzhou, 350001, China.Department of Rheumatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China; Corresponding author. Department of Rheumatology, the First Affiliated Hospital of Fujian Medical University, ChaZhong Road No. 20, Fuzhou, 350001, China.Despite extensive research reveal rheumatoid arthritis (RA) is related to atherosclerosis (AS), common pathogenesis between these two diseases still needs to be explored. In current study, we explored the common pathogenesis between rheumatoid arthritis (RA) and atherosclerosis (AS) by identifying 297 Differentially Expressed Genes (DEGs) associated with both diseases. Through KEGG and GO functional analysis, we highlighted the correlation of these DEGs with crucial biological processes such as the vesicle transport, immune system process, signaling receptor binding, chemokine signaling and many others. Employing Protein-Protein Interaction (PPI) network analysis, we elucidated the associations between DEGs, revealing three gene modules enriched in immune system process, vesicle, signaling receptor binding, Pertussis, and among others. Additionally, through CytoHubba analysis, we pinpointed 11 hub genes integral to intergrin-mediated signaling pathway, plasma membrane, phosphotyrosine binding, chemokine signaling pathway and so on. Further investigation via the TRRUST database identified two key Transcription Factors (TFs), SPI1 and RELA, closely linked with these hub genes, shedding light on their regulatory roles. Finally, leveraging the collective insights from hub genes and TFs, we proposed 10 potential drug candidates targeting the molecular mechanisms underlying RA and AS pathogenesis. Further investigation on xCell revealed that 14 types of cells were all different in both AS and RA. This study underscores the shared pathogenic mechanisms, pivotal genes, and potential therapeutic interventions bridging RA and AS, offering valuable insights for future research and clinical management strategies.http://www.sciencedirect.com/science/article/pii/S240584402404060XRheumatoid arthritisAtherosclerosisBioinformaticsDifferentially expressed genesHub genes |
| spellingShingle | Fan Xu Linfeng Xie Jian He Qiuyu Huang Yanming Shen Liangwan Chen Xiaohong Zeng Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis Heliyon Rheumatoid arthritis Atherosclerosis Bioinformatics Differentially expressed genes Hub genes |
| title | Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis |
| title_full | Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis |
| title_fullStr | Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis |
| title_full_unstemmed | Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis |
| title_short | Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis |
| title_sort | detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis |
| topic | Rheumatoid arthritis Atherosclerosis Bioinformatics Differentially expressed genes Hub genes |
| url | http://www.sciencedirect.com/science/article/pii/S240584402404060X |
| work_keys_str_mv | AT fanxu detectionofcommonpathogenesisofrheumatoidarthritisandatherosclerosisviamicroarraydataanalysis AT linfengxie detectionofcommonpathogenesisofrheumatoidarthritisandatherosclerosisviamicroarraydataanalysis AT jianhe detectionofcommonpathogenesisofrheumatoidarthritisandatherosclerosisviamicroarraydataanalysis AT qiuyuhuang detectionofcommonpathogenesisofrheumatoidarthritisandatherosclerosisviamicroarraydataanalysis AT yanmingshen detectionofcommonpathogenesisofrheumatoidarthritisandatherosclerosisviamicroarraydataanalysis AT liangwanchen detectionofcommonpathogenesisofrheumatoidarthritisandatherosclerosisviamicroarraydataanalysis AT xiaohongzeng detectionofcommonpathogenesisofrheumatoidarthritisandatherosclerosisviamicroarraydataanalysis |