Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups
Abstract Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2413 |
| _version_ | 1818987470984839168 |
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| author | Ashley N. Clausen Kelene A. Fercho Molly Monsour Seth Disner Lauren Salminen Courtney C. Haswell Emily Clarke Rubright Amanda A. Watts M. Nicole Buckley Adi Maron‐Katz Anika Sierk Antje Manthey Benjamin Suarez‐Jimenez Bunmi O. Olatunji Christopher L. Averill David Hofmann Dick J. Veltman Elizabeth A. Olson Gen Li Gina L. Forster Henrik Walter Jacklynn Fitzgerald Jean Théberge Jeffrey S. Simons Jessica A. Bomyea Jessie L. Frijling John H. Krystal Justin T. Baker K. Luan Phan Kerry Ressler Laura K. M. Han Laura Nawijn Lauren A. M. Lebois Lianne Schmaal Maria Densmore Martha E. Shenton Mirjam vanZuiden Murray Stein Negar Fani Raluca M. Simons Richard W. J. Neufeld Ruth Lanius Sanne vanRooij Saskia B.J. Koch Serena Bonomo Tanja Jovanovic Terri deRoon‐Cassini Timothy D. Ely Vincent A. Magnotta Xiaofu He Chadi G. Abdallah Amit Etkin Christian Schmahl Christine Larson Isabelle M. Rosso Jennifer Urbano Blackford Jennifer S. Stevens Judith K. Daniels Julia Herzog Milissa L. Kaufman Miranda Olff Richard J. Davidson Scott R. Sponheim Sven C. Mueller Thomas Straube Xi Zhu Yuval Neria Lee A. Baugh James H. Cole Paul M. Thompson Rajendra A. Morey |
| author_facet | Ashley N. Clausen Kelene A. Fercho Molly Monsour Seth Disner Lauren Salminen Courtney C. Haswell Emily Clarke Rubright Amanda A. Watts M. Nicole Buckley Adi Maron‐Katz Anika Sierk Antje Manthey Benjamin Suarez‐Jimenez Bunmi O. Olatunji Christopher L. Averill David Hofmann Dick J. Veltman Elizabeth A. Olson Gen Li Gina L. Forster Henrik Walter Jacklynn Fitzgerald Jean Théberge Jeffrey S. Simons Jessica A. Bomyea Jessie L. Frijling John H. Krystal Justin T. Baker K. Luan Phan Kerry Ressler Laura K. M. Han Laura Nawijn Lauren A. M. Lebois Lianne Schmaal Maria Densmore Martha E. Shenton Mirjam vanZuiden Murray Stein Negar Fani Raluca M. Simons Richard W. J. Neufeld Ruth Lanius Sanne vanRooij Saskia B.J. Koch Serena Bonomo Tanja Jovanovic Terri deRoon‐Cassini Timothy D. Ely Vincent A. Magnotta Xiaofu He Chadi G. Abdallah Amit Etkin Christian Schmahl Christine Larson Isabelle M. Rosso Jennifer Urbano Blackford Jennifer S. Stevens Judith K. Daniels Julia Herzog Milissa L. Kaufman Miranda Olff Richard J. Davidson Scott R. Sponheim Sven C. Mueller Thomas Straube Xi Zhu Yuval Neria Lee A. Baugh James H. Cole Paul M. Thompson Rajendra A. Morey |
| author_sort | Ashley N. Clausen |
| collection | DOAJ |
| description | Abstract Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects (N = 2229; 56.2% male) aged 18–69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA‐PGC PTSD sites underwent T1‐weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel‐wise (brainageR) and region‐of‐interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age − chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three‐way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age‐related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan. |
| first_indexed | 2024-12-20T19:07:12Z |
| format | Article |
| id | doaj.art-af5371d486a5431c82d155d69467d00c |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-20T19:07:12Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-af5371d486a5431c82d155d69467d00c2022-12-21T19:29:16ZengWileyBrain and Behavior2162-32792022-01-01121n/an/a10.1002/brb3.2413Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groupsAshley N. Clausen0Kelene A. Fercho1Molly Monsour2Seth Disner3Lauren Salminen4Courtney C. Haswell5Emily Clarke Rubright6Amanda A. Watts7M. Nicole Buckley8Adi Maron‐Katz9Anika Sierk10Antje Manthey11Benjamin Suarez‐Jimenez12Bunmi O. Olatunji13Christopher L. Averill14David Hofmann15Dick J. Veltman16Elizabeth A. Olson17Gen Li18Gina L. Forster19Henrik Walter20Jacklynn Fitzgerald21Jean Théberge22Jeffrey S. Simons23Jessica A. Bomyea24Jessie L. Frijling25John H. Krystal26Justin T. Baker27K. Luan Phan28Kerry Ressler29Laura K. M. Han30Laura Nawijn31Lauren A. M. Lebois32Lianne Schmaal33Maria Densmore34Martha E. Shenton35Mirjam vanZuiden36Murray Stein37Negar Fani38Raluca M. Simons39Richard W. J. Neufeld40Ruth Lanius41Sanne vanRooij42Saskia B.J. Koch43Serena Bonomo44Tanja Jovanovic45Terri deRoon‐Cassini46Timothy D. Ely47Vincent A. Magnotta48Xiaofu He49Chadi G. Abdallah50Amit Etkin51Christian Schmahl52Christine Larson53Isabelle M. Rosso54Jennifer Urbano Blackford55Jennifer S. Stevens56Judith K. Daniels57Julia Herzog58Milissa L. Kaufman59Miranda Olff60Richard J. Davidson61Scott R. Sponheim62Sven C. Mueller63Thomas Straube64Xi Zhu65Yuval Neria66Lee A. Baugh67James H. Cole68Paul M. Thompson69Rajendra A. Morey70VA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USACenter for Brain and Behavior Research University of South Dakota Vermillion South Dakota USADuke University Brain Imaging and Analysis Center Durham North Carolina USADepartment of Psychiatry University of Minnesota Medical School Minneapolis Minnesota USAImaging Genetics Center Mark & Mary Stevens Neuroimaging & Informatics Institute Keck School of Medicine University of Southern California Marina del Rey California USAVA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USAVA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USAVA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USAVA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USADepartment of Psychiatry and Behavioral Sciences Stanford University of Medicine Stanford California USAUniversity Medical Centre Charite Berlin GermanyUniversity Medical Centre Charite Berlin GermanyColumbia University Medical Center Manhattan New York USADepartment of Psychology Vanderbilt University Nashville Tennessee USAClinical Neuroscience Division National Center for PTSD West Haven Connecticut USAInstitute of Medical Psychology and Systems Neuroscience University of Muenster Muenster GermanyDepartment of Psychiatry Amsterdam University Medical Centers Location VU University Medical Center VU University Amsterdam The NetherlandsHarvard Medical School Boston Massachusetts USADepartment of Psychology University of Chinese Academy of Sciences Beijing ChinaBrain Health Research Centre Department of Anatomy University of Otago Dunedin New ZealandUniversity Medical Centre Charite Berlin GermanyMarquette University Milwaukee Wisconsin USADepartment of Medical Biophysics University of Western Ontario London Ontario CanadaCenter for Brain and Behavior Research University of South Dakota Vermillion South Dakota USAUC San Diego Department of Psychiatry San Deigo California USADepartment of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The NetherlandsClinical Neuroscience Division National Center for PTSD West Haven Connecticut USAInstitute for Technology in Psychiatry McLean Hospital Harvard University Belmont Massachusetts USADepartment of Psychiatry and Behavioral Health The Ohio State University Columbus Ohio USADepartment of Psychiatry Harvard Medical School Boston Massachusetts USADepartment of Psychiatry Amsterdam University Medical Centers VU University Medical Center GGZ inGeest Amsterdam Neuroscience Amsterdam The NetherlandsDepartment of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The NetherlandsDepartment of Psychiatry Harvard Medical School Boston Massachusetts USACentre for Youth Mental Health The University of Melbourne Melbourne AustraliaDepartment of Psychiatry Western University London Ontario CanadaDepartment of Psychiatry VA Boston Healthcare System Brockton Massachusetts USADepartment of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The NetherlandsUC San Diego Department of Family Medicine and Public Health San Deigo California USADepartment of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USACenter for Brain and Behavior Research University of South Dakota Vermillion South Dakota USADepartment of Neuroscience Western University London Ontario CanadaDepartment of Neuroscience Western University London Ontario CanadaDepartment of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USADepartment of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The NetherlandsNew York State Psychiatric Institute New York New York USADepartment of Psychiatry and Behavioral Neurosciences Wayne State University Detroit Michigan USAMedical College of Wisconsin Milwaukee Wisconsin USADepartment of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USADepartments of Radiology Psychiatry and Biomedical Engineering University of Iowa Iowa City Iowa USAColumbia University Medical Center Manhattan New York USAClinical Neuroscience Division National Center for PTSD West Haven Connecticut USADepartment of Psychiatry and Behavioral Sciences Stanford University of Medicine Stanford California USADepartment of Psychosomatic Medicine and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim/Heidelberg University Mannheim GermanyUniversity of Wisconsin‐Milwaukee Milwaukee Wisconsin USAHarvard Medical School Boston Massachusetts USADepartment of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center Nashville Tennessee USADepartment of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USAUniversity of Groningen The NetherlandsDepartment of Psychosomatic Medicine and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim/Heidelberg University Mannheim GermanyDivision of Women's Mental Health McLean Hospital Belmont Massachusetts USAARQ National Psychotrauma Centrum Diemen The NetherlandsCenter for Healthy Minds Departments of Psychology and Psychiatry University of Wisconsin‐Madison Madison Wisconsin USADepartment of Psychiatry University of Minnesota Medical School Minneapolis Minnesota USADepartment of Experimental Clinical and Health Psychology Ghent University Ghent BelgiumInstitute of Medical Psychology and Systems Neuroscience University of Muenster Muenster GermanyColumbia University Medical Center Manhattan New York USAColumbia University Medical Center Manhattan New York USACenter for Brain and Behavior Research University of South Dakota Vermillion South Dakota USACentre for Medical Image Computing Computer Science University College London London UKImaging Genetics Center Mark & Mary Stevens Neuroimaging & Informatics Institute Keck School of Medicine University of Southern California Marina del Rey California USAVA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USAAbstract Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects (N = 2229; 56.2% male) aged 18–69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA‐PGC PTSD sites underwent T1‐weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel‐wise (brainageR) and region‐of‐interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age − chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three‐way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age‐related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan.https://doi.org/10.1002/brb3.2413agingmachine learningmega‐analysisneuroimagingposttraumatic stress disordertrauma |
| spellingShingle | Ashley N. Clausen Kelene A. Fercho Molly Monsour Seth Disner Lauren Salminen Courtney C. Haswell Emily Clarke Rubright Amanda A. Watts M. Nicole Buckley Adi Maron‐Katz Anika Sierk Antje Manthey Benjamin Suarez‐Jimenez Bunmi O. Olatunji Christopher L. Averill David Hofmann Dick J. Veltman Elizabeth A. Olson Gen Li Gina L. Forster Henrik Walter Jacklynn Fitzgerald Jean Théberge Jeffrey S. Simons Jessica A. Bomyea Jessie L. Frijling John H. Krystal Justin T. Baker K. Luan Phan Kerry Ressler Laura K. M. Han Laura Nawijn Lauren A. M. Lebois Lianne Schmaal Maria Densmore Martha E. Shenton Mirjam vanZuiden Murray Stein Negar Fani Raluca M. Simons Richard W. J. Neufeld Ruth Lanius Sanne vanRooij Saskia B.J. Koch Serena Bonomo Tanja Jovanovic Terri deRoon‐Cassini Timothy D. Ely Vincent A. Magnotta Xiaofu He Chadi G. Abdallah Amit Etkin Christian Schmahl Christine Larson Isabelle M. Rosso Jennifer Urbano Blackford Jennifer S. Stevens Judith K. Daniels Julia Herzog Milissa L. Kaufman Miranda Olff Richard J. Davidson Scott R. Sponheim Sven C. Mueller Thomas Straube Xi Zhu Yuval Neria Lee A. Baugh James H. Cole Paul M. Thompson Rajendra A. Morey Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups Brain and Behavior aging machine learning mega‐analysis neuroimaging posttraumatic stress disorder trauma |
| title | Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups |
| title_full | Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups |
| title_fullStr | Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups |
| title_full_unstemmed | Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups |
| title_short | Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups |
| title_sort | assessment of brain age in posttraumatic stress disorder findings from the enigma ptsd and brain age working groups |
| topic | aging machine learning mega‐analysis neuroimaging posttraumatic stress disorder trauma |
| url | https://doi.org/10.1002/brb3.2413 |
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