Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy
<b>AIM:</b>To measure changes of total oxidant status (TOS) and total antioxidant capacity (TAC) of aqueous humor (AH) in diabetic retinopathy (DR) patients, and to determine if there were any differences in TOS and TAC of AH in diabetic patients without retinopathy compared with non-dia...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2013-08-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2013/4/20130423.pdf |
| _version_ | 1819264141434552320 |
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| author | Emrullah Beyazyıldız Ali Bülent Çankaya Esra Ergan Mustafa Alparslan Anayol Yasemin Özdamar Sevilay Sezer Mehmet Hakan Tırhış Pelin Yılmazbaş Faruk Öztürk |
| author_facet | Emrullah Beyazyıldız Ali Bülent Çankaya Esra Ergan Mustafa Alparslan Anayol Yasemin Özdamar Sevilay Sezer Mehmet Hakan Tırhış Pelin Yılmazbaş Faruk Öztürk |
| author_sort | Emrullah Beyazyıldız |
| collection | DOAJ |
| description | <b>AIM:</b>To measure changes of total oxidant status (TOS) and total antioxidant capacity (TAC) of aqueous humor (AH) in diabetic retinopathy (DR) patients, and to determine if there were any differences in TOS and TAC of AH in diabetic patients without retinopathy compared with non-diabetic patients. <b>METHODS:</b>One hundred and three eyes of 103 patients who were enrolled for cataract surgery were included in this study. Patients were grouped according to presence of diabetes and stage of DR. Prior to cataract surgery, 0.1mL to 0.2mL of AH was aspirated and analyzed for TAC and TOS level using a colorimetric method. <b>RESULTS:</b>TOS levels were highest among proliferative diabetic retinopathy (PDR) patients and lowest in patients with only cataracts. Results were statistically significant between all groups (<i>P</i><0.05). Whereas result between diabetic without retinopathy patients and non-proliferative diabetic retinopathy (NPDR) patients was not statistically significant (<i>P</i>=0.757). TAC levels were highest in patients with only cataract and lowest among PDR patients and results were statistically significant between all groups (<i>P</i><0.05). <b>CONCLUSION:</b>Aqueous humor TAC levels are low in diabetic patients and reduced further in DR patients, TOS levels are increased in diabetic patients and this is exacerbated in DR patients. |
| first_indexed | 2024-12-23T20:24:46Z |
| format | Article |
| id | doaj.art-af58f667adf14492a25d811adc7dd914 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-23T20:24:46Z |
| publishDate | 2013-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-af58f667adf14492a25d811adc7dd9142022-12-21T17:32:26ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982013-08-016453153610.3980/j.issn.2222-3959.2013.04.23Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathyEmrullah BeyazyıldızAli Bülent ÇankayaEsra ErganMustafa Alparslan AnayolYasemin ÖzdamarSevilay SezerMehmet Hakan TırhışPelin YılmazbaşFaruk Öztürk<b>AIM:</b>To measure changes of total oxidant status (TOS) and total antioxidant capacity (TAC) of aqueous humor (AH) in diabetic retinopathy (DR) patients, and to determine if there were any differences in TOS and TAC of AH in diabetic patients without retinopathy compared with non-diabetic patients. <b>METHODS:</b>One hundred and three eyes of 103 patients who were enrolled for cataract surgery were included in this study. Patients were grouped according to presence of diabetes and stage of DR. Prior to cataract surgery, 0.1mL to 0.2mL of AH was aspirated and analyzed for TAC and TOS level using a colorimetric method. <b>RESULTS:</b>TOS levels were highest among proliferative diabetic retinopathy (PDR) patients and lowest in patients with only cataracts. Results were statistically significant between all groups (<i>P</i><0.05). Whereas result between diabetic without retinopathy patients and non-proliferative diabetic retinopathy (NPDR) patients was not statistically significant (<i>P</i>=0.757). TAC levels were highest in patients with only cataract and lowest among PDR patients and results were statistically significant between all groups (<i>P</i><0.05). <b>CONCLUSION:</b>Aqueous humor TAC levels are low in diabetic patients and reduced further in DR patients, TOS levels are increased in diabetic patients and this is exacerbated in DR patients.http://www.ijo.cn/en_publish/2013/4/20130423.pdfaqueous humordiabetic retinopathytotal antioxidant capacitytotal oxidant status |
| spellingShingle | Emrullah Beyazyıldız Ali Bülent Çankaya Esra Ergan Mustafa Alparslan Anayol Yasemin Özdamar Sevilay Sezer Mehmet Hakan Tırhış Pelin Yılmazbaş Faruk Öztürk Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy International Journal of Ophthalmology aqueous humor diabetic retinopathy total antioxidant capacity total oxidant status |
| title | Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy |
| title_full | Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy |
| title_fullStr | Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy |
| title_full_unstemmed | Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy |
| title_short | Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy |
| title_sort | changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy |
| topic | aqueous humor diabetic retinopathy total antioxidant capacity total oxidant status |
| url | http://www.ijo.cn/en_publish/2013/4/20130423.pdf |
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