The impact of enteral feeding and therapeutic monitoring of rifampicin with dose escalation in critically ill patients with tuberculosis

The impact of enteral feeding and therapeutic monitoring of rifampicin with dose escalation in critically ill patients with tuberculosis

Objectives: Critically ill patients with tuberculosis (TB) face a high mortality risk and require effective treatment. There is a paucity of data on rifampicin pharmacokinetics, the impact of continuous enteral feeding on drug absorption, and the potential of therapeutic drug monitoring (TDM) to opt...

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Bibliographic Details
Main Authors: Rubeshan Perumal, Kogieleum Naidoo, Anushka Naidoo, Marothi P. Letsoalo, Aliasgar Esmail, Ivan Joubert, Paolo Denti, Lubbe Wiesner, Nesri Padayatchi, Gary Maartens, Keertan Dheda
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:International Journal of Infectious Diseases
Subjects:
Pharmacokinetics
Critical illness
Dose-adjustment
High-dose rifampicin
Personalized medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971222006269

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http://www.sciencedirect.com/science/article/pii/S1201971222006269

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