Platelet Count is Associated with the Rate of Lymph Node Metastasis in Lung Adenocarcinoma

Cheng-hao Qu,1,2 Tong Li,1,2 Zhan-peng Tang,1,2 Xi-Rui Zhu,1,2 Jing-yi Han,1,2 Hui Tian2 1Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China; 2Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University,...

Full description

Bibliographic Details
Main Authors: Qu C, Li T, Tang Z, Zhu XR, Han J, Tian H
Format: Article
Language:English
Published: Dove Medical Press 2020-10-01
Series:Cancer Management and Research
Subjects:
Online Access:https://www.dovepress.com/platelet-count-is-associated-with-the-rate-of-lymph-node-metastasis-in-peer-reviewed-article-CMAR
_version_ 1818113174948282368
author Qu C
Li T
Tang Z
Zhu XR
Han J
Tian H
author_facet Qu C
Li T
Tang Z
Zhu XR
Han J
Tian H
author_sort Qu C
collection DOAJ
description Cheng-hao Qu,1,2 Tong Li,1,2 Zhan-peng Tang,1,2 Xi-Rui Zhu,1,2 Jing-yi Han,1,2 Hui Tian2 1Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China; 2Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of ChinaCorrespondence: Hui TianDepartment of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of ChinaTel +86 18560080016Email tianhuiql@126.comPurpose: Emerging studies have revealed that platelets are involved in tumor metastasis in lung adenocarcinoma (ADC). The solid pathological subtype of lung ADC is associated with metastasis, recurrence, and poor prognosis. However, there is no study exploring the relationship between platelets and different lung pathological subtypes.Patients and Methods: The association between platelet counts and lymph node metastasis was analyzed in 852 patients with lung ADC who underwent surgery and lymph node dissection. Multivariate logistic analysis was conducted to identify the risk factors of lymph node metastasis. Then, lymph node metastasis and other factors were analyzed to determine their correlation with platelet count and histological subtype.Results: We found that the platelet count was associated with lymph node metastasis (P = 0.01) in multivariable analysis, independent of tumor size, predominant subtype, visceral pleural invasion, and microvessel invasion. In patients with a platelet count ≥ 300 × 109/L, the rate of lymph node metastasis was 38.5%, almost twice as high as that in patients with a platelet count < 300 × 109/L (23.2%). Additionally, elevated platelet counts, even those within the normal range, were significantly associated with a higher rate of lymph node metastasis. The mean platelet count in patients with solid-predominant histology (269.70 ± 69.38 × 109/L) was significantly higher than that in patients with other histologies (P < 0.001).Conclusion: Elevated platelet counts are significantly associated with a higher rate of lymph node metastasis, even if the platelet counts are within the reference range. Platelet counts were significantly higher in patients with solid-predominant histology than in patients with other histologies. In addition, VEGF-C may play an important role in lymphatic metastasis in patients with lung ADC. We hypothesize that antiplatelet therapy may reduce lymph node metastasis in lung ADC patients.Keywords: lung adenocarcinoma, platelets, lymph node, solid-predominant, pathological subtype
first_indexed 2024-12-11T03:30:39Z
format Article
id doaj.art-af59a7166d644a73b218292f766b0f86
institution Directory Open Access Journal
issn 1179-1322
language English
last_indexed 2024-12-11T03:30:39Z
publishDate 2020-10-01
publisher Dove Medical Press
record_format Article
series Cancer Management and Research
spelling doaj.art-af59a7166d644a73b218292f766b0f862022-12-22T01:22:23ZengDove Medical PressCancer Management and Research1179-13222020-10-01Volume 129765977457807Platelet Count is Associated with the Rate of Lymph Node Metastasis in Lung AdenocarcinomaQu CLi TTang ZZhu XRHan JTian HCheng-hao Qu,1,2 Tong Li,1,2 Zhan-peng Tang,1,2 Xi-Rui Zhu,1,2 Jing-yi Han,1,2 Hui Tian2 1Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of China; 2Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of ChinaCorrespondence: Hui TianDepartment of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People’s Republic of ChinaTel +86 18560080016Email tianhuiql@126.comPurpose: Emerging studies have revealed that platelets are involved in tumor metastasis in lung adenocarcinoma (ADC). The solid pathological subtype of lung ADC is associated with metastasis, recurrence, and poor prognosis. However, there is no study exploring the relationship between platelets and different lung pathological subtypes.Patients and Methods: The association between platelet counts and lymph node metastasis was analyzed in 852 patients with lung ADC who underwent surgery and lymph node dissection. Multivariate logistic analysis was conducted to identify the risk factors of lymph node metastasis. Then, lymph node metastasis and other factors were analyzed to determine their correlation with platelet count and histological subtype.Results: We found that the platelet count was associated with lymph node metastasis (P = 0.01) in multivariable analysis, independent of tumor size, predominant subtype, visceral pleural invasion, and microvessel invasion. In patients with a platelet count ≥ 300 × 109/L, the rate of lymph node metastasis was 38.5%, almost twice as high as that in patients with a platelet count < 300 × 109/L (23.2%). Additionally, elevated platelet counts, even those within the normal range, were significantly associated with a higher rate of lymph node metastasis. The mean platelet count in patients with solid-predominant histology (269.70 ± 69.38 × 109/L) was significantly higher than that in patients with other histologies (P < 0.001).Conclusion: Elevated platelet counts are significantly associated with a higher rate of lymph node metastasis, even if the platelet counts are within the reference range. Platelet counts were significantly higher in patients with solid-predominant histology than in patients with other histologies. In addition, VEGF-C may play an important role in lymphatic metastasis in patients with lung ADC. We hypothesize that antiplatelet therapy may reduce lymph node metastasis in lung ADC patients.Keywords: lung adenocarcinoma, platelets, lymph node, solid-predominant, pathological subtypehttps://www.dovepress.com/platelet-count-is-associated-with-the-rate-of-lymph-node-metastasis-in-peer-reviewed-article-CMARlung adenocarcinomaplateletslymph nodesolid-predominantpathological subtype
spellingShingle Qu C
Li T
Tang Z
Zhu XR
Han J
Tian H
Platelet Count is Associated with the Rate of Lymph Node Metastasis in Lung Adenocarcinoma
Cancer Management and Research
lung adenocarcinoma
platelets
lymph node
solid-predominant
pathological subtype
title Platelet Count is Associated with the Rate of Lymph Node Metastasis in Lung Adenocarcinoma
title_full Platelet Count is Associated with the Rate of Lymph Node Metastasis in Lung Adenocarcinoma
title_fullStr Platelet Count is Associated with the Rate of Lymph Node Metastasis in Lung Adenocarcinoma
title_full_unstemmed Platelet Count is Associated with the Rate of Lymph Node Metastasis in Lung Adenocarcinoma
title_short Platelet Count is Associated with the Rate of Lymph Node Metastasis in Lung Adenocarcinoma
title_sort platelet count is associated with the rate of lymph node metastasis in lung adenocarcinoma
topic lung adenocarcinoma
platelets
lymph node
solid-predominant
pathological subtype
url https://www.dovepress.com/platelet-count-is-associated-with-the-rate-of-lymph-node-metastasis-in-peer-reviewed-article-CMAR
work_keys_str_mv AT quc plateletcountisassociatedwiththerateoflymphnodemetastasisinlungadenocarcinoma
AT lit plateletcountisassociatedwiththerateoflymphnodemetastasisinlungadenocarcinoma
AT tangz plateletcountisassociatedwiththerateoflymphnodemetastasisinlungadenocarcinoma
AT zhuxr plateletcountisassociatedwiththerateoflymphnodemetastasisinlungadenocarcinoma
AT hanj plateletcountisassociatedwiththerateoflymphnodemetastasisinlungadenocarcinoma
AT tianh plateletcountisassociatedwiththerateoflymphnodemetastasisinlungadenocarcinoma