Salivary Redox Homeostasis in Human Health and Disease
Homeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/10076 |
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| author | Beáta Čižmárová Vladimíra Tomečková Beáta Hubková Anna Hurajtová Jana Ohlasová Anna Birková |
| author_facet | Beáta Čižmárová Vladimíra Tomečková Beáta Hubková Anna Hurajtová Jana Ohlasová Anna Birková |
| author_sort | Beáta Čižmárová |
| collection | DOAJ |
| description | Homeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathological conditions caused by oxidative stress. In our work, we discuss redox homeostasis and salivary antioxidant activity during healthy periods and in periods of disease: dental carries, oral cavity cancer, periodontal diseases, cardiovascular diseases, diabetes mellitus, systemic sclerosis, and pancreatitis. The composition of saliva reflects dynamic changes in the organism, which makes it an excellent tool for determining clinically valuable biomarkers. The oral cavity and saliva may form the first line of defense against oxidative stress. Analysis of salivary antioxidants may be helpful as a diagnostic, prognostic, and therapeutic marker of not only oral, but also systemic health. |
| first_indexed | 2024-03-10T01:42:33Z |
| format | Article |
| id | doaj.art-af5cf3fa00684283a7f0189c4e3d7541 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:42:33Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-af5cf3fa00684283a7f0189c4e3d75412023-11-23T13:22:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123171007610.3390/ijms231710076Salivary Redox Homeostasis in Human Health and DiseaseBeáta Čižmárová0Vladimíra Tomečková1Beáta Hubková2Anna Hurajtová3Jana Ohlasová4Anna Birková5Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 040 11 Košice, SlovakiaDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 040 11 Košice, SlovakiaDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 040 11 Košice, SlovakiaDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 040 11 Košice, SlovakiaDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 040 11 Košice, SlovakiaDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 040 11 Košice, SlovakiaHomeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathological conditions caused by oxidative stress. In our work, we discuss redox homeostasis and salivary antioxidant activity during healthy periods and in periods of disease: dental carries, oral cavity cancer, periodontal diseases, cardiovascular diseases, diabetes mellitus, systemic sclerosis, and pancreatitis. The composition of saliva reflects dynamic changes in the organism, which makes it an excellent tool for determining clinically valuable biomarkers. The oral cavity and saliva may form the first line of defense against oxidative stress. Analysis of salivary antioxidants may be helpful as a diagnostic, prognostic, and therapeutic marker of not only oral, but also systemic health.https://www.mdpi.com/1422-0067/23/17/10076salivaantioxidantdiseasehomeostasis |
| spellingShingle | Beáta Čižmárová Vladimíra Tomečková Beáta Hubková Anna Hurajtová Jana Ohlasová Anna Birková Salivary Redox Homeostasis in Human Health and Disease International Journal of Molecular Sciences saliva antioxidant disease homeostasis |
| title | Salivary Redox Homeostasis in Human Health and Disease |
| title_full | Salivary Redox Homeostasis in Human Health and Disease |
| title_fullStr | Salivary Redox Homeostasis in Human Health and Disease |
| title_full_unstemmed | Salivary Redox Homeostasis in Human Health and Disease |
| title_short | Salivary Redox Homeostasis in Human Health and Disease |
| title_sort | salivary redox homeostasis in human health and disease |
| topic | saliva antioxidant disease homeostasis |
| url | https://www.mdpi.com/1422-0067/23/17/10076 |
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