The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male Rats
Background and Objectives: Myocardial infarction is one the major causes of mortality in the world. The purpose of this study was to investigate the effects of moderate-intensity interval training on the level of resistance to induced cardiac ischemia in male adult rats. Methods: In this study, 1...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
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Qom University of Medical Sciences
2016-06-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
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| Online Access: | http://journal.muq.ac.ir/browse.php?a_code=A-10-1-520&slc_lang=en&sid=1 |
| _version_ | 1819135672699584512 |
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| author | Hamid Marefati Soheil Aminizadeh Hamid Najafipour Shahriar Dabiri Beydollah Shahouzehi |
| author_facet | Hamid Marefati Soheil Aminizadeh Hamid Najafipour Shahriar Dabiri Beydollah Shahouzehi |
| author_sort | Hamid Marefati |
| collection | DOAJ |
| description | Background and Objectives: Myocardial infarction is one the major causes of mortality in the world. The purpose of this study was to investigate the effects of moderate-intensity interval training on the level of resistance to induced cardiac ischemia in male adult rats.
Methods: In this study, 16 adult male Wistar rats were randomly divided into two groups of 8 mice: Control and moderate-intensity interval training (MIIT). At the end of 16th week of the training, all rats intraperitoneally received isoproterenol (dose, 85mg/kg) for 2 consecutive days, then cardiac function parameters [heart rate, diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular±dp/dt max], Biochemical indicators of tissue damage (heart tissue CTnI and TNF-α) were measured; also, the extent of heart tissue damage was evaluated by histopathological examination. The data were analyzed using nonparametric Mann-Whitney test and independent t-test. The significance level was considered as p≤0.05.
Results: No significant differences were seen between the groups in any of the cardiac function parameters [HR (p<0.130), SBP (p<0.48) and DBP (p<0.72)]. However, other cardiac function parameters including left ventricular±dp/dt max in the exercise group was significantly different from the control group (p<0.01). The heart tissue CTnI in the exercise group was significantly higher than the control group (p<0.009). The heart tissue TNF-α in the exercise group was significantly lower than the control group (p<0.029). Histopathological examinations showed the positive effect of exercise protocol on the reduction of tissue damage in ischemic (p<0.003).
Conclusion: The results showed that moderate-intensity interval training has protective effects against cardiac damage caused by injection of isoproterenol. |
| first_indexed | 2024-12-22T10:22:49Z |
| format | Article |
| id | doaj.art-af5df185ced6463dbc9a096e806a3cab |
| institution | Directory Open Access Journal |
| issn | 1735-7799 2008-1375 |
| language | fas |
| last_indexed | 2024-12-22T10:22:49Z |
| publishDate | 2016-06-01 |
| publisher | Qom University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| spelling | doaj.art-af5df185ced6463dbc9a096e806a3cab2022-12-21T18:29:35ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752016-06-0110419The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male RatsHamid Marefati0Soheil Aminizadeh1Hamid Najafipour2Shahriar Dabiri3Beydollah Shahouzehi4 Kerman University of Medical Sciences Shahid Bahonar University of Kerman Physiology Research Center Kerman University of Medical Sciences, Kerman Kerman University of Medical Sciences, Kerman Background and Objectives: Myocardial infarction is one the major causes of mortality in the world. The purpose of this study was to investigate the effects of moderate-intensity interval training on the level of resistance to induced cardiac ischemia in male adult rats. Methods: In this study, 16 adult male Wistar rats were randomly divided into two groups of 8 mice: Control and moderate-intensity interval training (MIIT). At the end of 16th week of the training, all rats intraperitoneally received isoproterenol (dose, 85mg/kg) for 2 consecutive days, then cardiac function parameters [heart rate, diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular±dp/dt max], Biochemical indicators of tissue damage (heart tissue CTnI and TNF-α) were measured; also, the extent of heart tissue damage was evaluated by histopathological examination. The data were analyzed using nonparametric Mann-Whitney test and independent t-test. The significance level was considered as p≤0.05. Results: No significant differences were seen between the groups in any of the cardiac function parameters [HR (p<0.130), SBP (p<0.48) and DBP (p<0.72)]. However, other cardiac function parameters including left ventricular±dp/dt max in the exercise group was significantly different from the control group (p<0.01). The heart tissue CTnI in the exercise group was significantly higher than the control group (p<0.009). The heart tissue TNF-α in the exercise group was significantly lower than the control group (p<0.029). Histopathological examinations showed the positive effect of exercise protocol on the reduction of tissue damage in ischemic (p<0.003). Conclusion: The results showed that moderate-intensity interval training has protective effects against cardiac damage caused by injection of isoproterenol.http://journal.muq.ac.ir/browse.php?a_code=A-10-1-520&slc_lang=en&sid=1cardiac function test isoproterenol myocardial reperfusion injury exercise. |
| spellingShingle | Hamid Marefati Soheil Aminizadeh Hamid Najafipour Shahriar Dabiri Beydollah Shahouzehi The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male Rats Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum cardiac function test isoproterenol myocardial reperfusion injury exercise. |
| title | The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male Rats |
| title_full | The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male Rats |
| title_fullStr | The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male Rats |
| title_full_unstemmed | The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male Rats |
| title_short | The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male Rats |
| title_sort | effects of moderate intensity interval training on the resistance to induced cardiac ischemia in adult male rats |
| topic | cardiac function test isoproterenol myocardial reperfusion injury exercise. |
| url | http://journal.muq.ac.ir/browse.php?a_code=A-10-1-520&slc_lang=en&sid=1 |
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