Ocena roli badania zjawiska „mimikry naczyniowej” i gęstości mikronaczyń w nowotworach złośliwych jajnika u kobiet
Introduction: Neoplastic cells of various malignant tumours may induce formation of “vascular channels”which are not lined with endothelium. This phenomenon has been called “vasculogenic mimicry”. Objectives: To assess the frequency of vasculogenic mimicry in primary and metastatic malignant ovarian...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2011-04-01
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| Series: | Menopause Review |
| Subjects: | |
| Online Access: | http://www.termedia.pl/Ocena-roli-badania-zjawiska-mimikry-naczyniowej-i-gestosci-mikronaczyn-w-nowotworach-zlosliwych-jajnika-u-kobiet,4,16610,1,0.html |
| _version_ | 1811343827707887616 |
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| author | Jarosław Daniłoś Sylwia Czekierdowska Artur Czekierdowski |
| author_facet | Jarosław Daniłoś Sylwia Czekierdowska Artur Czekierdowski |
| author_sort | Jarosław Daniłoś |
| collection | DOAJ |
| description | Introduction: Neoplastic cells of various malignant tumours may induce formation of “vascular channels”which are not lined with endothelium. This phenomenon has been called “vasculogenic mimicry”. Objectives: To assess the frequency of vasculogenic mimicry in primary and metastatic malignant ovarianmasses in women and to compare it with microvascular density of the most vascularized parts of these tumours. Material and methods: Microvessel density (MVD) and PAS-positive structures representing “vascular channels”were assessed with the use of immunohistochemistry in a group of 66 women operated on because ofmalignant ovarian tumours. CD-34 antigen staining was used for MVD assessment and PAS-positive structureswere identified with modified Schiff’s reaction. Results: Mean age of the study group was 53.9 ±11.7 years (median 53 years, range: 23 to 86 years) and37 women (56.1%) were postmenopausal. There were 37 primary invasive ovarian cancers, 9 cancers of borderlinemalignancy, 10 tumours were metastatic to the ovary and 3 tumours were of non-epithelial origin (two folliculomasand one dysgerminoma). No PAS-positive structures were found in benign (n = 6) or in borderline tumours.Vasculogenic mimicry was found in 47% of primary malignant cancers, 50% of metastatic masses and 100% ofnon-epithelial malignant tumours. PAS-positive channels were most frequently found in high grade (G2 and G3)tumours and in advanced clinical stage cancers (FIGO stage III). Tumours with low MVD had vasculogenic channelspresent in 9 cases and absent in 7 cases. Ovarian malignant tumours with high MVD (> 39 microvessels per HPF)more frequently did not have vascular mimicry present (10 cases with PAS– and 5 cases PAS+). Interestingly, in thevicinity of spots with positive PAS reaction there were only a few CD-34 positive structures identified. Conclusion: Vasculogenic mimicry is a phenomenon that relatively frequently accompanies malignant ovarianneoplasms and can be used as a parameter characterizing the development of alternative vascular-likestructure formation in these tumours. |
| first_indexed | 2024-04-13T19:37:01Z |
| format | Article |
| id | doaj.art-af5ff237485d4dada31a97ee5cca91d1 |
| institution | Directory Open Access Journal |
| issn | 1643-8876 |
| language | English |
| last_indexed | 2024-04-13T19:37:01Z |
| publishDate | 2011-04-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Menopause Review |
| spelling | doaj.art-af5ff237485d4dada31a97ee5cca91d12022-12-22T02:33:00ZengTermedia Publishing HouseMenopause Review1643-88762011-04-0115295101Ocena roli badania zjawiska „mimikry naczyniowej” i gęstości mikronaczyń w nowotworach złośliwych jajnika u kobietJarosław DaniłośSylwia CzekierdowskaArtur CzekierdowskiIntroduction: Neoplastic cells of various malignant tumours may induce formation of “vascular channels”which are not lined with endothelium. This phenomenon has been called “vasculogenic mimicry”. Objectives: To assess the frequency of vasculogenic mimicry in primary and metastatic malignant ovarianmasses in women and to compare it with microvascular density of the most vascularized parts of these tumours. Material and methods: Microvessel density (MVD) and PAS-positive structures representing “vascular channels”were assessed with the use of immunohistochemistry in a group of 66 women operated on because ofmalignant ovarian tumours. CD-34 antigen staining was used for MVD assessment and PAS-positive structureswere identified with modified Schiff’s reaction. Results: Mean age of the study group was 53.9 ±11.7 years (median 53 years, range: 23 to 86 years) and37 women (56.1%) were postmenopausal. There were 37 primary invasive ovarian cancers, 9 cancers of borderlinemalignancy, 10 tumours were metastatic to the ovary and 3 tumours were of non-epithelial origin (two folliculomasand one dysgerminoma). No PAS-positive structures were found in benign (n = 6) or in borderline tumours.Vasculogenic mimicry was found in 47% of primary malignant cancers, 50% of metastatic masses and 100% ofnon-epithelial malignant tumours. PAS-positive channels were most frequently found in high grade (G2 and G3)tumours and in advanced clinical stage cancers (FIGO stage III). Tumours with low MVD had vasculogenic channelspresent in 9 cases and absent in 7 cases. Ovarian malignant tumours with high MVD (> 39 microvessels per HPF)more frequently did not have vascular mimicry present (10 cases with PAS– and 5 cases PAS+). Interestingly, in thevicinity of spots with positive PAS reaction there were only a few CD-34 positive structures identified. Conclusion: Vasculogenic mimicry is a phenomenon that relatively frequently accompanies malignant ovarianneoplasms and can be used as a parameter characterizing the development of alternative vascular-likestructure formation in these tumours.http://www.termedia.pl/Ocena-roli-badania-zjawiska-mimikry-naczyniowej-i-gestosci-mikronaczyn-w-nowotworach-zlosliwych-jajnika-u-kobiet,4,16610,1,0.htmlovarian cancervasculogenic mimicrymicrovessel densityangiogenesis |
| spellingShingle | Jarosław Daniłoś Sylwia Czekierdowska Artur Czekierdowski Ocena roli badania zjawiska „mimikry naczyniowej” i gęstości mikronaczyń w nowotworach złośliwych jajnika u kobiet Menopause Review ovarian cancer vasculogenic mimicry microvessel density angiogenesis |
| title | Ocena roli badania zjawiska „mimikry naczyniowej” i gęstości mikronaczyń w nowotworach złośliwych jajnika u kobiet |
| title_full | Ocena roli badania zjawiska „mimikry naczyniowej” i gęstości mikronaczyń w nowotworach złośliwych jajnika u kobiet |
| title_fullStr | Ocena roli badania zjawiska „mimikry naczyniowej” i gęstości mikronaczyń w nowotworach złośliwych jajnika u kobiet |
| title_full_unstemmed | Ocena roli badania zjawiska „mimikry naczyniowej” i gęstości mikronaczyń w nowotworach złośliwych jajnika u kobiet |
| title_short | Ocena roli badania zjawiska „mimikry naczyniowej” i gęstości mikronaczyń w nowotworach złośliwych jajnika u kobiet |
| title_sort | ocena roli badania zjawiska mimikry naczyniowej i gestosci mikronaczyn w nowotworach zlosliwych jajnika u kobiet |
| topic | ovarian cancer vasculogenic mimicry microvessel density angiogenesis |
| url | http://www.termedia.pl/Ocena-roli-badania-zjawiska-mimikry-naczyniowej-i-gestosci-mikronaczyn-w-nowotworach-zlosliwych-jajnika-u-kobiet,4,16610,1,0.html |
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