Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013–2017: a retrospective study at Thailand’s largest national tertiary referral center
AbstractObjectives To determine the incidence of invasive Group B streptococcal (iGBS) diseases and the factors significantly associated with iGBS mortality in adult patients.Material and methods This retrospective study included adults with a positive culture for GBS isolated from a sterile site at...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
|
| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1930138 |
| _version_ | 1797385717197832192 |
|---|---|
| author | Pakpoom Phoompoung Nantaporn Pirogard Amornrut Leelaporn Nasikarn Angkasekwinai |
| author_facet | Pakpoom Phoompoung Nantaporn Pirogard Amornrut Leelaporn Nasikarn Angkasekwinai |
| author_sort | Pakpoom Phoompoung |
| collection | DOAJ |
| description | AbstractObjectives To determine the incidence of invasive Group B streptococcal (iGBS) diseases and the factors significantly associated with iGBS mortality in adult patients.Material and methods This retrospective study included adults with a positive culture for GBS isolated from a sterile site at Siriraj Hospital – Thailand’s largest tertiary care hospital – during January 2013 to December 2017.Results Of the 224 included patients, 75.9% had bacteraemia. The median age of patients was 63 years (interquartile range [IQR]: 53–73) and 52.7% were female. Among the 80% of all patients with comorbid diseases, diabetes mellitus (38.8%), cancer (18.8%), and heart disease (12.5%) were the most common. Skin and soft tissue infection (30.8%), septic arthritis (21.4%), primary bacteraemia (21.0%), and meningitis (7.1%) were the most common manifestations of iGBS diseases. The overall 30-day mortality was 11%. Patients that died were older and had more chronic kidney disease, bacteraemia, urinary tract infection, pneumonia, and iGBS-related morbidities than survivors. Pneumonia was the only factor independently associated with 30-day mortality with an adjusted odds ratio of 24.96 (95% confidence interval [CI]: 5.95–104.75).Conclusions Invasive GBS is not uncommon in non-pregnant adults, particularly among older adults and those with diabetes. Concomitant bacteraemia was frequently observed in iGBS patients. The overall mortality was low, but significant morbidities were observed.KEY MESSAGESIn our study, iGBS was not uncommon among older adults and those with diabetes.Two-thirds of patients with iGBS had bacteraemia, and the overall 30-day mortality was 11%. |
| first_indexed | 2024-03-08T21:58:17Z |
| format | Article |
| id | doaj.art-af606f41b4f1455e95d83a6826c01fc8 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T21:58:17Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-af606f41b4f1455e95d83a6826c01fc82023-12-19T16:46:27ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-0153171572110.1080/07853890.2021.1930138Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013–2017: a retrospective study at Thailand’s largest national tertiary referral centerPakpoom Phoompoung0Nantaporn Pirogard1Amornrut Leelaporn2Nasikarn Angkasekwinai3Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDivision of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDivision of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandAbstractObjectives To determine the incidence of invasive Group B streptococcal (iGBS) diseases and the factors significantly associated with iGBS mortality in adult patients.Material and methods This retrospective study included adults with a positive culture for GBS isolated from a sterile site at Siriraj Hospital – Thailand’s largest tertiary care hospital – during January 2013 to December 2017.Results Of the 224 included patients, 75.9% had bacteraemia. The median age of patients was 63 years (interquartile range [IQR]: 53–73) and 52.7% were female. Among the 80% of all patients with comorbid diseases, diabetes mellitus (38.8%), cancer (18.8%), and heart disease (12.5%) were the most common. Skin and soft tissue infection (30.8%), septic arthritis (21.4%), primary bacteraemia (21.0%), and meningitis (7.1%) were the most common manifestations of iGBS diseases. The overall 30-day mortality was 11%. Patients that died were older and had more chronic kidney disease, bacteraemia, urinary tract infection, pneumonia, and iGBS-related morbidities than survivors. Pneumonia was the only factor independently associated with 30-day mortality with an adjusted odds ratio of 24.96 (95% confidence interval [CI]: 5.95–104.75).Conclusions Invasive GBS is not uncommon in non-pregnant adults, particularly among older adults and those with diabetes. Concomitant bacteraemia was frequently observed in iGBS patients. The overall mortality was low, but significant morbidities were observed.KEY MESSAGESIn our study, iGBS was not uncommon among older adults and those with diabetes.Two-thirds of patients with iGBS had bacteraemia, and the overall 30-day mortality was 11%.https://www.tandfonline.com/doi/10.1080/07853890.2021.1930138Streptococcus agalactiaeGroup B Streptococcusepidemiologymortality |
| spellingShingle | Pakpoom Phoompoung Nantaporn Pirogard Amornrut Leelaporn Nasikarn Angkasekwinai Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013–2017: a retrospective study at Thailand’s largest national tertiary referral center Annals of Medicine Streptococcus agalactiae Group B Streptococcus epidemiology mortality |
| title | Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013–2017: a retrospective study at Thailand’s largest national tertiary referral center |
| title_full | Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013–2017: a retrospective study at Thailand’s largest national tertiary referral center |
| title_fullStr | Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013–2017: a retrospective study at Thailand’s largest national tertiary referral center |
| title_full_unstemmed | Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013–2017: a retrospective study at Thailand’s largest national tertiary referral center |
| title_short | Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013–2017: a retrospective study at Thailand’s largest national tertiary referral center |
| title_sort | incidence of invasive group b streptococcus igbs infections and the factors associated with igbs mortality in adults during 2013 2017 a retrospective study at thailand s largest national tertiary referral center |
| topic | Streptococcus agalactiae Group B Streptococcus epidemiology mortality |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1930138 |
| work_keys_str_mv | AT pakpoomphoompoung incidenceofinvasivegroupbstreptococcusigbsinfectionsandthefactorsassociatedwithigbsmortalityinadultsduring20132017aretrospectivestudyatthailandslargestnationaltertiaryreferralcenter AT nantapornpirogard incidenceofinvasivegroupbstreptococcusigbsinfectionsandthefactorsassociatedwithigbsmortalityinadultsduring20132017aretrospectivestudyatthailandslargestnationaltertiaryreferralcenter AT amornrutleelaporn incidenceofinvasivegroupbstreptococcusigbsinfectionsandthefactorsassociatedwithigbsmortalityinadultsduring20132017aretrospectivestudyatthailandslargestnationaltertiaryreferralcenter AT nasikarnangkasekwinai incidenceofinvasivegroupbstreptococcusigbsinfectionsandthefactorsassociatedwithigbsmortalityinadultsduring20132017aretrospectivestudyatthailandslargestnationaltertiaryreferralcenter |