Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis
<i>Background and Objectives</i>: The present study demonstrates that apart from the well-known toxicity of liposoluble vitamins, some hydrosoluble vitamins may also exert toxicity; thus, routine supplementation with vitamins or ingestion of fortified foods should not be considered harml...
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MDPI AG
2021-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/11/1204 |
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| author | Mirela Nicolov Mioara Cocora Valentina Buda Corina Danciu Adina Octavia Duse Claudia Watz Florin Borcan |
| author_facet | Mirela Nicolov Mioara Cocora Valentina Buda Corina Danciu Adina Octavia Duse Claudia Watz Florin Borcan |
| author_sort | Mirela Nicolov |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: The present study demonstrates that apart from the well-known toxicity of liposoluble vitamins, some hydrosoluble vitamins may also exert toxicity; thus, routine supplementation with vitamins or ingestion of fortified foods should not be considered harmless. The study addresses the possible correlations between the physico-chemical properties and the side effects of vitamins when taken in high doses or for a too long a period. <i>Materials and Methods</i>: The FAFDrugs4.0 computational tool was used for computational assessment of the ADMET profile of several hydro- and liposoluble vitamins. <i>Results</i>: ADMET analysis revealed the following major data: vitamin B3 and B13 showed reduced structural complexity; thus, a relative toxicological potential may be exerted. Vitamins B1 and B7 were found to have good oral absorption and thus good bioavailability, while Vitamin B3 was found to have decreased oral absorption. In addition, all of the liposoluble vitamins reflected higher complexity, much greater than most of the potentially therapeutically-proven compounds. <i>Conclusions</i>: The present study emphasizes the importance between the physico-chemical properties of vitamins and their possible toxicological impact. |
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| format | Article |
| id | doaj.art-af60b805844d43e2b1d063c04e32839e |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T05:18:06Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-af60b805844d43e2b1d063c04e32839e2023-11-23T00:17:18ZengMDPI AGMedicina1010-660X1648-91442021-11-015711120410.3390/medicina57111204Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET AnalysisMirela Nicolov0Mioara Cocora1Valentina Buda2Corina Danciu3Adina Octavia Duse4Claudia Watz5Florin Borcan6Departament of Pharmaceutical Physics, Faculty of Pharmacy, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timișoara, RomaniaDepartment of Cardiac Surgery, Institute of Cardiovascular Diseases Timișoara, 13A Gh Adam Street, 300310 Timișoara, RomaniaDepartment of Clinical Pharmacy, Communication in Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timișoara, RomaniaResearch Centre for Pharmaco-Toxicological Evaluation, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, RomaniaDepartment of Balneology, Medical Recovery and Rheumatology, Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timișoara, RomaniaDepartament of Pharmaceutical Physics, Faculty of Pharmacy, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timișoara, RomaniaDepartment of Analytical Chemistry, Faculty of Pharmacy, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timișoara, Romania<i>Background and Objectives</i>: The present study demonstrates that apart from the well-known toxicity of liposoluble vitamins, some hydrosoluble vitamins may also exert toxicity; thus, routine supplementation with vitamins or ingestion of fortified foods should not be considered harmless. The study addresses the possible correlations between the physico-chemical properties and the side effects of vitamins when taken in high doses or for a too long a period. <i>Materials and Methods</i>: The FAFDrugs4.0 computational tool was used for computational assessment of the ADMET profile of several hydro- and liposoluble vitamins. <i>Results</i>: ADMET analysis revealed the following major data: vitamin B3 and B13 showed reduced structural complexity; thus, a relative toxicological potential may be exerted. Vitamins B1 and B7 were found to have good oral absorption and thus good bioavailability, while Vitamin B3 was found to have decreased oral absorption. In addition, all of the liposoluble vitamins reflected higher complexity, much greater than most of the potentially therapeutically-proven compounds. <i>Conclusions</i>: The present study emphasizes the importance between the physico-chemical properties of vitamins and their possible toxicological impact.https://www.mdpi.com/1648-9144/57/11/1204water soluble vitaminsfat soluble vitaminsADMET profilebioavailabilitymetabolic stabilitytoxicity |
| spellingShingle | Mirela Nicolov Mioara Cocora Valentina Buda Corina Danciu Adina Octavia Duse Claudia Watz Florin Borcan Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis Medicina water soluble vitamins fat soluble vitamins ADMET profile bioavailability metabolic stability toxicity |
| title | Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis |
| title_full | Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis |
| title_fullStr | Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis |
| title_full_unstemmed | Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis |
| title_short | Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis |
| title_sort | hydrosoluble and liposoluble vitamins new perspectives through admet analysis |
| topic | water soluble vitamins fat soluble vitamins ADMET profile bioavailability metabolic stability toxicity |
| url | https://www.mdpi.com/1648-9144/57/11/1204 |
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