The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder
Abstract INTRODUCTION Emotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients’ descriptions of their cognitive symptoms. METHODS We compared cognitive status and structu...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12450 |
| _version_ | 1827307726151090176 |
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| author | Burak Yulug Sevilay Ayyildiz Dila Sayman Ramazan Karaca Lutfiye Ipek Seyda Cankaya Ali Behram Salar Behcet Ayyildiz Christian Mikuta Nilay Yagci Ece Ozdemir Oktem Ahmet Ozsimsek Halil Aziz Velioglu Lutfu Hanoglu |
| author_facet | Burak Yulug Sevilay Ayyildiz Dila Sayman Ramazan Karaca Lutfiye Ipek Seyda Cankaya Ali Behram Salar Behcet Ayyildiz Christian Mikuta Nilay Yagci Ece Ozdemir Oktem Ahmet Ozsimsek Halil Aziz Velioglu Lutfu Hanoglu |
| author_sort | Burak Yulug |
| collection | DOAJ |
| description | Abstract INTRODUCTION Emotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients’ descriptions of their cognitive symptoms. METHODS We compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as “amnestic” or “nonamnestic,” based on the members’ subjective reports concerning their forgetfulness. We then sought to determine whether these patients would differ in terms of objective neuroimaging and cognitive findings. RESULTS The right pulvinar exhibited altered connectivity in individuals with depression with objective cognitive impairment, a finding which was not apparent in depressive patients with subjective cognitive impairment. DISCUSSION The pulvinar may play a role in depression‐related cognitive impairments. Connectivity network changes may differ between objective and subjective cognitive impairment in depression and may play a role in the increased risk of dementia in patients with depression. |
| first_indexed | 2024-04-24T18:45:35Z |
| format | Article |
| id | doaj.art-af60e8c063bb4666a6215dbb7a7eaeb8 |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-24T18:45:35Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-af60e8c063bb4666a6215dbb7a7eaeb82024-03-27T07:00:57ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372024-01-01101n/an/a10.1002/trc2.12450The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorderBurak Yulug0Sevilay Ayyildiz1Dila Sayman2Ramazan Karaca3Lutfiye Ipek4Seyda Cankaya5Ali Behram Salar6Behcet Ayyildiz7Christian Mikuta8Nilay Yagci9Ece Ozdemir Oktem10Ahmet Ozsimsek11Halil Aziz Velioglu12Lutfu Hanoglu13Department of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya TurkeySchool of Medicine Department of Neuroradiology Technical University of Munich Munich GermanyDepartment of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya TurkeyDepartment of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya TurkeyDepartment of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya TurkeyDepartment of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya TurkeyFunctional Imaging and Cognitive‐Affective Neuroscience Lab (fINCAN) Health Sciences and Technology Research Institute (SABITA) Istanbul Medipol University Istanbul TurkeyAnatomy PhD Program Graduate School of Health Sciences Kocaeli University Istanbul TurkeyTranslational Research Center University Hospital of Psychiatry and Psychotherapy University of Bern Bern SwitzerlandDepartment of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya TurkeyDepartment of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya TurkeyDepartment of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya TurkeyCenter for Psychiatric Neuroscience Feinstein Institute for Medical Research Manhasset New York USADepartment of Neurology and Neuroscience Istanbul Medipol University Istanbul TurkeyAbstract INTRODUCTION Emotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients’ descriptions of their cognitive symptoms. METHODS We compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as “amnestic” or “nonamnestic,” based on the members’ subjective reports concerning their forgetfulness. We then sought to determine whether these patients would differ in terms of objective neuroimaging and cognitive findings. RESULTS The right pulvinar exhibited altered connectivity in individuals with depression with objective cognitive impairment, a finding which was not apparent in depressive patients with subjective cognitive impairment. DISCUSSION The pulvinar may play a role in depression‐related cognitive impairments. Connectivity network changes may differ between objective and subjective cognitive impairment in depression and may play a role in the increased risk of dementia in patients with depression.https://doi.org/10.1002/trc2.12450amnestic depressioncognitiondepressionfunctional magnetic resonance imagingpulvinar |
| spellingShingle | Burak Yulug Sevilay Ayyildiz Dila Sayman Ramazan Karaca Lutfiye Ipek Seyda Cankaya Ali Behram Salar Behcet Ayyildiz Christian Mikuta Nilay Yagci Ece Ozdemir Oktem Ahmet Ozsimsek Halil Aziz Velioglu Lutfu Hanoglu The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder Alzheimer’s & Dementia: Translational Research & Clinical Interventions amnestic depression cognition depression functional magnetic resonance imaging pulvinar |
| title | The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder |
| title_full | The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder |
| title_fullStr | The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder |
| title_full_unstemmed | The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder |
| title_short | The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder |
| title_sort | functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder |
| topic | amnestic depression cognition depression functional magnetic resonance imaging pulvinar |
| url | https://doi.org/10.1002/trc2.12450 |
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