Behavioral and Molecular Effects of Thapsigargin-Induced Brain ER- Stress: Encompassing Inflammation, MAPK, and Insulin Signaling Pathway

Behavioral and Molecular Effects of Thapsigargin-Induced Brain ER- Stress: Encompassing Inflammation, MAPK, and Insulin Signaling Pathway

Accumulation of misfolded proteins, known as endoplasmic reticulum (ER) stress, is known to participate in Alzheimer’s disease (AD). AD is also correlated with impaired central insulin signaling. However, few studies have probed the relationship between memory, central ER stress, inflammation, hippo...

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Bibliographic Details
Main Authors: Sahar Askari, Pegah Javadpour, Fatemeh Sadat Rashidi, Leila Dargahi, Khosrow Kashfi, Rasoul Ghasemi
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Life
Subjects:
Alzheimer’s disease
endoplasmic reticulum stress
apoptosis
inflammation
MAPK
insulin resistance
Online Access:https://www.mdpi.com/2075-1729/12/9/1374

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