Prenatal antibiotic therapy as a risk factor for Neonatal Necrotizing Enterocolitis
The aim of this study was to determine whether there is an association between antenatal antibi-otic exposure and the incidence of necrotizing enterocolitis (NEC) in low birth weight infants.Study design: A retrospective case-control study was conducted on all infants with NEC who were born between...
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2021-07-01
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| Series: | Детские инфекции (Москва) |
| Subjects: | |
| Online Access: | https://detinf.elpub.ru/jour/article/view/595 |
| _version_ | 1797881789682810880 |
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| author | L. G. Bochkova A. S. Eiberman Y. V. Chernenkov O. K. Kirilochev |
| author_facet | L. G. Bochkova A. S. Eiberman Y. V. Chernenkov O. K. Kirilochev |
| author_sort | L. G. Bochkova |
| collection | DOAJ |
| description | The aim of this study was to determine whether there is an association between antenatal antibi-otic exposure and the incidence of necrotizing enterocolitis (NEC) in low birth weight infants.Study design: A retrospective case-control study was conducted on all infants with NEC who were born between 201 0 and 2020. Medical histories of all infants diagnosed with NEC ≥ Bella IIA stage and corresponding controls without NEC were examined. Maternal and newborn char-acteristics were compared using the Cochran-Mantel-Haenszel method, and logistic regression models were constructed to account for bias.Results. Clinical data were analyzed for 97 matched pairs. The adjusted odds ratio (OR) for pre-natal ampicillin exposure was significantly higher for infants who developed NEC (OR 2.3, 95% CI 1.1,4.8, P = 0.003) than for children in the control group. Infants who developed NEC were more likely to have a history of intrauterine exposure to ampicillin in the immediate prenatal period than infants who did not develop NEC. |
| first_indexed | 2024-04-10T03:24:42Z |
| format | Article |
| id | doaj.art-af62361dbf3141e7a1aebf936584e8f8 |
| institution | Directory Open Access Journal |
| issn | 2072-8107 |
| language | Russian |
| last_indexed | 2024-04-10T03:24:42Z |
| publishDate | 2021-07-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj.art-af62361dbf3141e7a1aebf936584e8f82023-03-13T07:28:26ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072021-07-01202333710.22627/2072-8107-2021-20-2-33-37500Prenatal antibiotic therapy as a risk factor for Neonatal Necrotizing EnterocolitisL. G. Bochkova0A. S. Eiberman1Y. V. Chernenkov2O. K. Kirilochev3ФГБОУ ВПО Саратовский государственный медицинский университет им. В.И. Разумовского Министерства здравоохранения Российской ФедерацииФГБОУ ВПО Саратовский государственный медицинский университет им. В.И. Разумовского Министерства здравоохранения Российской ФедерацииФГБОУ ВПО Саратовский государственный медицинский университет им. В.И. Разумовского Министерства здравоохранения Российской ФедерацииАстраханский государственный медицинский университет Министерства здравоохранения Российской ФедерацииThe aim of this study was to determine whether there is an association between antenatal antibi-otic exposure and the incidence of necrotizing enterocolitis (NEC) in low birth weight infants.Study design: A retrospective case-control study was conducted on all infants with NEC who were born between 201 0 and 2020. Medical histories of all infants diagnosed with NEC ≥ Bella IIA stage and corresponding controls without NEC were examined. Maternal and newborn char-acteristics were compared using the Cochran-Mantel-Haenszel method, and logistic regression models were constructed to account for bias.Results. Clinical data were analyzed for 97 matched pairs. The adjusted odds ratio (OR) for pre-natal ampicillin exposure was significantly higher for infants who developed NEC (OR 2.3, 95% CI 1.1,4.8, P = 0.003) than for children in the control group. Infants who developed NEC were more likely to have a history of intrauterine exposure to ampicillin in the immediate prenatal period than infants who did not develop NEC.https://detinf.elpub.ru/jour/article/view/595некротизирующий энтероколитнедоношенные новорожденныеантибиотикотерапияфакторы риска |
| spellingShingle | L. G. Bochkova A. S. Eiberman Y. V. Chernenkov O. K. Kirilochev Prenatal antibiotic therapy as a risk factor for Neonatal Necrotizing Enterocolitis Детские инфекции (Москва) некротизирующий энтероколит недоношенные новорожденные антибиотикотерапия факторы риска |
| title | Prenatal antibiotic therapy as a risk factor for Neonatal Necrotizing Enterocolitis |
| title_full | Prenatal antibiotic therapy as a risk factor for Neonatal Necrotizing Enterocolitis |
| title_fullStr | Prenatal antibiotic therapy as a risk factor for Neonatal Necrotizing Enterocolitis |
| title_full_unstemmed | Prenatal antibiotic therapy as a risk factor for Neonatal Necrotizing Enterocolitis |
| title_short | Prenatal antibiotic therapy as a risk factor for Neonatal Necrotizing Enterocolitis |
| title_sort | prenatal antibiotic therapy as a risk factor for neonatal necrotizing enterocolitis |
| topic | некротизирующий энтероколит недоношенные новорожденные антибиотикотерапия факторы риска |
| url | https://detinf.elpub.ru/jour/article/view/595 |
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