B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential
Autoimmune encephalitis (AE) broadly refers to inflammation of the brain parenchyma mediated by autoimmune mechanisms. In most patients with AE, autoantibodies against neuronal cell surface antigens are produced by B-cells and induce neuronal dysfunction through various mechanisms, ultimately leadin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368275/full |
| _version_ | 1827315495679819776 |
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| author | Haodong Shang Haodong Shang Xinru Shen Xinru Shen Xiaoxiao Yu Xiaoxiao Yu Jing Zhang Jing Zhang Yongliang Jia Yongliang Jia Feng Gao Feng Gao |
| author_facet | Haodong Shang Haodong Shang Xinru Shen Xinru Shen Xiaoxiao Yu Xiaoxiao Yu Jing Zhang Jing Zhang Yongliang Jia Yongliang Jia Feng Gao Feng Gao |
| author_sort | Haodong Shang |
| collection | DOAJ |
| description | Autoimmune encephalitis (AE) broadly refers to inflammation of the brain parenchyma mediated by autoimmune mechanisms. In most patients with AE, autoantibodies against neuronal cell surface antigens are produced by B-cells and induce neuronal dysfunction through various mechanisms, ultimately leading to disease progression. In recent years, B-cell targeted therapies, including monoclonal antibody (mAb) therapy and chimeric antigen receptor T-cell (CAR-T) therapy, have been widely used in autoimmune diseases. These therapies decrease autoantibody levels in patients and have shown favorable results. This review summarizes the mechanisms underlying these two B-cell targeted therapies and discusses their clinical applications and therapeutic potential in AE. Our research provides clinicians with more treatment options for AE patients whose conventional treatments are not effective. |
| first_indexed | 2024-04-24T22:56:17Z |
| format | Article |
| id | doaj.art-af62be1d84f444c793ab28b75c036709 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T22:56:17Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-af62be1d84f444c793ab28b75c0367092024-03-18T04:54:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13682751368275B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potentialHaodong Shang0Haodong Shang1Xinru Shen2Xinru Shen3Xiaoxiao Yu4Xiaoxiao Yu5Jing Zhang6Jing Zhang7Yongliang Jia8Yongliang Jia9Feng Gao10Feng Gao11Department of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, ChinaBGI College, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, ChinaBGI College, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, ChinaBGI College, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, ChinaBGI College, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, ChinaBGI College, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, ChinaBGI College, Zhengzhou University, Zhengzhou, Henan, ChinaAutoimmune encephalitis (AE) broadly refers to inflammation of the brain parenchyma mediated by autoimmune mechanisms. In most patients with AE, autoantibodies against neuronal cell surface antigens are produced by B-cells and induce neuronal dysfunction through various mechanisms, ultimately leading to disease progression. In recent years, B-cell targeted therapies, including monoclonal antibody (mAb) therapy and chimeric antigen receptor T-cell (CAR-T) therapy, have been widely used in autoimmune diseases. These therapies decrease autoantibody levels in patients and have shown favorable results. This review summarizes the mechanisms underlying these two B-cell targeted therapies and discusses their clinical applications and therapeutic potential in AE. Our research provides clinicians with more treatment options for AE patients whose conventional treatments are not effective.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368275/fullautoimmune encephalitisB cell targeted therapiesmonoclonal antibodieschimeric antigen receptorsimmunotherapy |
| spellingShingle | Haodong Shang Haodong Shang Xinru Shen Xinru Shen Xiaoxiao Yu Xiaoxiao Yu Jing Zhang Jing Zhang Yongliang Jia Yongliang Jia Feng Gao Feng Gao B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential Frontiers in Immunology autoimmune encephalitis B cell targeted therapies monoclonal antibodies chimeric antigen receptors immunotherapy |
| title | B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential |
| title_full | B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential |
| title_fullStr | B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential |
| title_full_unstemmed | B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential |
| title_short | B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential |
| title_sort | b cell targeted therapies in autoimmune encephalitis mechanisms clinical applications and therapeutic potential |
| topic | autoimmune encephalitis B cell targeted therapies monoclonal antibodies chimeric antigen receptors immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368275/full |
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