Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study
Previous research indicates that risk for substance use is associated with poor inhibitory control. However, it remains unclear whether at-risk youth follow divergent patterns of inhibitory control development. As part of the longitudinal National Consortium on Adolescent Neurodevelopment and Alcoho...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-04-01
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| Series: | Developmental Cognitive Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929320300190 |
| _version_ | 1818277082585628672 |
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| author | Alina Quach Brenden Tervo-Clemmens William Foran Finnegan J. Calabro Tammy Chung Duncan B. Clark Beatriz Luna |
| author_facet | Alina Quach Brenden Tervo-Clemmens William Foran Finnegan J. Calabro Tammy Chung Duncan B. Clark Beatriz Luna |
| author_sort | Alina Quach |
| collection | DOAJ |
| description | Previous research indicates that risk for substance use is associated with poor inhibitory control. However, it remains unclear whether at-risk youth follow divergent patterns of inhibitory control development. As part of the longitudinal National Consortium on Adolescent Neurodevelopment and Alcohol study, participants (N = 113, baseline age: 12–21) completed a rewarded antisaccade task during fMRI, with up to three time points. We examined whether substance use risk factors, including psychopathology (externalizing, internalizing) and family history of substance use disorder, were associated with developmental differences in inhibitory control performance and BOLD activation. Among the examined substance use risk factors, only externalizing psychopathology exhibited developmental differences in inhibitory control performance, where higher scores were associated with lower correct response rates (p = .013) and shorter latencies (p < .001) in early adolescence that normalized by late adolescence. Neuroimaging results revealed higher externalizing scores were associated with developmentally-stable hypo-activation in the left middle frontal gyrus (p < .05 corrected), but divergent developmental patterns of posterior parietal cortex activation (p < .05 corrected). These findings suggest that early adolescence may be a unique period of substance use vulnerability via cognitive and phenotypic disinhibition. |
| first_indexed | 2024-12-12T22:55:53Z |
| format | Article |
| id | doaj.art-af6390fe1fa547309ab666becab6862d |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-12-12T22:55:53Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-af6390fe1fa547309ab666becab6862d2022-12-22T00:08:57ZengElsevierDevelopmental Cognitive Neuroscience1878-92932020-04-0142Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging studyAlina Quach0Brenden Tervo-Clemmens1William Foran2Finnegan J. Calabro3Tammy Chung4Duncan B. Clark5Beatriz Luna6Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, United States; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, United States; Corresponding author at: Laboratory of Neurocognitive Development, Department of Psychology, Center for Neural Basis of Cognition, University of Pittsburgh, Loeffler Building, 121 Meyran Ave., Pittsburgh, PA, 15213, United States.Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United StatesCenter for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, United States; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, United States; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, United States; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United StatesPrevious research indicates that risk for substance use is associated with poor inhibitory control. However, it remains unclear whether at-risk youth follow divergent patterns of inhibitory control development. As part of the longitudinal National Consortium on Adolescent Neurodevelopment and Alcohol study, participants (N = 113, baseline age: 12–21) completed a rewarded antisaccade task during fMRI, with up to three time points. We examined whether substance use risk factors, including psychopathology (externalizing, internalizing) and family history of substance use disorder, were associated with developmental differences in inhibitory control performance and BOLD activation. Among the examined substance use risk factors, only externalizing psychopathology exhibited developmental differences in inhibitory control performance, where higher scores were associated with lower correct response rates (p = .013) and shorter latencies (p < .001) in early adolescence that normalized by late adolescence. Neuroimaging results revealed higher externalizing scores were associated with developmentally-stable hypo-activation in the left middle frontal gyrus (p < .05 corrected), but divergent developmental patterns of posterior parietal cortex activation (p < .05 corrected). These findings suggest that early adolescence may be a unique period of substance use vulnerability via cognitive and phenotypic disinhibition.http://www.sciencedirect.com/science/article/pii/S1878929320300190AdolescenceSubstance use riskExternalizing psychopathologyInhibitory controlfMRILongitudinal |
| spellingShingle | Alina Quach Brenden Tervo-Clemmens William Foran Finnegan J. Calabro Tammy Chung Duncan B. Clark Beatriz Luna Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study Developmental Cognitive Neuroscience Adolescence Substance use risk Externalizing psychopathology Inhibitory control fMRI Longitudinal |
| title | Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study |
| title_full | Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study |
| title_fullStr | Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study |
| title_full_unstemmed | Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study |
| title_short | Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study |
| title_sort | adolescent development of inhibitory control and substance use vulnerability a longitudinal neuroimaging study |
| topic | Adolescence Substance use risk Externalizing psychopathology Inhibitory control fMRI Longitudinal |
| url | http://www.sciencedirect.com/science/article/pii/S1878929320300190 |
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