The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study
Background: Several vaccines have been approved against COVID-19, and 5 have been used in Indonesia. Due to the decrease in antibody levels 3 to 6 months after the second dose of CoronaVac, healthcare workers received the third booster of mRNA vaccine (mRNA-1273) to increase the antibody level. This...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Infectious Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772431X22000491 |
| _version_ | 1797345868003672064 |
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| author | Allen Widysanto Ignatius Bima Prasetya Tandry Meriyanti Veli Sungono Diane Lukito Setiawan Edy Gunawan Bayu Adiputra Jane Olivia Lorens Theresia Santi Cindy Meidy Leony Pradhana Irawan Yusuf Catherine Gunawan |
| author_facet | Allen Widysanto Ignatius Bima Prasetya Tandry Meriyanti Veli Sungono Diane Lukito Setiawan Edy Gunawan Bayu Adiputra Jane Olivia Lorens Theresia Santi Cindy Meidy Leony Pradhana Irawan Yusuf Catherine Gunawan |
| author_sort | Allen Widysanto |
| collection | DOAJ |
| description | Background: Several vaccines have been approved against COVID-19, and 5 have been used in Indonesia. Due to the decrease in antibody levels 3 to 6 months after the second dose of CoronaVac, healthcare workers received the third booster of mRNA vaccine (mRNA-1273) to increase the antibody level. This study aimed to evaluate the risk factors of anti-S-RBD IgG levels differences in healthcare workers. Methods: This study is a retrospective cohort study of 576 healthcare workers without previous SARS-CoV-2 infection who received 2 doses of CoronaVac and the third dose of mRNA-1273 6 months after the second dose. Blood samples were obtained 2nd, 6th, 12th, and 24th weeks after the second dose of CoronaVac vaccine administration, with mRNA-1273 booster on week 20. Quantitative measurements of IgG antibodies were performed with Elecsys Anti-SARS-CoV-2 S immunoassay. We identify the baseline factors predicting post-vaccination antibody titers using univariate and multivariate linear regression analysis. Results: This study comprised 576 participants aged 32 years old, 72.05% female, and 45.84% from high-risk occupation subgroups. The median antibodies titer level on the 2nd, 6th, 12th, and 24th weeks after the second vaccine dose administration were 40.99 u/mL, 42.01 u/mL, 54.78 u/mL, and 23,225 u/mL. Antibody levels trended highest in female and younger age group (20-29 years old). Conclusions: The third dose of vaccine increased the quantitative SARS-CoV-2 spike IgG antibody titers and eliminated differences in antibodies titer by gender. |
| first_indexed | 2024-03-08T11:24:58Z |
| format | Article |
| id | doaj.art-af6419566456454390f2750f4144d764 |
| institution | Directory Open Access Journal |
| issn | 2772-431X |
| language | English |
| last_indexed | 2024-03-08T11:24:58Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Infectious Medicine |
| spelling | doaj.art-af6419566456454390f2750f4144d7642024-01-26T05:36:05ZengElsevierInfectious Medicine2772-431X2022-12-0114229235The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter studyAllen Widysanto0Ignatius Bima Prasetya1Tandry Meriyanti2Veli Sungono3Diane Lukito Setiawan4Edy Gunawan5Bayu Adiputra6Jane Olivia Lorens7Theresia Santi8Cindy Meidy Leony Pradhana9Irawan Yusuf10Catherine Gunawan11Siloam Hospitals Lippo Village, Banten, Indonesia; Faculty of Medicine, Pelita Harapan University, Banten, Indonesia; Corresponding author.Siloam Hospitals Lippo Village, Banten, Indonesia; Faculty of Medicine, Pelita Harapan University, Banten, IndonesiaSiloam Hospitals Lippo Village, Banten, IndonesiaFaculty of Medicine, Pelita Harapan University, Banten, IndonesiaSiloam Hospitals Surabaya, East Java, IndonesiaClinical Research Department Siloam Hospitals Group, Banten, IndonesiaClinical Research Department Siloam Hospitals Group, Banten, IndonesiaClinical Research Department Siloam Hospitals Group, Banten, IndonesiaSiloam Hospitals Lippo Cikarang, West Java, IndonesiaFaculty of Medicine, Pelita Harapan University, Banten, IndonesiaMochtar Riady Institute for Nanotechnology, Banten, IndonesiaFaculty of Medicine, Pelita Harapan University, Banten, IndonesiaBackground: Several vaccines have been approved against COVID-19, and 5 have been used in Indonesia. Due to the decrease in antibody levels 3 to 6 months after the second dose of CoronaVac, healthcare workers received the third booster of mRNA vaccine (mRNA-1273) to increase the antibody level. This study aimed to evaluate the risk factors of anti-S-RBD IgG levels differences in healthcare workers. Methods: This study is a retrospective cohort study of 576 healthcare workers without previous SARS-CoV-2 infection who received 2 doses of CoronaVac and the third dose of mRNA-1273 6 months after the second dose. Blood samples were obtained 2nd, 6th, 12th, and 24th weeks after the second dose of CoronaVac vaccine administration, with mRNA-1273 booster on week 20. Quantitative measurements of IgG antibodies were performed with Elecsys Anti-SARS-CoV-2 S immunoassay. We identify the baseline factors predicting post-vaccination antibody titers using univariate and multivariate linear regression analysis. Results: This study comprised 576 participants aged 32 years old, 72.05% female, and 45.84% from high-risk occupation subgroups. The median antibodies titer level on the 2nd, 6th, 12th, and 24th weeks after the second vaccine dose administration were 40.99 u/mL, 42.01 u/mL, 54.78 u/mL, and 23,225 u/mL. Antibody levels trended highest in female and younger age group (20-29 years old). Conclusions: The third dose of vaccine increased the quantitative SARS-CoV-2 spike IgG antibody titers and eliminated differences in antibodies titer by gender.http://www.sciencedirect.com/science/article/pii/S2772431X22000491Antibodies titerCOVID-19Immune responseS-RBD IgGVaccine |
| spellingShingle | Allen Widysanto Ignatius Bima Prasetya Tandry Meriyanti Veli Sungono Diane Lukito Setiawan Edy Gunawan Bayu Adiputra Jane Olivia Lorens Theresia Santi Cindy Meidy Leony Pradhana Irawan Yusuf Catherine Gunawan The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study Infectious Medicine Antibodies titer COVID-19 Immune response S-RBD IgG Vaccine |
| title | The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study |
| title_full | The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study |
| title_fullStr | The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study |
| title_full_unstemmed | The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study |
| title_short | The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study |
| title_sort | risk factors of sars cov 2 antibody level differences in healthcare workers post vaccination in siloam hospitals a nationwide multicenter study |
| topic | Antibodies titer COVID-19 Immune response S-RBD IgG Vaccine |
| url | http://www.sciencedirect.com/science/article/pii/S2772431X22000491 |
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