New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation
Natural compounds have been used as wound-healing promoters and are also present in today’s clinical proceedings. In this research, different natural active components such as propolis, Manuka honey, insulin, L-arginine, and <i>Calendula officinalis</i> infusion were included into hyalur...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/8/1291 |
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| author | Oana Maria Ionescu Arn Mignon Andreea Teodora Iacob Natalia Simionescu Luminita Georgeta Confederat Cristina Tuchilus Lenuța Profire |
| author_facet | Oana Maria Ionescu Arn Mignon Andreea Teodora Iacob Natalia Simionescu Luminita Georgeta Confederat Cristina Tuchilus Lenuța Profire |
| author_sort | Oana Maria Ionescu |
| collection | DOAJ |
| description | Natural compounds have been used as wound-healing promoters and are also present in today’s clinical proceedings. In this research, different natural active components such as propolis, Manuka honey, insulin, L-arginine, and <i>Calendula officinalis</i> infusion were included into hyaluronic acid/poly(ethylene)oxide-based electrospun nanofiber membranes to design innovative wound-dressing biomaterials. Morphology and average fiber diameter were analyzed by scanning electron microscopy. Chemical composition was proved by Fourier transform infrared spectroscopy, which indicated successful incorporation of the active components. The nanofiber membranes with propolis and <i>Calendula officinalis</i> showed best antioxidant activity, cytocompatibility, and antimicrobial properties against pathogen strains <i>Staphylococcus aureus, Escherichia coli,</i> and <i>Pseudomonas aeruginosa</i> and had an average diameter of 217 ± 19 nm with smooth surface aspect. Water vapor transmission rate was in agreement with the range suitable for preventing infections or wound dehydration (~5000 g/m<sup>2</sup> 24 h). Therefore, the developed hyaluronic acid/poly(ethylene)oxide nanofibers with additional natural components showed favorable features for clinical use as wound dressings. |
| first_indexed | 2024-03-10T12:18:37Z |
| format | Article |
| id | doaj.art-af64abfe84ad4557a6f0c53416c7cafd |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T12:18:37Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-af64abfe84ad4557a6f0c53416c7cafd2023-11-21T15:42:43ZengMDPI AGPolymers2073-43602021-04-01138129110.3390/polym13081291New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological EvaluationOana Maria Ionescu0Arn Mignon1Andreea Teodora Iacob2Natalia Simionescu3Luminita Georgeta Confederat4Cristina Tuchilus5Lenuța Profire6Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iași, 16 University Street, 700028 Iasi, RomaniaSmart Polymeric Biomaterials, Surface and Interface Engineered Materials, Campus Group T, KU Leuven, Andreas Vesaliusstraat 13, 3000 Leuven, BelgiumDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iași, 16 University Street, 700028 Iasi, RomaniaCentre of Advanced Research in Bionanoconjugates and Biopolymers, Petru Poni Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, RomaniaDepartment of Microbiology, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, RomaniaDepartment of Microbiology, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, RomaniaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iași, 16 University Street, 700028 Iasi, RomaniaNatural compounds have been used as wound-healing promoters and are also present in today’s clinical proceedings. In this research, different natural active components such as propolis, Manuka honey, insulin, L-arginine, and <i>Calendula officinalis</i> infusion were included into hyaluronic acid/poly(ethylene)oxide-based electrospun nanofiber membranes to design innovative wound-dressing biomaterials. Morphology and average fiber diameter were analyzed by scanning electron microscopy. Chemical composition was proved by Fourier transform infrared spectroscopy, which indicated successful incorporation of the active components. The nanofiber membranes with propolis and <i>Calendula officinalis</i> showed best antioxidant activity, cytocompatibility, and antimicrobial properties against pathogen strains <i>Staphylococcus aureus, Escherichia coli,</i> and <i>Pseudomonas aeruginosa</i> and had an average diameter of 217 ± 19 nm with smooth surface aspect. Water vapor transmission rate was in agreement with the range suitable for preventing infections or wound dehydration (~5000 g/m<sup>2</sup> 24 h). Therefore, the developed hyaluronic acid/poly(ethylene)oxide nanofibers with additional natural components showed favorable features for clinical use as wound dressings.https://www.mdpi.com/2073-4360/13/8/1291hyaluronic acidpolyethylene oxideelectrospinningnanofiberswound dressings |
| spellingShingle | Oana Maria Ionescu Arn Mignon Andreea Teodora Iacob Natalia Simionescu Luminita Georgeta Confederat Cristina Tuchilus Lenuța Profire New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation Polymers hyaluronic acid polyethylene oxide electrospinning nanofibers wound dressings |
| title | New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation |
| title_full | New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation |
| title_fullStr | New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation |
| title_full_unstemmed | New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation |
| title_short | New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation |
| title_sort | new hyaluronic acid polyethylene oxide based electrospun nanofibers design characterization and in vitro biological evaluation |
| topic | hyaluronic acid polyethylene oxide electrospinning nanofibers wound dressings |
| url | https://www.mdpi.com/2073-4360/13/8/1291 |
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