Membrane Androgen Receptor Down-Regulates c-Src-Activity and Beta-Catenin Transcription and Triggers GSK-3beta-Phosphorylation in Colon Tumor Cells

Membrane Androgen Receptor Down-Regulates c-Src-Activity and Beta-Catenin Transcription and Triggers GSK-3beta-Phosphorylation in Colon Tumor Cells

Background/Aims: Functional membrane androgen receptors (mARs) have recently been described in colon tumor cells and tissues. Their activation by specific testosterone albumin conjugates (TAC) down-regulates the PI-3K/Akt pro-survival signaling and triggers potent pro-apoptotic responses both, in vi...

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Bibliographic Details
Main Authors: Shuchen Gu, Sabina Honisch, Michalis Kounenidakis, Saad Alkahtani, Saud Alarifi, Konstantinos Alevizopoulos, Christos Stournaras, Florian Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
mARs
c-Src
GSK-3beta
Beta-catenin
Cyclin D1
Actin
Colon tumors
Online Access:http://www.karger.com/Article/FullText/366346

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