Mammographic density and its association with molecular subtype of breast cancer.
Background:Breast cancer is the leading cause of death in women globally. The present study aimed to determine the prevalence of different mammographic density of breast parenchyma along with the association with the molecular subtype of breast cancer.Methodology:The present cross-sectio...
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| Format: | Article |
| Language: | English |
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Advance Educational Institute & Research Centre
2020-12-01
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| Series: | International Journal of Endorsing Health Science Research |
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| Online Access: | http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/533/621 |
| _version_ | 1818873039730769920 |
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| author | Naila Jabeen Binish Rasheed Muhammad Imran Zoobia Zaheeruddin Anila Rahim |
| author_facet | Naila Jabeen Binish Rasheed Muhammad Imran Zoobia Zaheeruddin Anila Rahim |
| author_sort | Naila Jabeen |
| collection | DOAJ |
| description | Background:Breast cancer is the leading cause of death in women globally. The present study aimed to determine the prevalence of different mammographic density of breast parenchyma along with the association with the molecular subtype of breast cancer.Methodology:The present cross-sectional study was conducted among breast cancer females age 40 and above. The study participants' demographic and clinical data, such as age, sex, menstrual status, gravida, parity, and lactation, were collected using a standard questionnaire. The anthropometric parameters were taken by using the standard techniques. Breast physical examination, mammography, and ultrasound were done. The ultrasound did the breast tumor biopsy -guided techniques and histopathology, and immunohistochemistry was used to identify the molecular subtype of breast cancer. The univariate and multivariate statistic was performed on SPSS version 20.0.Results:Most of the patients<50 years were human epidermal growth factor receptor(HER2), estrogen receptor (ER), progesterone receptor (PR)positive, and are overweight too. Similar findings were noted among lactating and multigravida patients. The Grade I tumor and dense breast patients were 100% with HER2 negative and ER, PR positive. Most heterogeneous dense and fibroglandular containing breast patients were ER, PR positive. There is a significant correlation between BMI, microcalcification, and HER2 positive. Most of the triple Negative and Luminal-B were heterogeneous dense.Conclusion:In conclusion, a significant association between the mammographic density parameters and molecular breast cancer subtype, particularly Luminal-A and luminal B, was seen. The ER, PR, and HER-2 have a positive correlation with the physical radiographical and mammodensity parameters. |
| first_indexed | 2024-12-19T12:48:22Z |
| format | Article |
| id | doaj.art-af67fa832d6b45018f7b2db8bbf2eb97 |
| institution | Directory Open Access Journal |
| issn | 2307-3748 2310-3841 |
| language | English |
| last_indexed | 2024-12-19T12:48:22Z |
| publishDate | 2020-12-01 |
| publisher | Advance Educational Institute & Research Centre |
| record_format | Article |
| series | International Journal of Endorsing Health Science Research |
| spelling | doaj.art-af67fa832d6b45018f7b2db8bbf2eb972022-12-21T20:20:40ZengAdvance Educational Institute & Research CentreInternational Journal of Endorsing Health Science Research2307-37482310-38412020-12-018423824810.29052/IJEHSR.v8.i4.2020.238-248Mammographic density and its association with molecular subtype of breast cancer.Naila Jabeen0https://orcid.org/0000-0001-6917-5886Binish Rasheed1https://orcid.org/0000-0002-8894-3729Muhammad Imran2https://orcid.org/0000-0001-5220-496XZoobia Zaheeruddin3https://orcid.org/0000-0002-0770-6896Anila Rahim4https://orcid.org/0000-0002-5913-5044Radiology Department, Dow University of Health Sciences, Karachi-PakistanRadiology Department, Dow University of Health Sciences, Karachi-PakistanDow Institute of Medical Technology,Dow University of Health Sciences, Karachi-Pakistan.Dow Institute of Medical Technology,Dow University of Health Sciences, Karachi-Pakistan.Radiology Department, Dow University of Health Sciences, Karachi-Pakistan.Background:Breast cancer is the leading cause of death in women globally. The present study aimed to determine the prevalence of different mammographic density of breast parenchyma along with the association with the molecular subtype of breast cancer.Methodology:The present cross-sectional study was conducted among breast cancer females age 40 and above. The study participants' demographic and clinical data, such as age, sex, menstrual status, gravida, parity, and lactation, were collected using a standard questionnaire. The anthropometric parameters were taken by using the standard techniques. Breast physical examination, mammography, and ultrasound were done. The ultrasound did the breast tumor biopsy -guided techniques and histopathology, and immunohistochemistry was used to identify the molecular subtype of breast cancer. The univariate and multivariate statistic was performed on SPSS version 20.0.Results:Most of the patients<50 years were human epidermal growth factor receptor(HER2), estrogen receptor (ER), progesterone receptor (PR)positive, and are overweight too. Similar findings were noted among lactating and multigravida patients. The Grade I tumor and dense breast patients were 100% with HER2 negative and ER, PR positive. Most heterogeneous dense and fibroglandular containing breast patients were ER, PR positive. There is a significant correlation between BMI, microcalcification, and HER2 positive. Most of the triple Negative and Luminal-B were heterogeneous dense.Conclusion:In conclusion, a significant association between the mammographic density parameters and molecular breast cancer subtype, particularly Luminal-A and luminal B, was seen. The ER, PR, and HER-2 have a positive correlation with the physical radiographical and mammodensity parameters.http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/533/621breast cancerbreast cancermolecular subtypesbreast parenchymabreast mammographic density |
| spellingShingle | Naila Jabeen Binish Rasheed Muhammad Imran Zoobia Zaheeruddin Anila Rahim Mammographic density and its association with molecular subtype of breast cancer. International Journal of Endorsing Health Science Research breast cancer breast cancermolecular subtypes breast parenchyma breast mammographic density |
| title | Mammographic density and its association with molecular subtype of breast cancer. |
| title_full | Mammographic density and its association with molecular subtype of breast cancer. |
| title_fullStr | Mammographic density and its association with molecular subtype of breast cancer. |
| title_full_unstemmed | Mammographic density and its association with molecular subtype of breast cancer. |
| title_short | Mammographic density and its association with molecular subtype of breast cancer. |
| title_sort | mammographic density and its association with molecular subtype of breast cancer |
| topic | breast cancer breast cancermolecular subtypes breast parenchyma breast mammographic density |
| url | http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/533/621 |
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