Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α
Ca2+-stimulated translocation of cytosolic phospholipase A2α (cPLA2α) to the Golgi induces arachidonic acid production, the rate-limiting step in pro-inflammatory eicosanoid synthesis. Structural insights into the cPLA2α preference for phosphatidylcholine (PC)-enriched membranes have remained elusiv...
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
| Έκδοση: |
eLife Sciences Publications Ltd
2019-05-01
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| Σειρά: | eLife |
| Θέματα: | |
| Διαθέσιμο Online: | https://elifesciences.org/articles/44760 |