Role of microRNA profiling in oral submucous fibrosis pathogenesis and anticarcinogenic action of curcumin in microRNA dysregulation in oral carcinogenesis: A literature update
Oral submucous fibrosis (OSF) is a potentially malignant disorder carrying the highest risk of malignant transformation among the oral premalignant lesions. A wide range of treatment modalities have been proposed for OSF, but none have proved curative or reduced the morbidity significantly. Curcumin...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Dental Sciences |
| Subjects: | |
| Online Access: | http://www.ijds.in/article.asp?issn=0976-4003;year=2019;volume=11;issue=4;spage=175;epage=179;aulast=Acharya |
| _version_ | 1818422154500243456 |
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| author | Shivesh Acharya Shruti Singh Sarabjot Kaur Bhatia |
| author_facet | Shivesh Acharya Shruti Singh Sarabjot Kaur Bhatia |
| author_sort | Shivesh Acharya |
| collection | DOAJ |
| description | Oral submucous fibrosis (OSF) is a potentially malignant disorder carrying the highest risk of malignant transformation among the oral premalignant lesions. A wide range of treatment modalities have been proposed for OSF, but none have proved curative or reduced the morbidity significantly. Curcumin, a hydrophobic polyphenol, derived from turmeric with its wide spectrum of biological functions has been widely accepted as a therapeutic drug in OSF. Recent studies have focused on the regulation of anticancer effect of curcumin through the regulation of microRNA (miRNA). miRNAs are small noncoding RNA molecules that play an important role in cellular growth, differentiation, apoptosis, and immune response, functioning either as tumor suppressors or as tumor promoter. The review attempts to summarize the present understanding of molecular dysregulation of miRNA in OSF pathogenesis and lay new insight on the molecular mechanism of anticarcinogenic effect of curcumin on miRNA involved in oral cancer. |
| first_indexed | 2024-12-14T13:21:45Z |
| format | Article |
| id | doaj.art-af6b32149f6c4b958f873d1b153eb649 |
| institution | Directory Open Access Journal |
| issn | 0976-4003 2231-2293 |
| language | English |
| last_indexed | 2024-12-14T13:21:45Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Sciences |
| spelling | doaj.art-af6b32149f6c4b958f873d1b153eb6492022-12-21T22:59:56ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Sciences0976-40032231-22932019-01-011141751790.4103/IJDS.IJDS_68_19Role of microRNA profiling in oral submucous fibrosis pathogenesis and anticarcinogenic action of curcumin in microRNA dysregulation in oral carcinogenesis: A literature updateShivesh AcharyaShruti SinghSarabjot Kaur BhatiaOral submucous fibrosis (OSF) is a potentially malignant disorder carrying the highest risk of malignant transformation among the oral premalignant lesions. A wide range of treatment modalities have been proposed for OSF, but none have proved curative or reduced the morbidity significantly. Curcumin, a hydrophobic polyphenol, derived from turmeric with its wide spectrum of biological functions has been widely accepted as a therapeutic drug in OSF. Recent studies have focused on the regulation of anticancer effect of curcumin through the regulation of microRNA (miRNA). miRNAs are small noncoding RNA molecules that play an important role in cellular growth, differentiation, apoptosis, and immune response, functioning either as tumor suppressors or as tumor promoter. The review attempts to summarize the present understanding of molecular dysregulation of miRNA in OSF pathogenesis and lay new insight on the molecular mechanism of anticarcinogenic effect of curcumin on miRNA involved in oral cancer.http://www.ijds.in/article.asp?issn=0976-4003;year=2019;volume=11;issue=4;spage=175;epage=179;aulast=AcharyaAreca nutcarcinogenesiscurcuminmicroRNAOSF |
| spellingShingle | Shivesh Acharya Shruti Singh Sarabjot Kaur Bhatia Role of microRNA profiling in oral submucous fibrosis pathogenesis and anticarcinogenic action of curcumin in microRNA dysregulation in oral carcinogenesis: A literature update Indian Journal of Dental Sciences Areca nut carcinogenesis curcumin microRNA OSF |
| title | Role of microRNA profiling in oral submucous fibrosis pathogenesis and anticarcinogenic action of curcumin in microRNA dysregulation in oral carcinogenesis: A literature update |
| title_full | Role of microRNA profiling in oral submucous fibrosis pathogenesis and anticarcinogenic action of curcumin in microRNA dysregulation in oral carcinogenesis: A literature update |
| title_fullStr | Role of microRNA profiling in oral submucous fibrosis pathogenesis and anticarcinogenic action of curcumin in microRNA dysregulation in oral carcinogenesis: A literature update |
| title_full_unstemmed | Role of microRNA profiling in oral submucous fibrosis pathogenesis and anticarcinogenic action of curcumin in microRNA dysregulation in oral carcinogenesis: A literature update |
| title_short | Role of microRNA profiling in oral submucous fibrosis pathogenesis and anticarcinogenic action of curcumin in microRNA dysregulation in oral carcinogenesis: A literature update |
| title_sort | role of microrna profiling in oral submucous fibrosis pathogenesis and anticarcinogenic action of curcumin in microrna dysregulation in oral carcinogenesis a literature update |
| topic | Areca nut carcinogenesis curcumin microRNA OSF |
| url | http://www.ijds.in/article.asp?issn=0976-4003;year=2019;volume=11;issue=4;spage=175;epage=179;aulast=Acharya |
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