Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin
Bigels are biphasic semisolid systems that have been explored as delivery vehicles in the food and pharmaceutical industries. These formulations are highly stable and have a longer shelf-life than emulsions. Similarly, cellulose-based hydrogels are considered to be ideal for these formulations due t...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/8/6/330 |
| _version_ | 1797487255593418752 |
|---|---|
| author | Hamid M. Shaikh Arfat Anis Anesh Manjaly Poulose Niyaz Ahamad Madhar Saeed M. Al-Zahrani |
| author_facet | Hamid M. Shaikh Arfat Anis Anesh Manjaly Poulose Niyaz Ahamad Madhar Saeed M. Al-Zahrani |
| author_sort | Hamid M. Shaikh |
| collection | DOAJ |
| description | Bigels are biphasic semisolid systems that have been explored as delivery vehicles in the food and pharmaceutical industries. These formulations are highly stable and have a longer shelf-life than emulsions. Similarly, cellulose-based hydrogels are considered to be ideal for these formulations due to their biocompatibility and flexibility to mold into various shapes. Accordingly, in the present study, the properties of an optimized guar gum hydrogel and sesame oil/candelilla wax oleogel-based bigel were tailored using date palm-derived cellulose nanocrystals (dp-CNC). These bigels were then explored as carriers for the bioactive molecule moxifloxacin hydrochloride (MH). The preparation of the bigels was achieved by mixing guar gum hydrogel and sesame oil/candelilla wax oleogel. Polarizing microscopy suggested the formation of the hydrogel-in-oleogel type of bigels. An alteration in the dp-CNC content affected the size distribution of the hydrogel phase within the oleogel phase. The colorimetry studies revealed the yellowish-white color of the samples. There were no significant changes in the FTIR functional group positions even after the addition of dp-CNC. In general, the incorporation of dp-CNC resulted in a decrease in the impedance values, except BG3 that had 15 mg dp-CNC in 20 g bigel. The BG3 formulation showed the highest firmness and fluidity. The release of MH from the bigels was quasi-Fickian diffusion mediated. BG3 showed the highest release of the drug. In summary, dp-CNC can be used as a novel reinforcing agent for bigels. |
| first_indexed | 2024-03-09T23:45:03Z |
| format | Article |
| id | doaj.art-af6c61c8ce614a999ba43aa0932672dd |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T23:45:03Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-af6c61c8ce614a999ba43aa0932672dd2023-11-23T16:45:01ZengMDPI AGGels2310-28612022-05-018633010.3390/gels8060330Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for MoxifloxacinHamid M. Shaikh0Arfat Anis1Anesh Manjaly Poulose2Niyaz Ahamad Madhar3Saeed M. Al-Zahrani4SABIC Polymer Research Centre, Department of Chemical Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi ArabiaSABIC Polymer Research Centre, Department of Chemical Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi ArabiaSABIC Polymer Research Centre, Department of Chemical Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi ArabiaDepartment of Physics and Astronomy, College of Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaSABIC Polymer Research Centre, Department of Chemical Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi ArabiaBigels are biphasic semisolid systems that have been explored as delivery vehicles in the food and pharmaceutical industries. These formulations are highly stable and have a longer shelf-life than emulsions. Similarly, cellulose-based hydrogels are considered to be ideal for these formulations due to their biocompatibility and flexibility to mold into various shapes. Accordingly, in the present study, the properties of an optimized guar gum hydrogel and sesame oil/candelilla wax oleogel-based bigel were tailored using date palm-derived cellulose nanocrystals (dp-CNC). These bigels were then explored as carriers for the bioactive molecule moxifloxacin hydrochloride (MH). The preparation of the bigels was achieved by mixing guar gum hydrogel and sesame oil/candelilla wax oleogel. Polarizing microscopy suggested the formation of the hydrogel-in-oleogel type of bigels. An alteration in the dp-CNC content affected the size distribution of the hydrogel phase within the oleogel phase. The colorimetry studies revealed the yellowish-white color of the samples. There were no significant changes in the FTIR functional group positions even after the addition of dp-CNC. In general, the incorporation of dp-CNC resulted in a decrease in the impedance values, except BG3 that had 15 mg dp-CNC in 20 g bigel. The BG3 formulation showed the highest firmness and fluidity. The release of MH from the bigels was quasi-Fickian diffusion mediated. BG3 showed the highest release of the drug. In summary, dp-CNC can be used as a novel reinforcing agent for bigels.https://www.mdpi.com/2310-2861/8/6/330date palm-derived cellulose nanocrystalguar gum hydrogelsesame oilcandelilla waxoleogeldrug delivery |
| spellingShingle | Hamid M. Shaikh Arfat Anis Anesh Manjaly Poulose Niyaz Ahamad Madhar Saeed M. Al-Zahrani Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin Gels date palm-derived cellulose nanocrystal guar gum hydrogel sesame oil candelilla wax oleogel drug delivery |
| title | Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin |
| title_full | Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin |
| title_fullStr | Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin |
| title_full_unstemmed | Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin |
| title_short | Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin |
| title_sort | development of bigels based on date palm derived cellulose nanocrystal reinforced guar gum hydrogel and sesame oil candelilla wax oleogel as delivery vehicles for moxifloxacin |
| topic | date palm-derived cellulose nanocrystal guar gum hydrogel sesame oil candelilla wax oleogel drug delivery |
| url | https://www.mdpi.com/2310-2861/8/6/330 |
| work_keys_str_mv | AT hamidmshaikh developmentofbigelsbasedondatepalmderivedcellulosenanocrystalreinforcedguargumhydrogelandsesameoilcandelillawaxoleogelasdeliveryvehiclesformoxifloxacin AT arfatanis developmentofbigelsbasedondatepalmderivedcellulosenanocrystalreinforcedguargumhydrogelandsesameoilcandelillawaxoleogelasdeliveryvehiclesformoxifloxacin AT aneshmanjalypoulose developmentofbigelsbasedondatepalmderivedcellulosenanocrystalreinforcedguargumhydrogelandsesameoilcandelillawaxoleogelasdeliveryvehiclesformoxifloxacin AT niyazahamadmadhar developmentofbigelsbasedondatepalmderivedcellulosenanocrystalreinforcedguargumhydrogelandsesameoilcandelillawaxoleogelasdeliveryvehiclesformoxifloxacin AT saeedmalzahrani developmentofbigelsbasedondatepalmderivedcellulosenanocrystalreinforcedguargumhydrogelandsesameoilcandelillawaxoleogelasdeliveryvehiclesformoxifloxacin |