Genetic Modifications to Alter Blood Pressure Level
Genetic manipulation is one of the indispensable techniques to examine gene functions both in vitro and in vivo. In particular, cardiovascular phenotypes such as blood pressure cannot be evaluated in vitro system, necessitating the creation of transgenic or gene-targeted knock-out and knock-in exper...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/1855 |
| _version_ | 1797432448997392384 |
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| author | Hiroki Ohara Toru Nabika |
| author_facet | Hiroki Ohara Toru Nabika |
| author_sort | Hiroki Ohara |
| collection | DOAJ |
| description | Genetic manipulation is one of the indispensable techniques to examine gene functions both in vitro and in vivo. In particular, cardiovascular phenotypes such as blood pressure cannot be evaluated in vitro system, necessitating the creation of transgenic or gene-targeted knock-out and knock-in experimental animals to understand the pathophysiological roles of specific genes on the disease conditions. Although genome-wide association studies (GWAS) in various human populations have identified multiple genetic variations associated with increased risk for hypertension and/or its complications, the causal links remain unresolved. Genome-editing technologies can be applied to many different types of cells and organisms for creation of knock-out/knock-in models. In the post-GWAS era, it may be more worthwhile to validate pathophysiological implications of the risk variants and/or candidate genes by creating genome-edited organisms. |
| first_indexed | 2024-03-09T10:00:40Z |
| format | Article |
| id | doaj.art-af6cfbe491d04e3180f94f7201f06896 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:00:40Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-af6cfbe491d04e3180f94f7201f068962023-12-01T23:27:26ZengMDPI AGBiomedicines2227-90592022-08-01108185510.3390/biomedicines10081855Genetic Modifications to Alter Blood Pressure LevelHiroki Ohara0Toru Nabika1Department of Functional Pathology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Functional Pathology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanGenetic manipulation is one of the indispensable techniques to examine gene functions both in vitro and in vivo. In particular, cardiovascular phenotypes such as blood pressure cannot be evaluated in vitro system, necessitating the creation of transgenic or gene-targeted knock-out and knock-in experimental animals to understand the pathophysiological roles of specific genes on the disease conditions. Although genome-wide association studies (GWAS) in various human populations have identified multiple genetic variations associated with increased risk for hypertension and/or its complications, the causal links remain unresolved. Genome-editing technologies can be applied to many different types of cells and organisms for creation of knock-out/knock-in models. In the post-GWAS era, it may be more worthwhile to validate pathophysiological implications of the risk variants and/or candidate genes by creating genome-edited organisms.https://www.mdpi.com/2227-9059/10/8/1855knock-outgenome-editingSHRSHRSPDahl SS |
| spellingShingle | Hiroki Ohara Toru Nabika Genetic Modifications to Alter Blood Pressure Level Biomedicines knock-out genome-editing SHR SHRSP Dahl SS |
| title | Genetic Modifications to Alter Blood Pressure Level |
| title_full | Genetic Modifications to Alter Blood Pressure Level |
| title_fullStr | Genetic Modifications to Alter Blood Pressure Level |
| title_full_unstemmed | Genetic Modifications to Alter Blood Pressure Level |
| title_short | Genetic Modifications to Alter Blood Pressure Level |
| title_sort | genetic modifications to alter blood pressure level |
| topic | knock-out genome-editing SHR SHRSP Dahl SS |
| url | https://www.mdpi.com/2227-9059/10/8/1855 |
| work_keys_str_mv | AT hirokiohara geneticmodificationstoalterbloodpressurelevel AT torunabika geneticmodificationstoalterbloodpressurelevel |