Two Cases of Severe Ulcerative Colitis with Colonic Dilatation Resolved with Tacrolimus Therapy
We report 2 cases of ulcerative colitis (UC) with intestinal tract dilatation treated with tacrolimus. They were 53- and 64-year-old males, who had been admitted to local hospitals for increasing severity of their UC symptoms. Treatment for severe UC was immediately started, but both cases were refr...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2015-07-01
|
| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/438784 |
| _version_ | 1828485658291732480 |
|---|---|
| author | Ryohei Hayashi Yoshitaka Ueno Shinji Tanaka Shintaro Sagami Kenta Nagai Norifumi Shigemoto Shinnosuke Uegami Wataru Shimizu Yusuke Watadani Hiroki Ohge Kazuaki Chayama |
| author_facet | Ryohei Hayashi Yoshitaka Ueno Shinji Tanaka Shintaro Sagami Kenta Nagai Norifumi Shigemoto Shinnosuke Uegami Wataru Shimizu Yusuke Watadani Hiroki Ohge Kazuaki Chayama |
| author_sort | Ryohei Hayashi |
| collection | DOAJ |
| description | We report 2 cases of ulcerative colitis (UC) with intestinal tract dilatation treated with tacrolimus. They were 53- and 64-year-old males, who had been admitted to local hospitals for increasing severity of their UC symptoms. Treatment for severe UC was immediately started, but both cases were refractory to corticosteroid therapy; they were then transferred to our hospital. When they were referred to our hospital, they had frequent bloody diarrhea, fever, severe abdominal pain, and even dilatation of the transverse colon on abdominal X-ray test. They were treated with oral tacrolimus medication, and their symptoms improved immediately. Dilatation of the transverse colon was improved on plain X-ray at 2 weeks after starting therapy, and emergency colectomy could be avoided. These 2 cases may suggest that tacrolimus is effective for UC with colonic dilatation as a rescue therapy. |
| first_indexed | 2024-12-11T09:17:29Z |
| format | Article |
| id | doaj.art-af709ba678af424093d451aefa036dec |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-11T09:17:29Z |
| publishDate | 2015-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-af709ba678af424093d451aefa036dec2022-12-22T01:13:20ZengKarger PublishersCase Reports in Gastroenterology1662-06312015-07-019227227710.1159/000438784438784Two Cases of Severe Ulcerative Colitis with Colonic Dilatation Resolved with Tacrolimus TherapyRyohei HayashiYoshitaka UenoShinji TanakaShintaro SagamiKenta NagaiNorifumi ShigemotoShinnosuke UegamiWataru ShimizuYusuke WatadaniHiroki OhgeKazuaki ChayamaWe report 2 cases of ulcerative colitis (UC) with intestinal tract dilatation treated with tacrolimus. They were 53- and 64-year-old males, who had been admitted to local hospitals for increasing severity of their UC symptoms. Treatment for severe UC was immediately started, but both cases were refractory to corticosteroid therapy; they were then transferred to our hospital. When they were referred to our hospital, they had frequent bloody diarrhea, fever, severe abdominal pain, and even dilatation of the transverse colon on abdominal X-ray test. They were treated with oral tacrolimus medication, and their symptoms improved immediately. Dilatation of the transverse colon was improved on plain X-ray at 2 weeks after starting therapy, and emergency colectomy could be avoided. These 2 cases may suggest that tacrolimus is effective for UC with colonic dilatation as a rescue therapy.http://www.karger.com/Article/FullText/438784Intestinal tract dilatationUlcerative colitisToxic megacolonTacrolimus |
| spellingShingle | Ryohei Hayashi Yoshitaka Ueno Shinji Tanaka Shintaro Sagami Kenta Nagai Norifumi Shigemoto Shinnosuke Uegami Wataru Shimizu Yusuke Watadani Hiroki Ohge Kazuaki Chayama Two Cases of Severe Ulcerative Colitis with Colonic Dilatation Resolved with Tacrolimus Therapy Case Reports in Gastroenterology Intestinal tract dilatation Ulcerative colitis Toxic megacolon Tacrolimus |
| title | Two Cases of Severe Ulcerative Colitis with Colonic Dilatation Resolved with Tacrolimus Therapy |
| title_full | Two Cases of Severe Ulcerative Colitis with Colonic Dilatation Resolved with Tacrolimus Therapy |
| title_fullStr | Two Cases of Severe Ulcerative Colitis with Colonic Dilatation Resolved with Tacrolimus Therapy |
| title_full_unstemmed | Two Cases of Severe Ulcerative Colitis with Colonic Dilatation Resolved with Tacrolimus Therapy |
| title_short | Two Cases of Severe Ulcerative Colitis with Colonic Dilatation Resolved with Tacrolimus Therapy |
| title_sort | two cases of severe ulcerative colitis with colonic dilatation resolved with tacrolimus therapy |
| topic | Intestinal tract dilatation Ulcerative colitis Toxic megacolon Tacrolimus |
| url | http://www.karger.com/Article/FullText/438784 |
| work_keys_str_mv | AT ryoheihayashi twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy AT yoshitakaueno twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy AT shinjitanaka twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy AT shintarosagami twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy AT kentanagai twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy AT norifumishigemoto twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy AT shinnosukeuegami twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy AT watarushimizu twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy AT yusukewatadani twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy AT hirokiohge twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy AT kazuakichayama twocasesofsevereulcerativecolitiswithcolonicdilatationresolvedwithtacrolimustherapy |