Open channel block of Kv1.5 channels by HMQ1611
Kv1.5 channels conduct the ultra-rapid delayed rectifier potassium current (IKur). Pharmacological blockade of human Kv1.5 (hKv1.5) has been regarded as an effective treatment of re-entrant based atrial fibrillation, because Kv1.5 is highly expressed in human cardiac atria but scarcely in ventricles...
Main Authors: | Chao Dong, Jiawei Li, Weiguang Ding, Rika Ueda, Xiaolu Xie, Jie Wu, Hiroshi Matsuura, Minoru Horie |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-09-01
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Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.965086/full |
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