Old and New Blood Markers in Human Colorectal Cancer
Cancer is a predominant cause of mortality all over the world. Lung, prostate, and colorectal cancer are the more frequent in men while breast and colorectal have a high incidence in women. Major progress aside, some cancers are still frequent and one major issue is improvements in detection methods...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/12968 |
| _version_ | 1797468006451773440 |
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| author | Jean-Luc Wautier Marie-Paule Wautier |
| author_facet | Jean-Luc Wautier Marie-Paule Wautier |
| author_sort | Jean-Luc Wautier |
| collection | DOAJ |
| description | Cancer is a predominant cause of mortality all over the world. Lung, prostate, and colorectal cancer are the more frequent in men while breast and colorectal have a high incidence in women. Major progress aside, some cancers are still frequent and one major issue is improvements in detection methods. Imaging techniques have a major role, but inflammatory, tumoral markers and calculated scores may contribute to the assessment of prognosis. The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and carcinoembryonic antigen cell adhesion molecule (CEACAM) have been used for decades and do not have a clear use for diagnosis or prognosis yet. The CEACAM family includes 12 human members, and some of them have a cluster differentiation (CD). CD66 may be an interesting indicator of disease severity. Beside interleukin-6 (IL-6), the high level of which is observed in patients with a high mortality rate, other cytokines IL-17A, IL-22, and transforming growth factor -β (TGF-β) are expressed at the tumor level. The detection of circulating tumor cells has been improved but is still of undetermined value. Circulating tumor DNA (ctDNA) was recently studied in CRC stage II patients and may be helpful for chemotherapy management. |
| first_indexed | 2024-03-09T19:01:51Z |
| format | Article |
| id | doaj.art-af71b9abe72f423ca4420347ab534e08 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:01:51Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-af71b9abe72f423ca4420347ab534e082023-11-24T05:00:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123211296810.3390/ijms232112968Old and New Blood Markers in Human Colorectal CancerJean-Luc Wautier0Marie-Paule Wautier1Faculté de Médecine, Université Denis Diderot Paris, 75013 Paris, FranceFaculté de Médecine, Université Denis Diderot Paris, 75013 Paris, FranceCancer is a predominant cause of mortality all over the world. Lung, prostate, and colorectal cancer are the more frequent in men while breast and colorectal have a high incidence in women. Major progress aside, some cancers are still frequent and one major issue is improvements in detection methods. Imaging techniques have a major role, but inflammatory, tumoral markers and calculated scores may contribute to the assessment of prognosis. The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and carcinoembryonic antigen cell adhesion molecule (CEACAM) have been used for decades and do not have a clear use for diagnosis or prognosis yet. The CEACAM family includes 12 human members, and some of them have a cluster differentiation (CD). CD66 may be an interesting indicator of disease severity. Beside interleukin-6 (IL-6), the high level of which is observed in patients with a high mortality rate, other cytokines IL-17A, IL-22, and transforming growth factor -β (TGF-β) are expressed at the tumor level. The detection of circulating tumor cells has been improved but is still of undetermined value. Circulating tumor DNA (ctDNA) was recently studied in CRC stage II patients and may be helpful for chemotherapy management.https://www.mdpi.com/1422-0067/23/21/12968colorectal cancer (CRC)C-reactive protein (CRP)carcinoembryonic antigen (CEA)CEA cell adhesion molecule (CEACAM)interleukinsmatrix metalloproteinases (MMPs) |
| spellingShingle | Jean-Luc Wautier Marie-Paule Wautier Old and New Blood Markers in Human Colorectal Cancer International Journal of Molecular Sciences colorectal cancer (CRC) C-reactive protein (CRP) carcinoembryonic antigen (CEA) CEA cell adhesion molecule (CEACAM) interleukins matrix metalloproteinases (MMPs) |
| title | Old and New Blood Markers in Human Colorectal Cancer |
| title_full | Old and New Blood Markers in Human Colorectal Cancer |
| title_fullStr | Old and New Blood Markers in Human Colorectal Cancer |
| title_full_unstemmed | Old and New Blood Markers in Human Colorectal Cancer |
| title_short | Old and New Blood Markers in Human Colorectal Cancer |
| title_sort | old and new blood markers in human colorectal cancer |
| topic | colorectal cancer (CRC) C-reactive protein (CRP) carcinoembryonic antigen (CEA) CEA cell adhesion molecule (CEACAM) interleukins matrix metalloproteinases (MMPs) |
| url | https://www.mdpi.com/1422-0067/23/21/12968 |
| work_keys_str_mv | AT jeanlucwautier oldandnewbloodmarkersinhumancolorectalcancer AT mariepaulewautier oldandnewbloodmarkersinhumancolorectalcancer |