KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
The molecular mechanisms of epigenetic regulation in gastric cancer development are not yet well established. In this study, we demonstrated that KMT2A was highly expressed in gastric cancer and associated with poor outcomes of patients and revealed that KMT2A was significantly associated with stemn...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-11-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2023-0764 |
| _version_ | 1797628664837308416 |
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| author | Deng Chongwen Ye Chunhua Liao Xiwang Zhou Fuyin Shi Youxiong Zhong Hong Huang Junbiao |
| author_facet | Deng Chongwen Ye Chunhua Liao Xiwang Zhou Fuyin Shi Youxiong Zhong Hong Huang Junbiao |
| author_sort | Deng Chongwen |
| collection | DOAJ |
| description | The molecular mechanisms of epigenetic regulation in gastric cancer development are not yet well established. In this study, we demonstrated that KMT2A was highly expressed in gastric cancer and associated with poor outcomes of patients and revealed that KMT2A was significantly associated with stemness and increased nuclear β-catenin in gastric cancer. Mechanistically, KMT2A activated the translocation of β-catenin into the nucleus of gastric cancer cells, and then, β-catenin served as a coactivator of KLF11, which promoted the expression of specific gastric cancer stemness-related molecules, including SOX2 and FOXM1. Together, KMT2A is an important epigenetic regulator of gastric cancer stemness, which provides a novel insight to the potential application of targeting against KMT2A in treating gastric cancer. |
| first_indexed | 2024-03-11T10:42:10Z |
| format | Article |
| id | doaj.art-af7288ef320d45fd9d80a7239c792441 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-03-11T10:42:10Z |
| publishDate | 2023-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-af7288ef320d45fd9d80a7239c7924412023-11-14T08:29:50ZengDe GruyterOpen Medicine2391-54632023-11-011811445777110.1515/med-2023-0764KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11Deng Chongwen0Ye Chunhua1Liao Xiwang2Zhou Fuyin3Shi Youxiong4Zhong Hong5Huang Junbiao6Department of General Surgery, Loudi Central Hospital, No. 51, Changqing Middle Street, Loudi, 417000, People’s Republic of ChinaDepartment of General Surgery, Loudi Central Hospital, Loudi, 417000, People’s Republic of ChinaDepartment of General Surgery, Loudi Central Hospital, Loudi, 417000, People’s Republic of ChinaDepartment of General Surgery, Loudi Central Hospital, Loudi, 417000, People’s Republic of ChinaDepartment of General Surgery, Loudi Central Hospital, Loudi, 417000, People’s Republic of ChinaDepartment of General Surgery, Loudi Central Hospital, Loudi, 417000, People’s Republic of ChinaDepartment of General Surgery, Loudi Central Hospital, Loudi, 417000, People’s Republic of ChinaThe molecular mechanisms of epigenetic regulation in gastric cancer development are not yet well established. In this study, we demonstrated that KMT2A was highly expressed in gastric cancer and associated with poor outcomes of patients and revealed that KMT2A was significantly associated with stemness and increased nuclear β-catenin in gastric cancer. Mechanistically, KMT2A activated the translocation of β-catenin into the nucleus of gastric cancer cells, and then, β-catenin served as a coactivator of KLF11, which promoted the expression of specific gastric cancer stemness-related molecules, including SOX2 and FOXM1. Together, KMT2A is an important epigenetic regulator of gastric cancer stemness, which provides a novel insight to the potential application of targeting against KMT2A in treating gastric cancer.https://doi.org/10.1515/med-2023-0764gastric cancerepigenesisstemnesskmt2aβ-cateninklf11 |
| spellingShingle | Deng Chongwen Ye Chunhua Liao Xiwang Zhou Fuyin Shi Youxiong Zhong Hong Huang Junbiao KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11 Open Medicine gastric cancer epigenesis stemness kmt2a β-catenin klf11 |
| title | KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11 |
| title_full | KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11 |
| title_fullStr | KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11 |
| title_full_unstemmed | KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11 |
| title_short | KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11 |
| title_sort | kmt2a maintains stemness of gastric cancer cells through regulating wnt β catenin signaling activated transcriptional factor klf11 |
| topic | gastric cancer epigenesis stemness kmt2a β-catenin klf11 |
| url | https://doi.org/10.1515/med-2023-0764 |
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