MRI to assess response after neoadjuvant chemotherapy in breast cancer subtypes: a systematic review and meta-analysis
Abstract This meta-analysis aimed to estimate and compare sensitivity, specificity, positive- (PPV) and negative predictive value (NPV) of magnetic resonance imaging (MRI) for predicting pathological complete remission (pCR) after neoadjuvant chemotherapy (NAC) in patients with early-stage breast ca...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | npj Breast Cancer |
| Online Access: | https://doi.org/10.1038/s41523-022-00475-1 |
| _version_ | 1797642393770524672 |
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| author | L. M. Janssen B. M. den Dekker K. G. A. Gilhuijs P. J. van Diest E. van der Wall S. G. Elias |
| author_facet | L. M. Janssen B. M. den Dekker K. G. A. Gilhuijs P. J. van Diest E. van der Wall S. G. Elias |
| author_sort | L. M. Janssen |
| collection | DOAJ |
| description | Abstract This meta-analysis aimed to estimate and compare sensitivity, specificity, positive- (PPV) and negative predictive value (NPV) of magnetic resonance imaging (MRI) for predicting pathological complete remission (pCR) after neoadjuvant chemotherapy (NAC) in patients with early-stage breast cancer. We stratified for molecular subtype by immunohistochemistry (IHC) and explored the impact of other factors. Two researchers systematically searched PUBMED and EMBASE to select relevant studies and extract data. For meta-analysis of sensitivity and specificity, we used bivariate random-effects models. Twenty-six included studies contained 4497 patients. There was a significant impact of IHC subtype on post-NAC MRI accuracy (p = 0.0082) for pCR. The pooled sensitivity was 0.67 [95% CI 0.58–0.74] for the HR−/HER2−, 0.65 [95% CI 0.56–0.73] for the HR−/HER2+, 0.55 [95% CI 0.45–0.64] for the HR+/HER2− and 0.60 [95% CI 0.50–0.70] for the HR+/HER2+ subtype. The pooled specificity was 0.85 [95% CI 0.81–0.88] for the HR−/HER2−, 0.81 [95% CI 0.74–0.86] for the HR−/HER2+, 0.88[95% CI 0.84–0.91] for the HR+/HER2− and 0.74 [95% CI 0.63–0.83] for the HR+/HER2+ subtype. The PPV was highest in the HR-/HER2- subtype and lowest in the HR+/HER2− subtype. MRI field strength of 3.0 T was associated with a higher sensitivity compared to 1.5 T (p = 0.00063). The accuracy of MRI for predicting pCR depends on molecular subtype, which should be taken into account in clinical practice. Higher MRI field strength positively impacts accuracy. When intervention trials based on MRI response evaluation are designed, the impact of IHC subtype and field strength on MR accuracy should be considered. |
| first_indexed | 2024-03-11T13:59:36Z |
| format | Article |
| id | doaj.art-af750050f9b648d6856c3557a9eda8c7 |
| institution | Directory Open Access Journal |
| issn | 2374-4677 |
| language | English |
| last_indexed | 2024-03-11T13:59:36Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Breast Cancer |
| spelling | doaj.art-af750050f9b648d6856c3557a9eda8c72023-11-02T05:20:50ZengNature Portfolionpj Breast Cancer2374-46772022-09-01811710.1038/s41523-022-00475-1MRI to assess response after neoadjuvant chemotherapy in breast cancer subtypes: a systematic review and meta-analysisL. M. Janssen0B. M. den Dekker1K. G. A. Gilhuijs2P. J. van Diest3E. van der Wall4S. G. Elias5Image Sciences Institute, University Medical Center Utrecht, Utrecht UniversityDepartment of Radiology, University Medical Center Utrecht, Utrecht UniversityImage Sciences Institute, University Medical Center Utrecht, Utrecht UniversityDepartment of Pathology, University Medical Centre Utrecht, Utrecht UniversityDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht UniversityJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityAbstract This meta-analysis aimed to estimate and compare sensitivity, specificity, positive- (PPV) and negative predictive value (NPV) of magnetic resonance imaging (MRI) for predicting pathological complete remission (pCR) after neoadjuvant chemotherapy (NAC) in patients with early-stage breast cancer. We stratified for molecular subtype by immunohistochemistry (IHC) and explored the impact of other factors. Two researchers systematically searched PUBMED and EMBASE to select relevant studies and extract data. For meta-analysis of sensitivity and specificity, we used bivariate random-effects models. Twenty-six included studies contained 4497 patients. There was a significant impact of IHC subtype on post-NAC MRI accuracy (p = 0.0082) for pCR. The pooled sensitivity was 0.67 [95% CI 0.58–0.74] for the HR−/HER2−, 0.65 [95% CI 0.56–0.73] for the HR−/HER2+, 0.55 [95% CI 0.45–0.64] for the HR+/HER2− and 0.60 [95% CI 0.50–0.70] for the HR+/HER2+ subtype. The pooled specificity was 0.85 [95% CI 0.81–0.88] for the HR−/HER2−, 0.81 [95% CI 0.74–0.86] for the HR−/HER2+, 0.88[95% CI 0.84–0.91] for the HR+/HER2− and 0.74 [95% CI 0.63–0.83] for the HR+/HER2+ subtype. The PPV was highest in the HR-/HER2- subtype and lowest in the HR+/HER2− subtype. MRI field strength of 3.0 T was associated with a higher sensitivity compared to 1.5 T (p = 0.00063). The accuracy of MRI for predicting pCR depends on molecular subtype, which should be taken into account in clinical practice. Higher MRI field strength positively impacts accuracy. When intervention trials based on MRI response evaluation are designed, the impact of IHC subtype and field strength on MR accuracy should be considered.https://doi.org/10.1038/s41523-022-00475-1 |
| spellingShingle | L. M. Janssen B. M. den Dekker K. G. A. Gilhuijs P. J. van Diest E. van der Wall S. G. Elias MRI to assess response after neoadjuvant chemotherapy in breast cancer subtypes: a systematic review and meta-analysis npj Breast Cancer |
| title | MRI to assess response after neoadjuvant chemotherapy in breast cancer subtypes: a systematic review and meta-analysis |
| title_full | MRI to assess response after neoadjuvant chemotherapy in breast cancer subtypes: a systematic review and meta-analysis |
| title_fullStr | MRI to assess response after neoadjuvant chemotherapy in breast cancer subtypes: a systematic review and meta-analysis |
| title_full_unstemmed | MRI to assess response after neoadjuvant chemotherapy in breast cancer subtypes: a systematic review and meta-analysis |
| title_short | MRI to assess response after neoadjuvant chemotherapy in breast cancer subtypes: a systematic review and meta-analysis |
| title_sort | mri to assess response after neoadjuvant chemotherapy in breast cancer subtypes a systematic review and meta analysis |
| url | https://doi.org/10.1038/s41523-022-00475-1 |
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