Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP
Studying the physiological confirmation of amyloid β (Aβ) and amyloid precursor protein (APP) often uses techniques that could disrupt their conformation. Here, the authors use non-destructive microscopy approaches to study the confirmation of Aβ and APP in mouse models of Alzheimer’s disease.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14726 |
| _version_ | 1819195758467874816 |
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| author | O. Klementieva K. Willén I. Martinsson B. Israelsson A. Engdahl J. Cladera P. Uvdal G. K. Gouras |
| author_facet | O. Klementieva K. Willén I. Martinsson B. Israelsson A. Engdahl J. Cladera P. Uvdal G. K. Gouras |
| author_sort | O. Klementieva |
| collection | DOAJ |
| description | Studying the physiological confirmation of amyloid β (Aβ) and amyloid precursor protein (APP) often uses techniques that could disrupt their conformation. Here, the authors use non-destructive microscopy approaches to study the confirmation of Aβ and APP in mouse models of Alzheimer’s disease. |
| first_indexed | 2024-12-23T02:17:51Z |
| format | Article |
| id | doaj.art-af765fa52d0140b79804721f5a08b6fa |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:17:51Z |
| publishDate | 2017-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-af765fa52d0140b79804721f5a08b6fa2022-12-21T18:03:37ZengNature PortfolioNature Communications2041-17232017-03-01811910.1038/ncomms14726Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APPO. Klementieva0K. Willén1I. Martinsson2B. Israelsson3A. Engdahl4J. Cladera5P. Uvdal6G. K. Gouras7Department of Experimental Medical Science, Experimental Dementia Research Unit, Lund UniversityDepartment of Experimental Medical Science, Experimental Dementia Research Unit, Lund UniversityDepartment of Experimental Medical Science, Experimental Dementia Research Unit, Lund UniversityDepartment of Experimental Medical Science, Experimental Dementia Research Unit, Lund UniversityMAX IV Laboratory, Lund UniversityDepartment of Biochemistry and Molecular Biology, Universitat Autònoma de BarcelonaMAX IV Laboratory, Lund UniversityDepartment of Experimental Medical Science, Experimental Dementia Research Unit, Lund UniversityStudying the physiological confirmation of amyloid β (Aβ) and amyloid precursor protein (APP) often uses techniques that could disrupt their conformation. Here, the authors use non-destructive microscopy approaches to study the confirmation of Aβ and APP in mouse models of Alzheimer’s disease.https://doi.org/10.1038/ncomms14726 |
| spellingShingle | O. Klementieva K. Willén I. Martinsson B. Israelsson A. Engdahl J. Cladera P. Uvdal G. K. Gouras Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP Nature Communications |
| title | Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP |
| title_full | Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP |
| title_fullStr | Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP |
| title_full_unstemmed | Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP |
| title_short | Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP |
| title_sort | pre plaque conformational changes in alzheimer s disease linked aβ and app |
| url | https://doi.org/10.1038/ncomms14726 |
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