Effect of continuous intravenous injection of different doses of dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery
Objective To analyze the effect of continuous intravenous injection of different doses on dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery. Methods A total of 120 patients with thyroidectomy admitted to the First Affiliated Hospital of Army Medic...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2020-08-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a191357.pdf |
| _version_ | 1797365739172134912 |
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| author | WU Yan, CHEN Yang, LYU Rui, ZHANG Ming, LU Kai-zhi, SHEN Jiang-hua |
| author_facet | WU Yan, CHEN Yang, LYU Rui, ZHANG Ming, LU Kai-zhi, SHEN Jiang-hua |
| author_sort | WU Yan, CHEN Yang, LYU Rui, ZHANG Ming, LU Kai-zhi, SHEN Jiang-hua |
| collection | DOAJ |
| description | Objective To analyze the effect of continuous intravenous injection of different doses on dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery. Methods A total of 120 patients with thyroidectomy admitted to the First Affiliated Hospital of Army Medical University from November 2017 to November 2019 were randomly divided into a control group (60 patients) with continuous intravenous injection of 0.8 μg/kg dexmedetomidine. The observation group (60 patients) were given 0.4 μg/kg dexmedetomidine. The SBP, DBP, HR, Ramsay, VAS score, arousal index and adverse reactions were compared between the two groups at different time periods. Results The scores of SBP, DBP, HR and VAS, the incidence of nausea, vomiting, laryngospasm and choking cough in the observation group were not different from those in the control group at different time periods. The Ramsay scores of the observation group at different time periods were significantly lower than those of the control group(P＜0.05). The time of eye opening, extubation and directional force recovery in the observation group were significantly shorter than those in the control group (P＜0.05). The incidence of bradycardia in the observation group was 1.67%, which was significantly lower than that in the control group(6.68%) (P＜0.05). Conclusions 0.4 and 0.8 μg/kg dexmedetomidine can maintain hemodynamic stability in the recovery period of general anesthesia in patients undergoing thyroid surgery, but 0.8 μg/kg has more sedative effect and higher incidence of bradycardia, so it is recommended to use 0.4 μg/kg dexmedetomidine. |
| first_indexed | 2024-03-08T16:53:15Z |
| format | Article |
| id | doaj.art-af774cbaaf89427599264d9044b0438e |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:53:15Z |
| publishDate | 2020-08-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-af774cbaaf89427599264d9044b0438e2024-01-05T03:16:59ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252020-08-0140810371040Effect of continuous intravenous injection of different doses of dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgeryWU Yan, CHEN Yang, LYU Rui, ZHANG Ming, LU Kai-zhi, SHEN Jiang-hua0Department of Anesthesiology, the First Affiliated Hospital of Army Medical University,Chongqing 400038,ChinaObjective To analyze the effect of continuous intravenous injection of different doses on dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery. Methods A total of 120 patients with thyroidectomy admitted to the First Affiliated Hospital of Army Medical University from November 2017 to November 2019 were randomly divided into a control group (60 patients) with continuous intravenous injection of 0.8 μg/kg dexmedetomidine. The observation group (60 patients) were given 0.4 μg/kg dexmedetomidine. The SBP, DBP, HR, Ramsay, VAS score, arousal index and adverse reactions were compared between the two groups at different time periods. Results The scores of SBP, DBP, HR and VAS, the incidence of nausea, vomiting, laryngospasm and choking cough in the observation group were not different from those in the control group at different time periods. The Ramsay scores of the observation group at different time periods were significantly lower than those of the control group(P＜0.05). The time of eye opening, extubation and directional force recovery in the observation group were significantly shorter than those in the control group (P＜0.05). The incidence of bradycardia in the observation group was 1.67%, which was significantly lower than that in the control group(6.68%) (P＜0.05). Conclusions 0.4 and 0.8 μg/kg dexmedetomidine can maintain hemodynamic stability in the recovery period of general anesthesia in patients undergoing thyroid surgery, but 0.8 μg/kg has more sedative effect and higher incidence of bradycardia, so it is recommended to use 0.4 μg/kg dexmedetomidine.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a191357.pdfdifferent doses|dexmedetomidine|continuous intravenous injection|thyroid surgery|recovery period of general anesthesia |
| spellingShingle | WU Yan, CHEN Yang, LYU Rui, ZHANG Ming, LU Kai-zhi, SHEN Jiang-hua Effect of continuous intravenous injection of different doses of dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery Jichu yixue yu linchuang different doses|dexmedetomidine|continuous intravenous injection|thyroid surgery|recovery period of general anesthesia |
| title | Effect of continuous intravenous injection of different doses of dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery |
| title_full | Effect of continuous intravenous injection of different doses of dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery |
| title_fullStr | Effect of continuous intravenous injection of different doses of dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery |
| title_full_unstemmed | Effect of continuous intravenous injection of different doses of dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery |
| title_short | Effect of continuous intravenous injection of different doses of dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery |
| title_sort | effect of continuous intravenous injection of different doses of dexmedetomidine on the recovery period of general anesthesia in patients undergoing thyroid surgery |
| topic | different doses|dexmedetomidine|continuous intravenous injection|thyroid surgery|recovery period of general anesthesia |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a191357.pdf |
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