Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo

Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo

Yuan-Yuan Zhao,1,* Ying Tian,1,* Jing Zhang,2,* Fei Xu,1 Yun-Peng Yang,1 Yan Huang,1 Hong-Yun Zhao,3 Jian-Wei Zhang,4 Cong Xue,1 Michael H Lam,5 Li Yan,5 Zhi-Huang Hu,1 Xiao-Xiao Dinglin,6 Li Zhang1,3 1Department of Medical Oncology, Sun Yat-Sen University Cancer Center,...

Full description

Bibliographic Details
Main Authors:	Zhao YY, Tian Y, Zhang J, Xu F, Yang YP, Huang Y, Zhao HY, Zhang JW, Xue C, Lam MH, Yan L, Hu ZH, Dinglin XX, Zhang L
Format:	Article
Language:	English
Published:	Dove Medical Press 2014-10-01
Series:	Drug Design, Development and Therapy
Online Access:	http://www.dovepress.com/effects-of-an-oral-allosteric-akt-inhibitor-mk-2206-on-human-nasophary-peer-reviewed-article-DDDT

Similar Items

A phase II study of MK-2206, an AKT inhibitor, in uterine serous carcinoma
by: Elizabeth H. Stover, et al.
Published: (2022-04-01)

In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma
by: Xue C, et al.
Published: (2016-03-01)

Radiation therapy-induced reactive oxygen species specifically eliminates CD19+ IgA+ B cells in nasopharyngeal carcinoma
by: Li W, et al.
Published: (2019-07-01)

MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro
by: Meiling Chen, et al.
Published: (2022-11-01)

MK2206 Enhances Cisplatin-Induced Cytotoxicity and Apoptosis in Testicular Cancer Through Akt Signaling Pathway Inhibition
by: Dingqi Sun, et al.
Published: (2020-07-01)

Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold
by: Zhang Y, et al.
Published: (2015-10-01)

The N6-Methyladenosine (m6A) Methylation Gene YTHDF1 Reveals a Potential Diagnostic Role for Gastric Cancer
by: Liu T, et al.
Published: (2020-11-01)

Patient-reported treatment satisfaction and choice of dosing frequency with biologic treatment for moderate to severe plaque psoriasis
by: Zhang M, et al.
Published: (2015-06-01)

Association analysis of polymorphisms in STARD6 and near ECHDC3 in Alzheimer’s disease patients carrying the APOE ε4 Allele
by: Yin J, et al.
Published: (2019-01-01)

Medical cannabis ‒ the Canadian perspective 
by: Ko GD, et al.
Published: (2016-09-01)

The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells
by: Hai-Ling Gao, et al.
Published: (2023-07-01)

Chitosan-decorated selenium nanoparticles as protein carriers to improve the in vivo half-life of the peptide therapeutic BAY 55-9837 for type 2 diabetes mellitus
by: Rao L, et al.
Published: (2014-10-01)

Injectable long-acting systems for Radix Ophiopogonis polysaccharide based on mono-PEGylation and in situ formation of a PLGA depot
by: Shi XL, et al.
Published: (2014-11-01)

Cervical Ossification of Ligamentum Flavum: Elaborating an Underappreciated but Occasional Contributor to Myeloradiculopathy in Aging Population Based on Synthesis of Individual Participant Data
by: Zhang B, et al.
Published: (2021-05-01)

Bioethics in Correlation with the Principle of Human Dignity
by: Sanita Osipova
Published: (2020-10-01)

Emergence of Almost Identical F36:A-:B32 Plasmids Carrying blaNDM-5 and qepA in Escherichia coli from Both Pakistan and Canada
by: Baloch Z, et al.
Published: (2019-12-01)

Use of electrical impedance spectroscopy to detect malignant and potentially malignant oral lesions
by: Murdoch C, et al.
Published: (2014-09-01)

Relationship Between Proteinase with a Disintegrin and a Metalloproteinase Domain-9 (ADAM9), Inflammation, Airway Remodeling, and Emphysema in COPD Patients
by: Cui L, et al.
Published: (2020-12-01)

An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin
by: Galdiero E, et al.
Published: (2016-08-01)

Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity
by: Lim JP, et al.
Published: (2015-03-01)

Soluble receptor for advanced glycation end products in critically ill patients and its associations with other clinical markers and 28-day mortality
by: Cheng YZ, et al.
Published: (2014-11-01)

Optimal management of pulmonary arterial hypertension: prognostic indicators to determine treatment course
by: Baldi F, et al.
Published: (2014-10-01)

Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses
by: Nagahara Y, et al.
Published: (2015-06-01)

MicroRNAs and Exosomal microRNAs May Be Possible Targets to Investigate in Gestational Diabetes Mellitus
by: Yang X, et al.
Published: (2022-02-01)

The analyses of risk factors for COPD in the Li ethnic group in Hainan, People’s Republic of China
by: Ding YP, et al.
Published: (2015-11-01)

Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?
by: Asaoka D, et al.
Published: (2015-03-01)

Downregulation of ATXN3 Enhances the Sensitivity to AKT Inhibitors (Perifosine or MK-2206), but Decreases the Sensitivity to Chemotherapeutic Drugs (Etoposide or Cisplatin) in Neuroblastoma Cells
by: Baocheng Gong, et al.
Published: (2021-07-01)

Shen-Qi-Jie-Yu-Fang has antidepressant effects in a rodent model of postpartum depression by regulating the immune organs and subsets of T lymphocytes
by: Qu M, et al.
Published: (2015-06-01)

Combined Application of Pan-AKT Inhibitor MK-2206 and BCL-2 Antagonist Venetoclax in B-Cell Precursor Acute Lymphoblastic Leukemia
by: Anna Richter, et al.
Published: (2021-03-01)

The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner.
by: Jieru Meng, et al.
Published: (2013-01-01)

Upconversion nanoparticles conjugated with curcumin as a photosensitizer to inhibit methicillin-resistant Staphylococcus aureus in lung under near infrared light
by: Ye Y, et al.
Published: (2014-11-01)

Association of metabotropic glutamate receptor 3 gene polymorphisms with schizophrenia risk: evidence from a meta-analysis
by: Yang X, et al.
Published: (2015-03-01)

Aminaphtone in the control of gingival bleeding in children
by: Pereira de Godoy JM, et al.
Published: (2014-09-01)

Nordisk barnelitteratur  ̶  et nytt kunstforskningsspørsmål?
by: Kristin Ørjasæter, et al.
Published: (2013-05-01)

Comparison of blood gas analysis parameters, biochemical tests and hematological parameters in geriatric patients admitted to the emergency department
by: Ayşegül Bilge, et al.
Published: (2023-04-01)

Incident Management for Explainable and Automated Root Cause Analysis in Cloud Data Centers&nbsp;&nbsp;&nbsp;&nbsp;
by: Arnak Poghosyan, et al.
Published: (2021-11-01)

Knockdown of USP8 Inhibits the Growth of Lung Cancer Cells
by: Rong Z, et al.
Published: (2020-12-01)

Influence of sex on outcomes after percutaneous coronary intervention in patients over 75 years of age with coronary heart disease
by: Liu Y, et al.
Published: (2014-10-01)

Corrigendum: Downregulation of ATXN3 enhances the sensitivity to AKT inhibitors (Perifosine or MK-2206), but decreases the sensitivity to chemotherapeutic drugs (etoposide or cisplatin) in neuroblastoma cells
by: Baocheng Gong, et al.
Published: (2022-08-01)

Operative management of intracerebral hemorrhage: 3 year experience in multidisciplinary city hospital
by: Iroda Mammadinova, et al.
Published: (2022-10-01)