Field evaluation of a push-pull system to reduce malaria transmission.
Malaria continues to place a disease burden on millions of people throughout the tropics, especially in sub-Saharan Africa. Although efforts to control mosquito populations and reduce human-vector contact, such as long-lasting insecticidal nets and indoor residual spraying, have led to significant d...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0123415 |
| _version_ | 1818682572928974848 |
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| author | David J Menger Philemon Omusula Maarten Holdinga Tobias Homan Ana S Carreira Patrice Vandendaele Jean-Luc Derycke Collins K Mweresa Wolfgang Richard Mukabana Joop J A van Loon Willem Takken |
| author_facet | David J Menger Philemon Omusula Maarten Holdinga Tobias Homan Ana S Carreira Patrice Vandendaele Jean-Luc Derycke Collins K Mweresa Wolfgang Richard Mukabana Joop J A van Loon Willem Takken |
| author_sort | David J Menger |
| collection | DOAJ |
| description | Malaria continues to place a disease burden on millions of people throughout the tropics, especially in sub-Saharan Africa. Although efforts to control mosquito populations and reduce human-vector contact, such as long-lasting insecticidal nets and indoor residual spraying, have led to significant decreases in malaria incidence, further progress is now threatened by the widespread development of physiological and behavioural insecticide-resistance as well as changes in the composition of vector populations. A mosquito-directed push-pull system based on the simultaneous use of attractive and repellent volatiles offers a complementary tool to existing vector-control methods. In this study, the combination of a trap baited with a five-compound attractant and a strip of net-fabric impregnated with micro-encapsulated repellent and placed in the eaves of houses, was tested in a malaria-endemic village in western Kenya. Using the repellent delta-undecalactone, mosquito house entry was reduced by more than 50%, while the traps caught high numbers of outdoor flying mosquitoes. Model simulations predict that, assuming area-wide coverage, the addition of such a push-pull system to existing prevention efforts will result in up to 20-fold reductions in the entomological inoculation rate. Reductions of such magnitude are also predicted when mosquitoes exhibit a high resistance against insecticides. We conclude that a push-pull system based on non-toxic volatiles provides an important addition to existing strategies for malaria prevention. |
| first_indexed | 2024-12-17T10:20:59Z |
| format | Article |
| id | doaj.art-af7a75d0789645dea5ac5507baa191ac |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T10:20:59Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-af7a75d0789645dea5ac5507baa191ac2022-12-21T21:52:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012341510.1371/journal.pone.0123415Field evaluation of a push-pull system to reduce malaria transmission.David J MengerPhilemon OmusulaMaarten HoldingaTobias HomanAna S CarreiraPatrice VandendaeleJean-Luc DeryckeCollins K MweresaWolfgang Richard MukabanaJoop J A van LoonWillem TakkenMalaria continues to place a disease burden on millions of people throughout the tropics, especially in sub-Saharan Africa. Although efforts to control mosquito populations and reduce human-vector contact, such as long-lasting insecticidal nets and indoor residual spraying, have led to significant decreases in malaria incidence, further progress is now threatened by the widespread development of physiological and behavioural insecticide-resistance as well as changes in the composition of vector populations. A mosquito-directed push-pull system based on the simultaneous use of attractive and repellent volatiles offers a complementary tool to existing vector-control methods. In this study, the combination of a trap baited with a five-compound attractant and a strip of net-fabric impregnated with micro-encapsulated repellent and placed in the eaves of houses, was tested in a malaria-endemic village in western Kenya. Using the repellent delta-undecalactone, mosquito house entry was reduced by more than 50%, while the traps caught high numbers of outdoor flying mosquitoes. Model simulations predict that, assuming area-wide coverage, the addition of such a push-pull system to existing prevention efforts will result in up to 20-fold reductions in the entomological inoculation rate. Reductions of such magnitude are also predicted when mosquitoes exhibit a high resistance against insecticides. We conclude that a push-pull system based on non-toxic volatiles provides an important addition to existing strategies for malaria prevention.https://doi.org/10.1371/journal.pone.0123415 |
| spellingShingle | David J Menger Philemon Omusula Maarten Holdinga Tobias Homan Ana S Carreira Patrice Vandendaele Jean-Luc Derycke Collins K Mweresa Wolfgang Richard Mukabana Joop J A van Loon Willem Takken Field evaluation of a push-pull system to reduce malaria transmission. PLoS ONE |
| title | Field evaluation of a push-pull system to reduce malaria transmission. |
| title_full | Field evaluation of a push-pull system to reduce malaria transmission. |
| title_fullStr | Field evaluation of a push-pull system to reduce malaria transmission. |
| title_full_unstemmed | Field evaluation of a push-pull system to reduce malaria transmission. |
| title_short | Field evaluation of a push-pull system to reduce malaria transmission. |
| title_sort | field evaluation of a push pull system to reduce malaria transmission |
| url | https://doi.org/10.1371/journal.pone.0123415 |
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