Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia
Combining cytarabine and mitoxantrone with the tricarboxylic acid cycle inhibitor devimistat has been reported in a phase I clinical trial with relapsed or refractory acute myeloid leukaemia (AML). Here, the authors report the outcomes of a phase II study, analyse samples from both phases and perfor...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29039-4 |
| _version_ | 1811273011223855104 |
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| author | Rebecca Anderson Lance D. Miller Scott Isom Jeff W. Chou Kristin M. Pladna Nathaniel J. Schramm Leslie R. Ellis Dianna S. Howard Rupali R. Bhave Megan Manuel Sarah Dralle Susan Lyerly Bayard L. Powell Timothy S. Pardee |
| author_facet | Rebecca Anderson Lance D. Miller Scott Isom Jeff W. Chou Kristin M. Pladna Nathaniel J. Schramm Leslie R. Ellis Dianna S. Howard Rupali R. Bhave Megan Manuel Sarah Dralle Susan Lyerly Bayard L. Powell Timothy S. Pardee |
| author_sort | Rebecca Anderson |
| collection | DOAJ |
| description | Combining cytarabine and mitoxantrone with the tricarboxylic acid cycle inhibitor devimistat has been reported in a phase I clinical trial with relapsed or refractory acute myeloid leukaemia (AML). Here, the authors report the outcomes of a phase II study, analyse samples from both phases and perform preclinical analyses that show mitochondrial fission or autophagy inhibition sensitizes AML cells to devimistat. |
| first_indexed | 2024-04-12T22:51:30Z |
| format | Article |
| id | doaj.art-af7e039587ff405b8de70ccdba887ce2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T22:51:30Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-af7e039587ff405b8de70ccdba887ce22022-12-22T03:13:20ZengNature PortfolioNature Communications2041-17232022-03-0113111310.1038/s41467-022-29039-4Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemiaRebecca Anderson0Lance D. Miller1Scott Isom2Jeff W. Chou3Kristin M. Pladna4Nathaniel J. Schramm5Leslie R. Ellis6Dianna S. Howard7Rupali R. Bhave8Megan Manuel9Sarah Dralle10Susan Lyerly11Bayard L. Powell12Timothy S. Pardee13Section on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistDepartment of Cancer Biology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistDepartment of Biostatistics and Data Science, Wake Forest Public Health SciencesDepartment of Biostatistics and Data Science, Wake Forest Public Health SciencesSection on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistSection on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistSection on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistSection on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistSection on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistSection on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistSection on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistSection on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistSection on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistSection on Hematology and Oncology, Comprehensive Cancer Center of Atrium Health Wake Forest BaptistCombining cytarabine and mitoxantrone with the tricarboxylic acid cycle inhibitor devimistat has been reported in a phase I clinical trial with relapsed or refractory acute myeloid leukaemia (AML). Here, the authors report the outcomes of a phase II study, analyse samples from both phases and perform preclinical analyses that show mitochondrial fission or autophagy inhibition sensitizes AML cells to devimistat.https://doi.org/10.1038/s41467-022-29039-4 |
| spellingShingle | Rebecca Anderson Lance D. Miller Scott Isom Jeff W. Chou Kristin M. Pladna Nathaniel J. Schramm Leslie R. Ellis Dianna S. Howard Rupali R. Bhave Megan Manuel Sarah Dralle Susan Lyerly Bayard L. Powell Timothy S. Pardee Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia Nature Communications |
| title | Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia |
| title_full | Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia |
| title_fullStr | Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia |
| title_full_unstemmed | Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia |
| title_short | Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia |
| title_sort | phase ii trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia |
| url | https://doi.org/10.1038/s41467-022-29039-4 |
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