Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma
Trace amine-associated receptors (TAARs) interact with amine compounds called “trace amines” which are present in tissues at low concentrations. Recently, TAARs expression in neoplastic tumors was reported. In this study, TAARs expression was analyzed in public RNAseq datasets in nevi and melanoma s...
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MDPI AG
2022-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/1/114 |
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| author | Anastasia N. Vaganova Savelii R. Kuvarzin Anastasia M. Sycheva Raul R. Gainetdinov |
| author_facet | Anastasia N. Vaganova Savelii R. Kuvarzin Anastasia M. Sycheva Raul R. Gainetdinov |
| author_sort | Anastasia N. Vaganova |
| collection | DOAJ |
| description | Trace amine-associated receptors (TAARs) interact with amine compounds called “trace amines” which are present in tissues at low concentrations. Recently, TAARs expression in neoplastic tumors was reported. In this study, TAARs expression was analyzed in public RNAseq datasets in nevi and melanoma samples and compared to the expression of dopamine receptors (DRDs) that are known to be involved in melanoma pathogenesis. It was found that all DRDs and TAARs are expressed in nevi at comparable levels. Differential expression analysis demonstrated the drastic decrease of TAAR1, TAAR2, TAAR5, TAAR6, and TAAR8 expression in melanomas compared to benign nevi with only TAAR6, TAAR8, and TAAR9 remaining detectable in malignant tumors. No association of TAARs expression levels and melanoma clinicopathological characteristics was observed. TAARs co-expressed genes in melanoma and nevi were selected by correlation values for comparative pathway enrichment analysis between malignant and benign neoplasia. It was found that coexpression of TAARs with genes inquired in neurotransmitter signaling is lost in melanoma, and tumor-specific association of TAAR6 expression with the mTOR pathway and inflammatory signaling is observed. It is not excluded that TAARs may have certain functions in melanoma pathogenesis, the significance of which to tumor progression is yet to be understood. |
| first_indexed | 2024-03-10T01:50:18Z |
| format | Article |
| id | doaj.art-af7fdb856539431b83fb6f9cce6d5a1f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T01:50:18Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-af7fdb856539431b83fb6f9cce6d5a1f2023-11-23T13:07:16ZengMDPI AGBiomolecules2218-273X2022-01-0112111410.3390/biom12010114Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in MelanomaAnastasia N. Vaganova0Savelii R. Kuvarzin1Anastasia M. Sycheva2Raul R. Gainetdinov3Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7/9, 199034 St. Petersburg, RussiaInstitute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7/9, 199034 St. Petersburg, RussiaDepartment of Pathology of Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, Build. 30, L’va Tolstogo Str. 6–8, 197022 Saint Petersburg, RussiaInstitute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7/9, 199034 St. Petersburg, RussiaTrace amine-associated receptors (TAARs) interact with amine compounds called “trace amines” which are present in tissues at low concentrations. Recently, TAARs expression in neoplastic tumors was reported. In this study, TAARs expression was analyzed in public RNAseq datasets in nevi and melanoma samples and compared to the expression of dopamine receptors (DRDs) that are known to be involved in melanoma pathogenesis. It was found that all DRDs and TAARs are expressed in nevi at comparable levels. Differential expression analysis demonstrated the drastic decrease of TAAR1, TAAR2, TAAR5, TAAR6, and TAAR8 expression in melanomas compared to benign nevi with only TAAR6, TAAR8, and TAAR9 remaining detectable in malignant tumors. No association of TAARs expression levels and melanoma clinicopathological characteristics was observed. TAARs co-expressed genes in melanoma and nevi were selected by correlation values for comparative pathway enrichment analysis between malignant and benign neoplasia. It was found that coexpression of TAARs with genes inquired in neurotransmitter signaling is lost in melanoma, and tumor-specific association of TAAR6 expression with the mTOR pathway and inflammatory signaling is observed. It is not excluded that TAARs may have certain functions in melanoma pathogenesis, the significance of which to tumor progression is yet to be understood.https://www.mdpi.com/2218-273X/12/1/114TAAR1TAAR2TAAR5TAAR6TAAR8TAAR9 |
| spellingShingle | Anastasia N. Vaganova Savelii R. Kuvarzin Anastasia M. Sycheva Raul R. Gainetdinov Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma Biomolecules TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAAR9 |
| title | Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma |
| title_full | Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma |
| title_fullStr | Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma |
| title_full_unstemmed | Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma |
| title_short | Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma |
| title_sort | deregulation of trace amine associated receptors taar expression and signaling mode in melanoma |
| topic | TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAAR9 |
| url | https://www.mdpi.com/2218-273X/12/1/114 |
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