SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells

SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells

The Fanconi anemia (FA) pathway safeguards genomic stability through cell cycle regulation and DNA damage repair. The canonical tumor suppressive role of FA proteins in the repair of DNA damage during interphase is well established, but their function in mitosis is incompletely understood. Here, we...

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Bibliographic Details
Main Authors: Ka‐Kui Chan, Zahi Abdul‐Sater, Aditya Sheth, Dana K. Mitchell, Richa Sharma, Donna M. Edwards, Ying He, Grzegorz Nalepa, Steven D. Rhodes, D. Wade Clapp, Elizabeth A. Sierra Potchanant
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Molecular Oncology
Subjects:
cancer
Fanconi anemia pathway
SIK2
spindle assembly checkpoint
synthetic lethality
Online Access:https://doi.org/10.1002/1878-0261.13027

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