Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes
Jun Feng, Liya Zhang, Jihong Tang, Bingbing Zhang, Xiao Xiao, Xiaoyan Shi Department of Neurology, Children’s Hospital of Soochow University, Suzhou, Jiangsu, 215025, People’s Republic of ChinaCorrespondence: Liya Zhang; Jihong Tang, Email zhliyasz@163.com; tjhsuzhou@163.comObjective: To evaluate th...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-03-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/clinical-analysis-of-lacosamide-monotherapy-in-the-treatment-of-self-l-peer-reviewed-fulltext-article-NDT |
| _version_ | 1797275635564937216 |
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| author | Feng J Zhang L Tang J Zhang B Xiao X Shi X |
| author_facet | Feng J Zhang L Tang J Zhang B Xiao X Shi X |
| author_sort | Feng J |
| collection | DOAJ |
| description | Jun Feng, Liya Zhang, Jihong Tang, Bingbing Zhang, Xiao Xiao, Xiaoyan Shi Department of Neurology, Children’s Hospital of Soochow University, Suzhou, Jiangsu, 215025, People’s Republic of ChinaCorrespondence: Liya Zhang; Jihong Tang, Email zhliyasz@163.com; tjhsuzhou@163.comObjective: To evaluate the efficacy and safety of lacosamide (LCM) monotherapy in the treatment of self-limited epilepsy with centrotemporal spikes (SeLECTS).Methods: In this study, 89 children with SeLECTS who were treated with LCM monotherapy in the Children’s Hospital Affiliated to Soochow University from June 2019 to June 2021 were included. Clinical seizures and spike wave index (SWI) on video EEG during slow-wave sleep were evaluated before and after treatment. The role of LCM monotherapy in improving SWI, controlling clinical seizures and improving cognition was analyzed, and corresponding adverse reactions were documented.Results: There were 52 males and 37 females in this group, with an average age of 7.6 ± 2.1 years. The total effective rate was 93.83% and at 18 months of treatment, the cumulative control rate was 85.19%, the retention rate was 91.01% and the effective rate in terms of EEG spike index was 72.92%, all of which showed a high rate; there was no statistically significant difference in intelligence quotient before and after treatment (P > 0.05). In addition, it was found in the study that the earlier the age of onset, the less obvious the improvement in SWI after LCM treatment; the lower the baseline seizure frequency, the more significant the improvement in SWI after LCM treatment.Conclusion: LCM monotherapy had curative effect and adverse reactions for SeLECTS, with no negative impact on cognition. These significant findings indicate that LCM is likely to become a widely prescribed ASM for the treatment of SeLECTS. Meanwhile, the onset age and baseline seizure frequency had certain value in judging prognosis and predicting curative effect.Keywords: lacosamide, epilepsy, self-limited epilepsy with centrotemporal spikes, efficacy, safety |
| first_indexed | 2024-03-07T15:17:17Z |
| format | Article |
| id | doaj.art-af81da1745c74d7abe654ef7e08860c4 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-03-07T15:17:17Z |
| publishDate | 2024-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-af81da1745c74d7abe654ef7e08860c42024-03-05T17:51:53ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212024-03-01Volume 2045946790906Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal SpikesFeng JZhang LTang JZhang BXiao XShi XJun Feng, Liya Zhang, Jihong Tang, Bingbing Zhang, Xiao Xiao, Xiaoyan Shi Department of Neurology, Children’s Hospital of Soochow University, Suzhou, Jiangsu, 215025, People’s Republic of ChinaCorrespondence: Liya Zhang; Jihong Tang, Email zhliyasz@163.com; tjhsuzhou@163.comObjective: To evaluate the efficacy and safety of lacosamide (LCM) monotherapy in the treatment of self-limited epilepsy with centrotemporal spikes (SeLECTS).Methods: In this study, 89 children with SeLECTS who were treated with LCM monotherapy in the Children’s Hospital Affiliated to Soochow University from June 2019 to June 2021 were included. Clinical seizures and spike wave index (SWI) on video EEG during slow-wave sleep were evaluated before and after treatment. The role of LCM monotherapy in improving SWI, controlling clinical seizures and improving cognition was analyzed, and corresponding adverse reactions were documented.Results: There were 52 males and 37 females in this group, with an average age of 7.6 ± 2.1 years. The total effective rate was 93.83% and at 18 months of treatment, the cumulative control rate was 85.19%, the retention rate was 91.01% and the effective rate in terms of EEG spike index was 72.92%, all of which showed a high rate; there was no statistically significant difference in intelligence quotient before and after treatment (P > 0.05). In addition, it was found in the study that the earlier the age of onset, the less obvious the improvement in SWI after LCM treatment; the lower the baseline seizure frequency, the more significant the improvement in SWI after LCM treatment.Conclusion: LCM monotherapy had curative effect and adverse reactions for SeLECTS, with no negative impact on cognition. These significant findings indicate that LCM is likely to become a widely prescribed ASM for the treatment of SeLECTS. Meanwhile, the onset age and baseline seizure frequency had certain value in judging prognosis and predicting curative effect.Keywords: lacosamide, epilepsy, self-limited epilepsy with centrotemporal spikes, efficacy, safetyhttps://www.dovepress.com/clinical-analysis-of-lacosamide-monotherapy-in-the-treatment-of-self-l-peer-reviewed-fulltext-article-NDTlacosamideepilepsyself-limited epilepsy with centrotemporal spikesefficacysafety |
| spellingShingle | Feng J Zhang L Tang J Zhang B Xiao X Shi X Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes Neuropsychiatric Disease and Treatment lacosamide epilepsy self-limited epilepsy with centrotemporal spikes efficacy safety |
| title | Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes |
| title_full | Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes |
| title_fullStr | Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes |
| title_full_unstemmed | Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes |
| title_short | Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes |
| title_sort | clinical analysis of lacosamide monotherapy in the treatment of self limited epilepsy with centrotemporal spikes |
| topic | lacosamide epilepsy self-limited epilepsy with centrotemporal spikes efficacy safety |
| url | https://www.dovepress.com/clinical-analysis-of-lacosamide-monotherapy-in-the-treatment-of-self-l-peer-reviewed-fulltext-article-NDT |
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