Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study
BackgroundSeveral recent studies speculated that the gut microbiota is associated with sensorineural hearing loss (SNHL) and proposed the concept of the gut–inner ear axis. However, the causal effect of gut microbiota on SNHL is still unknown. In this study, we performed a two-sample Mendelian rando...
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1230125/full |
| _version_ | 1827792667644264448 |
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| author | Qiuyuan Yin Guolin Shi Lei Zhu |
| author_facet | Qiuyuan Yin Guolin Shi Lei Zhu |
| author_sort | Qiuyuan Yin |
| collection | DOAJ |
| description | BackgroundSeveral recent studies speculated that the gut microbiota is associated with sensorineural hearing loss (SNHL) and proposed the concept of the gut–inner ear axis. However, the causal effect of gut microbiota on SNHL is still unknown. In this study, we performed a two-sample Mendelian randomization (MR) analysis to estimate the causal effect of gut microbiota on SNHL.MethodsGut microbiota data were obtained from the largest available genome-wide association study (n = 18,340) conducted by the MiBioGen consortium. The summary statistics of SNHL were obtained from the FinnGen consortium R8 release data (28,310 cases and 302,750 controls). The causal effects were estimated with inverse-variance weighted, MR-Egger, and weighted median. Reverse Mendelian randomization analysis was performed on the bacteria that were found to be associated with SNHL in forward Mendelian randomization analysis. We then performed sensitivity analyses, including Cochran's Q-test, MR-Egger intercept test, MR-PRESSO, cML-MA-BIC, and leave-one-out analysis, to detect heterogeneity and pleiotropy.ResultsThe inverse-variance weighted results suggested that Lachnospiraceae (UCG001) had a significant protective effect against SNHL (odds ratio = 0.85, 95% confidence interval: 0.78–0.93, P = 6.99 × 10−4). In addition, Intestinimonas (odds ratio = 0.89, 95% confidence interval: 0.82–0.97, P = 8.53 × 10−3) presented a suggestively protective effect on SNHL. Rikenellaceae (RC9gutgroup) (odds ratio = 1.08, 95% confidence interval: 1.02–1.15, P = 0.01) and Eubacterium (hallii group) (odds ratio = 1.12, 95% confidence interval: 1.00–1.24, P = 0.048) suggestively increase the risk of SNHL. The results of the reverse MR analysis showed that there is no significant causal effect of SNHL on the gut microbiota. No significant heterogeneity of instrumental variables or pleiotropy was detected.ConclusionThe evidence that the four genera mentioned above are associated with SNHL supports the hypothesis of a gut–inner ear axis. Our study provides microbial markers for the prevention and treatment of SNHL, and further studies are needed to explore the mechanisms of the gut microbiome–inner ear axis in health and diseases. |
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| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-11T18:06:26Z |
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| spelling | doaj.art-af82101de10745a0b0fdca2ff1eb97922023-10-17T07:30:49ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-10-011410.3389/fmicb.2023.12301251230125Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization studyQiuyuan Yin0Guolin Shi1Lei Zhu2State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming, Yunnan, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming, Yunnan, ChinaBackgroundSeveral recent studies speculated that the gut microbiota is associated with sensorineural hearing loss (SNHL) and proposed the concept of the gut–inner ear axis. However, the causal effect of gut microbiota on SNHL is still unknown. In this study, we performed a two-sample Mendelian randomization (MR) analysis to estimate the causal effect of gut microbiota on SNHL.MethodsGut microbiota data were obtained from the largest available genome-wide association study (n = 18,340) conducted by the MiBioGen consortium. The summary statistics of SNHL were obtained from the FinnGen consortium R8 release data (28,310 cases and 302,750 controls). The causal effects were estimated with inverse-variance weighted, MR-Egger, and weighted median. Reverse Mendelian randomization analysis was performed on the bacteria that were found to be associated with SNHL in forward Mendelian randomization analysis. We then performed sensitivity analyses, including Cochran's Q-test, MR-Egger intercept test, MR-PRESSO, cML-MA-BIC, and leave-one-out analysis, to detect heterogeneity and pleiotropy.ResultsThe inverse-variance weighted results suggested that Lachnospiraceae (UCG001) had a significant protective effect against SNHL (odds ratio = 0.85, 95% confidence interval: 0.78–0.93, P = 6.99 × 10−4). In addition, Intestinimonas (odds ratio = 0.89, 95% confidence interval: 0.82–0.97, P = 8.53 × 10−3) presented a suggestively protective effect on SNHL. Rikenellaceae (RC9gutgroup) (odds ratio = 1.08, 95% confidence interval: 1.02–1.15, P = 0.01) and Eubacterium (hallii group) (odds ratio = 1.12, 95% confidence interval: 1.00–1.24, P = 0.048) suggestively increase the risk of SNHL. The results of the reverse MR analysis showed that there is no significant causal effect of SNHL on the gut microbiota. No significant heterogeneity of instrumental variables or pleiotropy was detected.ConclusionThe evidence that the four genera mentioned above are associated with SNHL supports the hypothesis of a gut–inner ear axis. Our study provides microbial markers for the prevention and treatment of SNHL, and further studies are needed to explore the mechanisms of the gut microbiome–inner ear axis in health and diseases.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1230125/fullsensorineural hearing lossgut microbiotagut–inner ear axisMendelian randomization studycausal effect |
| spellingShingle | Qiuyuan Yin Guolin Shi Lei Zhu Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study Frontiers in Microbiology sensorineural hearing loss gut microbiota gut–inner ear axis Mendelian randomization study causal effect |
| title | Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study |
| title_full | Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study |
| title_fullStr | Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study |
| title_full_unstemmed | Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study |
| title_short | Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study |
| title_sort | association between gut microbiota and sensorineural hearing loss a mendelian randomization study |
| topic | sensorineural hearing loss gut microbiota gut–inner ear axis Mendelian randomization study causal effect |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1230125/full |
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