The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease
Excessive or insufficient maternal nutrition can influence fetal development and the susceptibility of offspring to adult disease. As eating a fructose-rich diet is becoming more common, the effects of maternal fructose intake on offspring health is of increasing relevance. The gut is required to pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/5/1031 |
| _version_ | 1797474181187633152 |
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| author | Chien-Ning Hsu Hong-Ren Yu Julie Y. H. Chan Kay L. H. Wu Wei-Chia Lee You-Lin Tain |
| author_facet | Chien-Ning Hsu Hong-Ren Yu Julie Y. H. Chan Kay L. H. Wu Wei-Chia Lee You-Lin Tain |
| author_sort | Chien-Ning Hsu |
| collection | DOAJ |
| description | Excessive or insufficient maternal nutrition can influence fetal development and the susceptibility of offspring to adult disease. As eating a fructose-rich diet is becoming more common, the effects of maternal fructose intake on offspring health is of increasing relevance. The gut is required to process fructose, and a high-fructose diet can alter the gut microbiome, resulting in gut dysbiosis and metabolic disorders. Current evidence from animal models has revealed that maternal fructose consumption causes various components of metabolic syndrome in adult offspring, while little is known about how gut microbiome is implicated in fructose-induced developmental programming and the consequential risks for developing chronic disease in offspring. This review will first summarize the current evidence supporting the link between fructose and developmental programming of adult diseases. This will be followed by presenting how gut microbiota links to common mechanisms underlying fructose-induced developmental programming. We also provide an overview of the reprogramming effects of gut microbiota-targeted therapy on fructose-induced developmental programming and how this approach may prevent adult-onset disease. Using gut microbiota-targeted therapy to prevent maternal fructose diet-induced developmental programming, we have the potential to mitigate the global burden of fructose-related disorders. |
| first_indexed | 2024-03-09T20:27:28Z |
| format | Article |
| id | doaj.art-af83695674a54a69a308c95f830e1595 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T20:27:28Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-af83695674a54a69a308c95f830e15952023-11-23T23:33:27ZengMDPI AGNutrients2072-66432022-02-01145103110.3390/nu14051031The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult DiseaseChien-Ning Hsu0Hong-Ren Yu1Julie Y. H. Chan2Kay L. H. Wu3Wei-Chia Lee4You-Lin Tain5Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanExcessive or insufficient maternal nutrition can influence fetal development and the susceptibility of offspring to adult disease. As eating a fructose-rich diet is becoming more common, the effects of maternal fructose intake on offspring health is of increasing relevance. The gut is required to process fructose, and a high-fructose diet can alter the gut microbiome, resulting in gut dysbiosis and metabolic disorders. Current evidence from animal models has revealed that maternal fructose consumption causes various components of metabolic syndrome in adult offspring, while little is known about how gut microbiome is implicated in fructose-induced developmental programming and the consequential risks for developing chronic disease in offspring. This review will first summarize the current evidence supporting the link between fructose and developmental programming of adult diseases. This will be followed by presenting how gut microbiota links to common mechanisms underlying fructose-induced developmental programming. We also provide an overview of the reprogramming effects of gut microbiota-targeted therapy on fructose-induced developmental programming and how this approach may prevent adult-onset disease. Using gut microbiota-targeted therapy to prevent maternal fructose diet-induced developmental programming, we have the potential to mitigate the global burden of fructose-related disorders.https://www.mdpi.com/2072-6643/14/5/1031fructosehypertensiongut microbiotadevelopmental origins of health and disease (DOHaD)short chain fatty acidprobiotics |
| spellingShingle | Chien-Ning Hsu Hong-Ren Yu Julie Y. H. Chan Kay L. H. Wu Wei-Chia Lee You-Lin Tain The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease Nutrients fructose hypertension gut microbiota developmental origins of health and disease (DOHaD) short chain fatty acid probiotics |
| title | The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease |
| title_full | The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease |
| title_fullStr | The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease |
| title_full_unstemmed | The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease |
| title_short | The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease |
| title_sort | impact of gut microbiome on maternal fructose intake induced developmental programming of adult disease |
| topic | fructose hypertension gut microbiota developmental origins of health and disease (DOHaD) short chain fatty acid probiotics |
| url | https://www.mdpi.com/2072-6643/14/5/1031 |
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