Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis
Xiaoyan Yang,1 Liyin Liao,1 Zizhen Liang,1 Shenglong Yu,2 Zhonghui Guo1 1Department of Laboratory Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, People’s Republic of China; 2Institute of Cardiovascular Medicine, The Affiliated Panyu Central Hospit...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-04-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/correlation-analysis-of-il-17-il-21-il-23-with-non-alcoholic-liver-fib-peer-reviewed-fulltext-article-JIR |
| _version_ | 1797201478105956352 |
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| author | Yang X Liao L Liang Z Yu S Guo Z |
| author_facet | Yang X Liao L Liang Z Yu S Guo Z |
| author_sort | Yang X |
| collection | DOAJ |
| description | Xiaoyan Yang,1 Liyin Liao,1 Zizhen Liang,1 Shenglong Yu,2 Zhonghui Guo1 1Department of Laboratory Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, People’s Republic of China; 2Institute of Cardiovascular Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, People’s Republic of ChinaCorrespondence: Zhonghui Guo, Department of Laboratory Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, No. 8, Fuyu East Road, Qiaonan Street, Panyu District, Guangzhou, 511400, People’s Republic of China, Tel +86 20 3485 8850, Email Guo_zhonghui23@163.comObjective: This research aimed to explore the involvement of interleukins (IL) - IL-6, IL-17, IL-21, and IL-23 - in the evolution and diagnosis of non-alcoholic liver fibrosis and cirrhosis.Methods: The study subjects were selected from the patients who visited the Department of Hepatology of X Hospital in Y City from August 2021 to April 2023. Peripheral blood samples were collected. All participants were divided into liver fibrosis, cirrhosis, hepatitis, and healthy subjects four groups. IL-21, IL-17, IL23, IL-6 were detected by double antibody sandwich.Results: The results showed that there was a significant difference in the levels of IL-17, IL-21, and IL-23 among the 4 groups (P< 0.0001). ROC curve analysis showed that the AUC values of IL-17, IL-21 and liver fiber 4 items were > 0.70, suggesting that the diagnostic efficacy of IL-17, IL-21 was similar to that of liver fiber 4 items. Spearman correlation analysis showed that IL-17 had a positive correlation with collagen type III N-peptide, type IV collagen, and Laminin (P < 0.05), and no correlation with Hyaluronic acid (P > 0.05).Conclusion: IL-17, IL-21, and IL-23 play a pivotal role in the inflammatory pathways associated with liver injuries, establishing themselves as potent auxiliary diagnostic markers in identifying liver fibrosis and cirrhosis.Keywords: non-alcoholic liver fibrosis, cirrhosis, diagnostic markers, cytokines |
| first_indexed | 2024-04-24T07:48:11Z |
| format | Article |
| id | doaj.art-af843de37c514c04b618b2fddab61a48 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-04-24T07:48:11Z |
| publishDate | 2024-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-af843de37c514c04b618b2fddab61a482024-04-18T18:02:44ZengDove Medical PressJournal of Inflammation Research1178-70312024-04-01Volume 172327233592020Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and CirrhosisYang XLiao LLiang ZYu SGuo ZXiaoyan Yang,1 Liyin Liao,1 Zizhen Liang,1 Shenglong Yu,2 Zhonghui Guo1 1Department of Laboratory Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, People’s Republic of China; 2Institute of Cardiovascular Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, People’s Republic of ChinaCorrespondence: Zhonghui Guo, Department of Laboratory Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, No. 8, Fuyu East Road, Qiaonan Street, Panyu District, Guangzhou, 511400, People’s Republic of China, Tel +86 20 3485 8850, Email Guo_zhonghui23@163.comObjective: This research aimed to explore the involvement of interleukins (IL) - IL-6, IL-17, IL-21, and IL-23 - in the evolution and diagnosis of non-alcoholic liver fibrosis and cirrhosis.Methods: The study subjects were selected from the patients who visited the Department of Hepatology of X Hospital in Y City from August 2021 to April 2023. Peripheral blood samples were collected. All participants were divided into liver fibrosis, cirrhosis, hepatitis, and healthy subjects four groups. IL-21, IL-17, IL23, IL-6 were detected by double antibody sandwich.Results: The results showed that there was a significant difference in the levels of IL-17, IL-21, and IL-23 among the 4 groups (P< 0.0001). ROC curve analysis showed that the AUC values of IL-17, IL-21 and liver fiber 4 items were > 0.70, suggesting that the diagnostic efficacy of IL-17, IL-21 was similar to that of liver fiber 4 items. Spearman correlation analysis showed that IL-17 had a positive correlation with collagen type III N-peptide, type IV collagen, and Laminin (P < 0.05), and no correlation with Hyaluronic acid (P > 0.05).Conclusion: IL-17, IL-21, and IL-23 play a pivotal role in the inflammatory pathways associated with liver injuries, establishing themselves as potent auxiliary diagnostic markers in identifying liver fibrosis and cirrhosis.Keywords: non-alcoholic liver fibrosis, cirrhosis, diagnostic markers, cytokineshttps://www.dovepress.com/correlation-analysis-of-il-17-il-21-il-23-with-non-alcoholic-liver-fib-peer-reviewed-fulltext-article-JIRnon-alcoholic liver fibrosiscirrhosisdiagnostic markerscytokines |
| spellingShingle | Yang X Liao L Liang Z Yu S Guo Z Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis Journal of Inflammation Research non-alcoholic liver fibrosis cirrhosis diagnostic markers cytokines |
| title | Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis |
| title_full | Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis |
| title_fullStr | Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis |
| title_full_unstemmed | Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis |
| title_short | Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis |
| title_sort | correlation analysis of il 17 il 21 il 23 with non alcoholic liver fibrosis and cirrhosis |
| topic | non-alcoholic liver fibrosis cirrhosis diagnostic markers cytokines |
| url | https://www.dovepress.com/correlation-analysis-of-il-17-il-21-il-23-with-non-alcoholic-liver-fib-peer-reviewed-fulltext-article-JIR |
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