Visceral leishmaniasis and haemophagocytic syndrome in an Omani child
The paper reports the case of a previously healthy 4-year-old-girl who presented with pallor, fever and hepatosplenomegaly. Laboratory findings included pancytopenia, hypertriglyceridemia and hyperferritinemia. Initial diagnosis of kala-azar could not be confirmed because of the absence of clinical...
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| Format: | Article |
| Language: | English |
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Sultan Qaboos University
2002-04-01
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| Series: | Sultan Qaboos University Medical Journal |
| Subjects: | |
| Online Access: | https://journals.squ.edu.om/index.php/squmj/article/view/1235 |
| _version_ | 1818472863236096000 |
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| author | Khalfan Al Sineidi Yasser A. Wali Zakia Al Lamki Anil V. Pathare |
| author_facet | Khalfan Al Sineidi Yasser A. Wali Zakia Al Lamki Anil V. Pathare |
| author_sort | Khalfan Al Sineidi |
| collection | DOAJ |
| description | The paper reports the case of a previously healthy 4-year-old-girl who presented with pallor, fever and hepatosplenomegaly. Laboratory findings included pancytopenia, hypertriglyceridemia and hyperferritinemia. Initial diagnosis of kala-azar could not be confirmed because of the absence of clinical evidence, negativity of bone marrow aspiration or specific serology for visceral leishmaniasis. Repeated marrow aspiration, performed due lack of clinical response, revealed histiocytes showing haemophagocytosis consistent with haemophagocytic lymphohistocytosis (HLH) and appropriate treatment was started. She continued to have high-grade fever, and a third bone marrow aspiration ultimately revealed presence of Leishmania amastigotes with evidence of active haemophagocytosis. The girl was treated with liposomal amphotericin (AmBisome) for 5 days, following which she recovered rapidly with definitive remission. |
| first_indexed | 2024-04-14T04:13:15Z |
| format | Article |
| id | doaj.art-af84cee1d23a465bbd593a5bf1b7135c |
| institution | Directory Open Access Journal |
| issn | 2075-051X 2075-0528 |
| language | English |
| last_indexed | 2024-04-14T04:13:15Z |
| publishDate | 2002-04-01 |
| publisher | Sultan Qaboos University |
| record_format | Article |
| series | Sultan Qaboos University Medical Journal |
| spelling | doaj.art-af84cee1d23a465bbd593a5bf1b7135c2022-12-22T02:13:03ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal2075-051X2075-05282002-04-014145481164Visceral leishmaniasis and haemophagocytic syndrome in an Omani childKhalfan Al Sineidi0Yasser A. Wali1Zakia Al Lamki2Anil V. Pathare3Department of Child Health (Haematology/Oncology Unit), College of Medicine & Health Sciences, Sultan Qaboos University, P.O.Box: 35, Al Khod-123, Sultanate of Oman.Department of Child Health (Haematology/Oncology Unit), College of Medicine & Health Sciences, Sultan Qaboos University, P.O.Box: 35, Al Khod-123, Sultanate of Oman.Department of Child Health (Haematology/Oncology Unit), College of Medicine & Health Sciences, Sultan Qaboos University, P.O.Box: 35, Al Khod-123, Sultanate of Oman.Haematology, Sultan Qaboos University Hospital, P.O.Box: 38, Al Khod-123, Sultanate of OmanThe paper reports the case of a previously healthy 4-year-old-girl who presented with pallor, fever and hepatosplenomegaly. Laboratory findings included pancytopenia, hypertriglyceridemia and hyperferritinemia. Initial diagnosis of kala-azar could not be confirmed because of the absence of clinical evidence, negativity of bone marrow aspiration or specific serology for visceral leishmaniasis. Repeated marrow aspiration, performed due lack of clinical response, revealed histiocytes showing haemophagocytosis consistent with haemophagocytic lymphohistocytosis (HLH) and appropriate treatment was started. She continued to have high-grade fever, and a third bone marrow aspiration ultimately revealed presence of Leishmania amastigotes with evidence of active haemophagocytosis. The girl was treated with liposomal amphotericin (AmBisome) for 5 days, following which she recovered rapidly with definitive remission.https://journals.squ.edu.om/index.php/squmj/article/view/1235haemophagocytic syndrome, visceral leishmaniasis, oman. |
| spellingShingle | Khalfan Al Sineidi Yasser A. Wali Zakia Al Lamki Anil V. Pathare Visceral leishmaniasis and haemophagocytic syndrome in an Omani child Sultan Qaboos University Medical Journal haemophagocytic syndrome, visceral leishmaniasis, oman. |
| title | Visceral leishmaniasis and haemophagocytic syndrome in an Omani child |
| title_full | Visceral leishmaniasis and haemophagocytic syndrome in an Omani child |
| title_fullStr | Visceral leishmaniasis and haemophagocytic syndrome in an Omani child |
| title_full_unstemmed | Visceral leishmaniasis and haemophagocytic syndrome in an Omani child |
| title_short | Visceral leishmaniasis and haemophagocytic syndrome in an Omani child |
| title_sort | visceral leishmaniasis and haemophagocytic syndrome in an omani child |
| topic | haemophagocytic syndrome, visceral leishmaniasis, oman. |
| url | https://journals.squ.edu.om/index.php/squmj/article/view/1235 |
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